Educational and Scientific Laboratory of Chemistry and Technology of Biologically Active Compounds and Immunochemistry
Publications
8
Citations
80
h-index
4
Authorization required.
The laboratory conducts research in the field of development, synthesis and study of a new class of therapeutic agents – antibody drug conjugates (ADC), which perform an important function – the delivery of a powerful cytotoxic agent to tumor cells with minimal damage to healthy tissues. The laboratory develops antibody-drug conjugates (ADCs) for targeted delivery of chemotherapy drugs in the treatment of oncological diseases. Linkers binding monoclonal antibodies to a chemical agent or natural chloride are being developed. The study of biological and chemical properties of new pharmaceutical substances in the laboratory.
- High performance liquid chromatography with mass spectrometry (HPLC-MS)
- IR spectroscopy
- Immunochemical studies
- Immunocytochemistry
- Column chromatography
- Mass spectrometry
- Thin-layer chromatography
- UV spectroscopy
- NMR spectroscopy
- Fluorescence Spectroscopy
Anastasiya Puhova
Research Engineer
Anna Lezhnina
Student
Anastasiya Doronicheva
Student
Elizaveta Sporihina
Student
Polina Solomatina
Student
Yaroslav Bryanskiy
Student
Anastasiya Krasikova
Student
Aleksandra Lelyukhova
Student
Ekaterina Bugaeva
Student
Research directions
Development of antibody-drug conjugates for targeted delivery of chemotherapy drugs in the treatment of oncological diseases.
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- Conjugates of natural chlorines with monoclonal antibodies
- Antibody-chemopreparation conjugates
- Targeted delivery of developed pharmaceutical substances
- Comprehensive study of the physico-chemical properties of the obtained compounds
- Study of the biological properties of the obtained substances at the cellular and organismal levels
Publications and patents
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Михаил Александрович Грин, Петр Васильевич Островерхов, Александр Александрович Попов, Никита Владимирович Суворов, Виктор Алексеевич Погорилый, Сергей Иванович Тихонов, Никита Сергеевич Кирин, Екатерина Александровна Плотникова, Ольга Алексеевна Безбородова
RU2822269C1,
2024
Ольга Борисовна Абрамова, Валентина Владимировна Дрожжина, Екатерина Александровна Козловцева, Татьяна Петровна Сивоволова, Петр Васильевич Островерхов, Михаил Александрович Грин, Никита Сергеевич Кирин, Сергей Анатольевич Иванов, Андрей Дмитриевич Каприн
RU2022111096A,
2022
2023
—
2025
| Островерхов Петр Васильевич
2021
—
2023
| Грин Михаил Александрович
Lab address
пр. Вернадского, 86, Москва
Authorization required.