Pleiades Publishing
Doklady Biochemistry and Biophysics
,  volume 473 ,  issue 1 ,  pages 148-150

Development of target delivery system based on actinomycin class drugs and recombinant alpha-fetoprotein

E D Nikolskaya 1
, 
O A Zhunina 1
, 
N G Yabbarov 1
, 
V. I. Shvets 2
, 
B I Krugliy 1
, 
E S. Severin 1
1
 
Russian Research Center for Molecular Diagnostics and Therapy, Moscow, Russia | 
2
 
Publication type: Journal Article
Publication date: 2017-03-01
Pleiades Publishing
scimago Q3
wos Q4
SJR: 0.223
CiteScore: 1.5
Impact factor: 0.7
ISSN: 16076729, 16083091
General Chemistry
Biochemistry
General Medicine
Biophysics
Abstract
A recombinant alpha-fetoprotein (rAFP) was obtained in the yeast P. pastoris system, and its functional activity was confirmed. A method for producing polymer particles loaded with dactinomycin was developed, and a conjugate of these nanoparticles with rAFP was synthesized. The efficiency of the obtained conjugate on the HeLa, SKOV3, and MG-63 tumor cells and the absence of toxicity on the normal cells was shown. Experiments in vivo demonstrated a significant increase in the antitumor efficacy of the conjugate at a lower general toxicity as compared to the commercially available dactinomycin.
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GOST Copy
Nikolskaya E. D. et al. Development of target delivery system based on actinomycin class drugs and recombinant alpha-fetoprotein // Doklady Biochemistry and Biophysics. 2017. Vol. 473. No. 1. pp. 148-150.
GOST all authors (up to 50) Copy
Nikolskaya E. D., Zhunina O. A., Yabbarov N. G., Shvets V. I., Krugliy B. I., Severin E. S. Development of target delivery system based on actinomycin class drugs and recombinant alpha-fetoprotein // Doklady Biochemistry and Biophysics. 2017. Vol. 473. No. 1. pp. 148-150.
RIS |
Cite this
RIS Copy
TY - JOUR
DO - 10.1134/s1607672917020156
UR - https://doi.org/10.1134/s1607672917020156
TI - Development of target delivery system based on actinomycin class drugs and recombinant alpha-fetoprotein
T2 - Doklady Biochemistry and Biophysics
AU - Nikolskaya, E D
AU - Zhunina, O A
AU - Yabbarov, N G
AU - Shvets, V. I.
AU - Krugliy, B I
AU - Severin, E S.
PY - 2017
DA - 2017/03/01
PB - Pleiades Publishing
SP - 148-150
IS - 1
VL - 473
PMID - 28510139
SN - 1607-6729
SN - 1608-3091
ER -
BibTex |
Cite this
BibTex (up to 50 authors) Copy
@article{2017_Nikolskaya,
author = {E D Nikolskaya and O A Zhunina and N G Yabbarov and V. I. Shvets and B I Krugliy and E S. Severin},
title = {Development of target delivery system based on actinomycin class drugs and recombinant alpha-fetoprotein},
journal = {Doklady Biochemistry and Biophysics},
year = {2017},
volume = {473},
publisher = {Pleiades Publishing},
month = {mar},
url = {https://doi.org/10.1134/s1607672917020156},
number = {1},
pages = {148--150},
doi = {10.1134/s1607672917020156}
}
MLA
Cite this
MLA Copy
Nikolskaya, E. D., et al. “Development of target delivery system based on actinomycin class drugs and recombinant alpha-fetoprotein.” Doklady Biochemistry and Biophysics, vol. 473, no. 1, Mar. 2017, pp. 148-150. https://doi.org/10.1134/s1607672917020156.