Pleiades Publishing
Russian Journal of General Chemistry
,  volume 91 ,  issue 9 ,  pages 1661-1666

Synthesis and Chromatographic Analysis of the Neuroprotective Agent Mafedine and Related Compounds

Publication type: Journal Article
Publication date: 2021-09-01
Pleiades Publishing
scimago Q4
wos Q4
SJR: 0.179
CiteScore: 1.4
Impact factor: 0.8
ISSN: 10703632, 16083350
General Chemistry
Abstract
A procedure for the synthesis of 2-anilino-6-hydroxy-3-phenylpyrimidin-4(3H)-one (mafedine) without using alkali metal ethoxides has been developed and optimized. Mafedine-related compounds that can be formed as possible impurities have been prepared, and conditions for joint determination of these impurities by HPLC with spectrophotometric detection have been found. The structure of the mafedine decomposition product in solution has been identified by HPLC-ESI/MS.
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Sipkina N. Yu. et al. Synthesis and Chromatographic Analysis of the Neuroprotective Agent Mafedine and Related Compounds // Russian Journal of General Chemistry. 2021. Vol. 91. No. 9. pp. 1661-1666.
GOST all authors (up to 50) Copy
Sipkina N. Yu., Yuskovets V. N., Chernov N. M., Starova G. L., Yakovlev I. P. Synthesis and Chromatographic Analysis of the Neuroprotective Agent Mafedine and Related Compounds // Russian Journal of General Chemistry. 2021. Vol. 91. No. 9. pp. 1661-1666.
RIS |
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RIS Copy
TY - JOUR
DO - 10.1134/s1070363221090085
UR - https://doi.org/10.1134/s1070363221090085
TI - Synthesis and Chromatographic Analysis of the Neuroprotective Agent Mafedine and Related Compounds
T2 - Russian Journal of General Chemistry
AU - Sipkina, N Yu
AU - Yuskovets, V N
AU - Chernov, N M
AU - Starova, G L
AU - Yakovlev, I P
PY - 2021
DA - 2021/09/01
PB - Pleiades Publishing
SP - 1661-1666
IS - 9
VL - 91
SN - 1070-3632
SN - 1608-3350
ER -
BibTex |
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BibTex (up to 50 authors) Copy
@article{2021_Sipkina,
author = {N Yu Sipkina and V N Yuskovets and N M Chernov and G L Starova and I P Yakovlev},
title = {Synthesis and Chromatographic Analysis of the Neuroprotective Agent Mafedine and Related Compounds},
journal = {Russian Journal of General Chemistry},
year = {2021},
volume = {91},
publisher = {Pleiades Publishing},
month = {sep},
url = {https://doi.org/10.1134/s1070363221090085},
number = {9},
pages = {1661--1666},
doi = {10.1134/s1070363221090085}
}
MLA
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Sipkina, N. Yu., et al. “Synthesis and Chromatographic Analysis of the Neuroprotective Agent Mafedine and Related Compounds.” Russian Journal of General Chemistry, vol. 91, no. 9, Sep. 2021, pp. 1661-1666. https://doi.org/10.1134/s1070363221090085.