The First Dipeptide Mimetic of Neurotrofin-3: Design and Pharmacological Properties
T. A. Gudasheva
1
,
N M Sazonova
1
,
A. V. Tarasiuk
1
,
I O Logvinov
1
,
T. A. Antipova
1
,
D M Nikiforov
1
,
P Yu Povarnina
1
,
S. B. Seredenin
1
Publication type: Journal Article
Publication date: 2022-08-29
scimago Q3
wos Q4
SJR: 0.223
CiteScore: 1.5
Impact factor: 0.7
ISSN: 16076729, 16083091
PubMed ID:
36038682
General Chemistry
Biochemistry
General Medicine
Biophysics
Abstract
The dimeric dipeptide mimetic hexamethylenediamide bis-(N-monosuccinyl-L-asparaginyl-L-asparagine) (GTS-301) was created on the basis of the structure of the exposed region of the neurotrophin-3 4th loop. The new compound, as well as the full-length neurotrophin, activated the TrkC and TrkB receptors. GTS-301 showed neuroprotective activity in experiments on HT-22 mouse hippocampal cells under conditions of oxidative stress and glutamate toxicity at concentrations of 10–12 and 10–8 M, respectively, and antidepressant-like activity in the forced swimming test on mice with 7-day intraperitoneal administration in doses of 10–40 mg/kg.
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Total citations:
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Citations from 2025:
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Gudasheva T. A. et al. The First Dipeptide Mimetic of Neurotrofin-3: Design and Pharmacological Properties // Doklady Biochemistry and Biophysics. 2022. Vol. 505. No. 1. pp. 160-165.
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Gudasheva T. A., Sazonova N. M., Tarasiuk A. V., Logvinov I. O., Antipova T. A., Nikiforov D. M., Povarnina P. Yu., Seredenin S. B. The First Dipeptide Mimetic of Neurotrofin-3: Design and Pharmacological Properties // Doklady Biochemistry and Biophysics. 2022. Vol. 505. No. 1. pp. 160-165.
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RIS
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TY - JOUR
DO - 10.1134/s1607672922040032
UR - https://doi.org/10.1134/s1607672922040032
TI - The First Dipeptide Mimetic of Neurotrofin-3: Design and Pharmacological Properties
T2 - Doklady Biochemistry and Biophysics
AU - Gudasheva, T. A.
AU - Sazonova, N M
AU - Tarasiuk, A. V.
AU - Logvinov, I O
AU - Antipova, T. A.
AU - Nikiforov, D M
AU - Povarnina, P Yu
AU - Seredenin, S. B.
PY - 2022
DA - 2022/08/29
PB - Pleiades Publishing
SP - 160-165
IS - 1
VL - 505
PMID - 36038682
SN - 1607-6729
SN - 1608-3091
ER -
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BibTex (up to 50 authors)
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@article{2022_Gudasheva,
author = {T. A. Gudasheva and N M Sazonova and A. V. Tarasiuk and I O Logvinov and T. A. Antipova and D M Nikiforov and P Yu Povarnina and S. B. Seredenin},
title = {The First Dipeptide Mimetic of Neurotrofin-3: Design and Pharmacological Properties},
journal = {Doklady Biochemistry and Biophysics},
year = {2022},
volume = {505},
publisher = {Pleiades Publishing},
month = {aug},
url = {https://doi.org/10.1134/s1607672922040032},
number = {1},
pages = {160--165},
doi = {10.1134/s1607672922040032}
}
Cite this
MLA
Copy
Gudasheva, T. A., et al. “The First Dipeptide Mimetic of Neurotrofin-3: Design and Pharmacological Properties.” Doklady Biochemistry and Biophysics, vol. 505, no. 1, Aug. 2022, pp. 160-165. https://doi.org/10.1134/s1607672922040032.
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