Doklady Biochemistry and Biophysics, volume 473, issue 1, pages 148-150

Development of target delivery system based on actinomycin class drugs and recombinant alpha-fetoprotein

Zhunina O A 1
Yabbarov N G 1
Shvets V. I. 2
Krugliy B I 1
Severin E S. 1
Publication typeJournal Article
Publication date2017-03-01
Quartile SCImago
Q3
Quartile WOS
Q4
Impact factor0.8
ISSN16076729, 16083091
General Chemistry
Biochemistry
General Medicine
Biophysics
Abstract
A recombinant alpha-fetoprotein (rAFP) was obtained in the yeast P. pastoris system, and its functional activity was confirmed. A method for producing polymer particles loaded with dactinomycin was developed, and a conjugate of these nanoparticles with rAFP was synthesized. The efficiency of the obtained conjugate on the HeLa, SKOV3, and MG-63 tumor cells and the absence of toxicity on the normal cells was shown. Experiments in vivo demonstrated a significant increase in the antitumor efficacy of the conjugate at a lower general toxicity as compared to the commercially available dactinomycin.

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Nikolskaya E. D. et al. Development of target delivery system based on actinomycin class drugs and recombinant alpha-fetoprotein // Doklady Biochemistry and Biophysics. 2017. Vol. 473. No. 1. pp. 148-150.
GOST all authors (up to 50) Copy
Nikolskaya E. D., Zhunina O. A., Yabbarov N. G., Shvets V. I., Krugliy B. I., Severin E. S. Development of target delivery system based on actinomycin class drugs and recombinant alpha-fetoprotein // Doklady Biochemistry and Biophysics. 2017. Vol. 473. No. 1. pp. 148-150.
RIS |
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RIS Copy
TY - JOUR
DO - 10.1134/s1607672917020156
UR - https://doi.org/10.1134%2Fs1607672917020156
TI - Development of target delivery system based on actinomycin class drugs and recombinant alpha-fetoprotein
T2 - Doklady Biochemistry and Biophysics
AU - Nikolskaya, E D
AU - Zhunina, O A
AU - Yabbarov, N G
AU - Shvets, V. I.
AU - Krugliy, B I
AU - Severin, E S.
PY - 2017
DA - 2017/03/01 00:00:00
PB - Pleiades Publishing
SP - 148-150
IS - 1
VL - 473
SN - 1607-6729
SN - 1608-3091
ER -
BibTex |
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BibTex Copy
@article{2017_Nikolskaya
author = {E D Nikolskaya and O A Zhunina and N G Yabbarov and V. I. Shvets and B I Krugliy and E S. Severin},
title = {Development of target delivery system based on actinomycin class drugs and recombinant alpha-fetoprotein},
journal = {Doklady Biochemistry and Biophysics},
year = {2017},
volume = {473},
publisher = {Pleiades Publishing},
month = {mar},
url = {https://doi.org/10.1134%2Fs1607672917020156},
number = {1},
pages = {148--150},
doi = {10.1134/s1607672917020156}
}
MLA
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MLA Copy
Nikolskaya, E. D., et al. “Development of target delivery system based on actinomycin class drugs and recombinant alpha-fetoprotein.” Doklady Biochemistry and Biophysics, vol. 473, no. 1, Mar. 2017, pp. 148-150. https://doi.org/10.1134%2Fs1607672917020156.
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