Development of target delivery system based on actinomycin class drugs and recombinant alpha-fetoprotein

Nikolskaya E.D., Zhunina O.A., Yabbarov N.G., Shvets V.I., Krugliy B.I., Severin E.S.
Тип документаJournal Article
Дата публикации2017-03-25
Название журналаDoklady Biochemistry and Biophysics
ИздательPleiades Publishing
Квартиль по SCImagoQ3
Квартиль по Web of ScienceQ4
Импакт-фактор 20210.83
ISSN16076729, 16083091
General Chemistry
Biochemistry
General Medicine
Biophysics
Краткое описание
A recombinant alpha-fetoprotein (rAFP) was obtained in the yeast P. pastoris system, and its functional activity was confirmed. A method for producing polymer particles loaded with dactinomycin was developed, and a conjugate of these nanoparticles with rAFP was synthesized. The efficiency of the obtained conjugate on the HeLa, SKOV3, and MG-63 tumor cells and the absence of toxicity on the normal cells was shown. Experiments in vivo demonstrated a significant increase in the antitumor efficacy of the conjugate at a lower general toxicity as compared to the commercially available dactinomycin.
Пристатейные ссылки: 7
Цитируется в публикациях: 5
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Recombinant alpha-fetoprotein C-terminal fragment: The new recombinant vector for targeted delivery
Posypanova G.A., Gorokhovets N.V., Makarov V.A., Savvateeva L.V., Kireeva N.N., Severin S.E., Severin E.S.
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1. Nikolskaya E. D. и др. Development of target delivery system based on actinomycin class drugs and recombinant alpha-fetoprotein // Doklady Biochemistry and Biophysics. 2017. Т. 473. № 1. С. 148–150.
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TY - JOUR

DO - 10.1134/s1607672917020156

UR - http://dx.doi.org/10.1134/s1607672917020156

TI - Development of target delivery system based on actinomycin class drugs and recombinant alpha-fetoprotein

T2 - Doklady Biochemistry and Biophysics

AU - Nikolskaya, E. D.

AU - Zhunina, O. A.

AU - Yabbarov, N. G.

AU - Shvets, V. I.

AU - Krugliy, B. I.

AU - Severin, E. S.

PY - 2017

DA - 2017/03

PB - Pleiades Publishing Ltd

SP - 148-150

IS - 1

VL - 473

SN - 1607-6729

SN - 1608-3091

ER -

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@article{Nikolskaya_2017,

doi = {10.1134/s1607672917020156},

url = {https://doi.org/10.1134%2Fs1607672917020156},

year = 2017,

month = {mar},

publisher = {Pleiades Publishing Ltd},

volume = {473},

number = {1},

pages = {148--150},

author = {E. D. Nikolskaya and O. A. Zhunina and N. G. Yabbarov and V. I. Shvets and B. I. Krugliy and E. S. Severin},

title = {Development of target delivery system based on actinomycin class drugs and recombinant alpha-fetoprotein},

journal = {Doklady Biochemistry and Biophysics}

}

MLA
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Nikolskaya, E. D., et al. “Development of Target Delivery System Based on Actinomycin Class Drugs and Recombinant Alpha-Fetoprotein.” Doklady Biochemistry and Biophysics, vol. 473, no. 1, Mar. 2017, pp. 148–50. Crossref, https://doi.org/10.1134/s1607672917020156.