Federal Research Center for Innovator and Emerging Biomedical and Pharmaceutical Technologies

Molecular pharmacology laboratory

Molecular Biology Pharmacology Biochemistry

Head of Laboratory

Tatiana A Antipova

PhD in Biological/biomedical sciences

Publications

Citations

513

h-index

Authorization required.

Investigation of the molecular and cellular mechanisms of action of drugs

Western blot
Cell and tissue culture
Methods for assessing the viability and growth of cell and tissue cultures
Evaluation of the mechanism of action of new compounds (apoptotic effect, effect on the cell cycle, DNA damage)

Tatiana Antipova

Head of Laboratory

Cergej Nikolaev

Researcher

Research directions

Investigation of neuroprotective activity of new compounds - low molecular weight mimetics of neurotrophin tropomyosin kinase receptors

Evaluation of neuroprotective activity in vitro, study of activation of neurotrophin tropomyosin kinase receptors and intracellular signaling pathways

Publications and patents

Mimetics of brain-derived neurotrophic factor loops 1 and 4 are active in a model of ischemic stroke in rats

Drug Design, Development and Therapy (Q1), 2016, Citations: 50

Dimeric dipeptide mimetics of the nerve growth factor Loop 4 and Loop 1 activate TRKA with different patterns of intracellular signal transduction

Journal of Biomedical Science (Q1), 2015, Citations: 47

Evidence of Selective Interaction of Nerve Growth Factor Dipeptide Mimetic GK-2 with TrkA Receptor Using TrkA and TrkB Knockout HT-22 Cells

Pharmaceutical Chemistry Journal (Q4), 2023, Citations: 3

Neuroprotective Effect of the Neuropeptide Cycloprolylglycine Depends on AMPA- and TrkB-Receptor Activation

Doklady Biochemistry and Biophysics (Q3), 2022, Citations: 2

Chronic ethanol consumption by rats before mating affects the offspring working memory

Bulletin of Experimental Biology and Medicine (Q3), 2023, Citations: 0

Found

Исследование фармакологических свойств дипептидного миметика 4-й петли NGF крысы в сравнении с дипептидным миметиком 4-й петли NGF человека in vitro.

2024 — 2025

| Антипова Татьяна Алексеевна

Изучение вклада нейрогенеза и синаптогенеза в фармакологические эффекты нейротрофинов в условиях экспериментальной модели острого нарушения мозгового кровообращения с использованием оригинальных миметиков NGF и BDNF

2018 — 2020

| Гудашева Татьяна Александровна

Дивергенция основных функций нейротрофинов с помощью их низкомолекуляных миметиков

2014 — 2016

| Гудашева Татьяна Александровна

Lab address

Москва, Балтийская ул., 8

Authorization required.