Educational and Scientific Laboratory of Chemistry and Technology of Biologically Active Compounds and Immunochemistry

The laboratory conducts research in the field of development, synthesis and study of a new class of therapeutic agents – antibody drug conjugates (ADC), which perform an important function – the delivery of a powerful cytotoxic agent to tumor cells with minimal damage to healthy tissues. The laboratory develops antibody-drug conjugates (ADCs) for targeted delivery of chemotherapy drugs in the treatment of oncological diseases. Linkers binding monoclonal antibodies to a chemical agent or natural chloride are being developed. The study of biological and chemical properties of new pharmaceutical substances in the laboratory.

  1. High performance liquid chromatography with mass spectrometry (HPLC-MS)
  2. IR spectroscopy
  3. Immunochemical studies
  4. Immunocytochemistry
  5. Column chromatography
  6. Mass spectrometry
  7. Thin-layer chromatography
  8. UV spectroscopy
  9. NMR spectroscopy
  10. Fluorescence Spectroscopy

Research directions

Development of antibody-drug conjugates for targeted delivery of chemotherapy drugs in the treatment of oncological diseases.

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- Conjugates of natural chlorines with monoclonal antibodies - Antibody-chemopreparation conjugates - Targeted delivery of developed pharmaceutical substances - Comprehensive study of the physico-chemical properties of the obtained compounds - Study of the biological properties of the obtained substances at the cellular and organismal levels

Publications and patents

Found 
Михаил Александрович Грин, Петр Васильевич Островерхов, Александр Александрович Попов, Никита Владимирович Суворов, Виктор Алексеевич Погорилый, Сергей Иванович Тихонов, Никита Сергеевич Кирин, Екатерина Александровна Плотникова, Ольга Алексеевна Безбородова
RU2822269C1, 2024
Ольга Борисовна Абрамова, Валентина Владимировна Дрожжина, Екатерина Александровна Козловцева, Татьяна Петровна Сивоволова, Петр Васильевич Островерхов, Михаил Александрович Грин, Никита Сергеевич Кирин, Сергей Анатольевич Иванов, Андрей Дмитриевич Каприн
RU2022111096A, 2022

Lab address

пр. Вернадского, 86, Москва
Authorization required.