Doklady Biochemistry and Biophysics, volume 473, issue 1, pages 148-150
Development of target delivery system based on actinomycin class drugs and recombinant alpha-fetoprotein
Publication type: Journal Article
Publication date: 2017-03-01
Journal:
Doklady Biochemistry and Biophysics
Quartile SCImago
Q3
Quartile WOS
Q4
Impact factor: 0.8
ISSN: 16076729, 16083091
General Chemistry
Biochemistry
General Medicine
Biophysics
Abstract
A recombinant alpha-fetoprotein (rAFP) was obtained in the yeast P. pastoris system, and its functional activity was confirmed. A method for producing polymer particles loaded with dactinomycin was developed, and a conjugate of these nanoparticles with rAFP was synthesized. The efficiency of the obtained conjugate on the HeLa, SKOV3, and MG-63 tumor cells and the absence of toxicity on the normal cells was shown. Experiments in vivo demonstrated a significant increase in the antitumor efficacy of the conjugate at a lower general toxicity as compared to the commercially available dactinomycin.
Citations by journals
1
2
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Fine Chemical Technologies
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Fine Chemical Technologies
2 publications, 33.33%
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Biotekhnologiya
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Biotekhnologiya, 1, 16.67%
Biotekhnologiya
1 publication, 16.67%
|
Applied Biochemistry and Microbiology
|
Applied Biochemistry and Microbiology
1 publication, 16.67%
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Russian Journal of Biotherapy
|
Russian Journal of Biotherapy
1 publication, 16.67%
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1
2
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Citations by publishers
1
2
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RTU MIREA
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RTU MIREA
2 publications, 33.33%
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State Research Institute for Genetics and Selection of Industrial Microorganisms
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State Research Institute for Genetics and Selection of Industrial Microorganisms, 1, 16.67%
State Research Institute for Genetics and Selection of Industrial Microorganisms
1 publication, 16.67%
|
Pleiades Publishing
|
Pleiades Publishing
1 publication, 16.67%
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Publishing House ABV Press
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Publishing House ABV Press
1 publication, 16.67%
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1
2
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- We do not take into account publications that without a DOI.
- Statistics recalculated only for publications connected to researchers, organizations and labs registered on the platform.
- Statistics recalculated weekly.
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Nikolskaya E. D. et al. Development of target delivery system based on actinomycin class drugs and recombinant alpha-fetoprotein // Doklady Biochemistry and Biophysics. 2017. Vol. 473. No. 1. pp. 148-150.
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Nikolskaya E. D., Zhunina O. A., Yabbarov N. G., Shvets V. I., Krugliy B. I., Severin E. S. Development of target delivery system based on actinomycin class drugs and recombinant alpha-fetoprotein // Doklady Biochemistry and Biophysics. 2017. Vol. 473. No. 1. pp. 148-150.
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TY - JOUR
DO - 10.1134/s1607672917020156
UR - https://doi.org/10.1134%2Fs1607672917020156
TI - Development of target delivery system based on actinomycin class drugs and recombinant alpha-fetoprotein
T2 - Doklady Biochemistry and Biophysics
AU - Nikolskaya, E D
AU - Zhunina, O A
AU - Yabbarov, N G
AU - Shvets, V. I.
AU - Krugliy, B I
AU - Severin, E S.
PY - 2017
DA - 2017/03/01 00:00:00
PB - Pleiades Publishing
SP - 148-150
IS - 1
VL - 473
SN - 1607-6729
SN - 1608-3091
ER -
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@article{2017_Nikolskaya
author = {E D Nikolskaya and O A Zhunina and N G Yabbarov and V. I. Shvets and B I Krugliy and E S. Severin},
title = {Development of target delivery system based on actinomycin class drugs and recombinant alpha-fetoprotein},
journal = {Doklady Biochemistry and Biophysics},
year = {2017},
volume = {473},
publisher = {Pleiades Publishing},
month = {mar},
url = {https://doi.org/10.1134%2Fs1607672917020156},
number = {1},
pages = {148--150},
doi = {10.1134/s1607672917020156}
}
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MLA
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Nikolskaya, E. D., et al. “Development of target delivery system based on actinomycin class drugs and recombinant alpha-fetoprotein.” Doklady Biochemistry and Biophysics, vol. 473, no. 1, Mar. 2017, pp. 148-150. https://doi.org/10.1134%2Fs1607672917020156.
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