Journal of Porphyrins and Phthalocyanines, volume 27, issue 01n04, pages 728-740
Potential agents for combined photodynamic and chemotherapy in oncology based on Pt(II) complexes and pyridine-containing natural chlorins
Grin Mikhail
1
,
Suvorov Nikita
1
,
Tikhonov Sergey
1
,
Popov Alexander
1
,
Shelyagina Anastasia
1
,
Kirin Nikita
1
,
Usachev Maxim
1
,
Bragina Natalia
1
,
Plotnikova Ekaterina
1, 2
,
Pankratov Andrey
1, 2
Publication type: Journal Article
Publication date: 2023-01-01
Quartile SCImago
Q3
Quartile WOS
Q4
Impact factor: 1.5
ISSN: 10884246, 10991409
General Chemistry
Abstract
Combined therapy is currently a popular method for increasing the efficiency of antitumor treatment. It involves the use of two different tumor treatment methods, namely, chemotherapy and PDT. Combining a cytotoxic agent and a photosensitizer in a single molecule results in a synergistic antitumor effect that overcomes the multiple drug resistance and reduces the therapeutic drug doses. In this work, pyridine-containing natural chlorins were obtained by introducing a pyridine group into 131-[Formula: see text]-(4-aminobutyl)amide of chlorin [Formula: see text] and its bacteriochlorin analogue, [Formula: see text]-propyloxime-[Formula: see text]-propoxybacteriopurinimide as well as [Formula: see text]-aminobacteriopurinimide methyl ester. Moreover, a terpyridine residue was introduced as an external chelating moiety into [Formula: see text]-hydroxypurpurinimide and [Formula: see text]-aminobacteriopurinimide, and platinum complexes of all the above photosensitizers were obtained. The interactions of the latter with DNA were simulated and the lead compound, the platinum complex of pyridine derivative 131-[Formula: see text]-(4-aminobutyl)amide chlorin [Formula: see text], which may become a potential agent for combined photodynamic and chemotherapy in oncology, was selected. The ability of the compounds obtained to manifest photodynamic and chemocytotoxic effects on tumor cells of various genesis was shown.
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Molecules
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Molecules
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Multidisciplinary Digital Publishing Institute (MDPI)
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Multidisciplinary Digital Publishing Institute (MDPI)
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Grin M. et al. Potential agents for combined photodynamic and chemotherapy in oncology based on Pt(II) complexes and pyridine-containing natural chlorins // Journal of Porphyrins and Phthalocyanines. 2023. Vol. 27. No. 01n04. pp. 728-740.
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Grin M., Ostroverkhov P., Suvorov N., Tikhonov S., Popov A., Shelyagina A., Kirin N., Nichugovskiy A., Usachev M., Bragina N., Plotnikova E., Pankratov A. Potential agents for combined photodynamic and chemotherapy in oncology based on Pt(II) complexes and pyridine-containing natural chlorins // Journal of Porphyrins and Phthalocyanines. 2023. Vol. 27. No. 01n04. pp. 728-740.
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TY - JOUR
DO - 10.1142/s1088424623500761
UR - https://doi.org/10.1142%2Fs1088424623500761
TI - Potential agents for combined photodynamic and chemotherapy in oncology based on Pt(II) complexes and pyridine-containing natural chlorins
T2 - Journal of Porphyrins and Phthalocyanines
AU - Grin, Mikhail
AU - Ostroverkhov, Petr
AU - Suvorov, Nikita
AU - Tikhonov, Sergey
AU - Popov, Alexander
AU - Shelyagina, Anastasia
AU - Kirin, Nikita
AU - Nichugovskiy, Artemiy
AU - Usachev, Maxim
AU - Bragina, Natalia
AU - Plotnikova, Ekaterina
AU - Pankratov, Andrey
PY - 2023
DA - 2023/01/01 00:00:00
PB - World Scientific
SP - 728-740
IS - 01n04
VL - 27
SN - 1088-4246
SN - 1099-1409
ER -
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@article{2023_Grin,
author = {Mikhail Grin and Petr Ostroverkhov and Nikita Suvorov and Sergey Tikhonov and Alexander Popov and Anastasia Shelyagina and Nikita Kirin and Artemiy Nichugovskiy and Maxim Usachev and Natalia Bragina and Ekaterina Plotnikova and Andrey Pankratov},
title = {Potential agents for combined photodynamic and chemotherapy in oncology based on Pt(II) complexes and pyridine-containing natural chlorins},
journal = {Journal of Porphyrins and Phthalocyanines},
year = {2023},
volume = {27},
publisher = {World Scientific},
month = {jan},
url = {https://doi.org/10.1142%2Fs1088424623500761},
number = {01n04},
pages = {728--740},
doi = {10.1142/s1088424623500761}
}
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MLA
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Grin, Mikhail, et al. “Potential agents for combined photodynamic and chemotherapy in oncology based on Pt(II) complexes and pyridine-containing natural chlorins.” Journal of Porphyrins and Phthalocyanines, vol. 27, no. 01n04, Jan. 2023, pp. 728-740. https://doi.org/10.1142%2Fs1088424623500761.