Open Access

BioMed Research International, volume 2014, pages 1-20

Rodent Models of Depression: Neurotrophic and Neuroinflammatory Biomarkers

Stepanichev Mikhail ¹

Dygalo Nikolay N ^{2, 3}

Grigoryan Grigory ¹

Shishkina Galina T. ²

Gulyaeva Natalia ¹

Hide authors affiliations Show authors affiliations: 3 affiliations

Laboratory of Functional Biochemistry of Nervous System and Laboratory of Conditioned Reflex and Emotion, Institute of Higher Nervous Activity and Neurophysiology, RAS, 5a Butlerov Street, Moscow 117485, Russia |

Laboratory of Functional Neurogenomics, Institute of Cytology and Genetics, Russian Academy of Sciences, 10 Academician Lavrentyev Avenue, Novosibirsk 630090, Russia |

Department of Physiology, Novosibirsk State University, 2 Pirogov Street, Novosibirsk 630090, Russia |

Publication type: Journal Article

Publication date: 2014-11-10

Hindawi Limited

Journal: BioMed Research International

Quartile SCImago

Quartile WOS

—

Impact factor: —

ISSN: 23146133, 23146141

DOI: 10.1155/2014/932757

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General Biochemistry, Genetics and Molecular Biology

General Medicine

General Immunology and Microbiology

Abstract

Rodent models are an indispensable tool for studying etiology and progress of depression. Since interrelated systems of neurotrophic factors and cytokines comprise major regulatory mechanisms controlling normal brain plasticity, impairments of these systems form the basis for development of cerebral pathologies, including mental diseases. The present review focuses on the numerous experimental rodent models of depression induced by different stress factors (exteroceptive and interoceptive) during early life (including prenatal period) or adulthood, giving emphasis to the data on the changes of neurotrophic factors and neuroinflammatory indices in the brain. These parameters are closely related to behavioral depression-like symptoms and impairments of neuronal plasticity and are both gender- and genotype-dependent. Stress-related changes in expression of neurotrophins and cytokines in rodent brain are region-specific. Some contradictory data reported by different groups may be a consequence of differences of stress paradigms or their realization in different laboratories. Like all experimental models, stress-induced depression-like conditions are experimental simplification of clinical depression states; however, they are suitable for understanding the involvement of neurotrophic factors and cytokines in the pathogenesis of the disease—a goal unachievable in the clinical reality. These major regulatory systems may be important targets for therapeutic measures as well as for development of drugs for treatment of depression states.

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Citations by journals

	1 2 3 4 5 6 7
Neurochemical Journal	Neurochemical Journal, 7, 6.19% Neurochemical Journal 7 publications, 6.19%
Neuroscience and Behavioral Physiology	Neuroscience and Behavioral Physiology, 5, 4.42% Neuroscience and Behavioral Physiology 5 publications, 4.42%
Behavioural Brain Research	Behavioural Brain Research, 5, 4.42% Behavioural Brain Research 5 publications, 4.42%
Neuroscience	Neuroscience, 4, 3.54% Neuroscience 4 publications, 3.54%
Биохимия	Биохимия, 3, 2.65% Биохимия 3 publications, 2.65%
European Neuropsychopharmacology	European Neuropsychopharmacology, 3, 2.65% European Neuropsychopharmacology 3 publications, 2.65%
Biomedicine and Pharmacotherapy	Biomedicine and Pharmacotherapy, 3, 2.65% Biomedicine and Pharmacotherapy 3 publications, 2.65%
Biochemistry (Moscow)	Biochemistry (Moscow), 3, 2.65% Biochemistry (Moscow) 3 publications, 2.65%
Russian Journal of Genetics: Applied Research	Russian Journal of Genetics: Applied Research, 3, 2.65% Russian Journal of Genetics: Applied Research 3 publications, 2.65%
International Journal of Environmental Research and Public Health	International Journal of Environmental Research and Public Health, 2, 1.77% International Journal of Environmental Research and Public Health 2 publications, 1.77%
Frontiers in Neuroscience	Frontiers in Neuroscience, 2, 1.77% Frontiers in Neuroscience 2 publications, 1.77%
Neurochemical Research	Neurochemical Research, 2, 1.77% Neurochemical Research 2 publications, 1.77%
Psychopharmacology	Psychopharmacology, 2, 1.77% Psychopharmacology 2 publications, 1.77%
Neurotoxicity Research	Neurotoxicity Research, 2, 1.77% Neurotoxicity Research 2 publications, 1.77%
Neurochemistry International	Neurochemistry International, 2, 1.77% Neurochemistry International 2 publications, 1.77%
European Journal of Pharmacology	European Journal of Pharmacology, 2, 1.77% European Journal of Pharmacology 2 publications, 1.77%
Neuroscience Letters	Neuroscience Letters, 2, 1.77% Neuroscience Letters 2 publications, 1.77%
Progress in Neuro-Psychopharmacology and Biological Psychiatry	Progress in Neuro-Psychopharmacology and Biological Psychiatry, 2, 1.77% Progress in Neuro-Psychopharmacology and Biological Psychiatry 2 publications, 1.77%
Zhurnal Nevrologii i Psikhiatrii imeni S.S. Korsakova	Zhurnal Nevrologii i Psikhiatrii imeni S.S. Korsakova, 2, 1.77% Zhurnal Nevrologii i Psikhiatrii imeni S.S. Korsakova 2 publications, 1.77%
International Journal of Neuropsychopharmacology	International Journal of Neuropsychopharmacology, 2, 1.77% International Journal of Neuropsychopharmacology 2 publications, 1.77%
World Journal of Psychiatry	World Journal of Psychiatry, 1, 0.88% World Journal of Psychiatry 1 publication, 0.88%
Current Neuropharmacology	Current Neuropharmacology, 1, 0.88% Current Neuropharmacology 1 publication, 0.88%
NeuroImmunoModulation	NeuroImmunoModulation, 1, 0.88% NeuroImmunoModulation 1 publication, 0.88%
Neuroendocrinology	Neuroendocrinology, 1, 0.88% Neuroendocrinology 1 publication, 0.88%
European Neurology	European Neurology, 1, 0.88% European Neurology 1 publication, 0.88%
Journal of Child and Adolescent Psychopharmacology	Journal of Child and Adolescent Psychopharmacology, 1, 0.88% Journal of Child and Adolescent Psychopharmacology 1 publication, 0.88%
Medical Acupuncture	Medical Acupuncture, 1, 0.88% Medical Acupuncture 1 publication, 0.88%
Molecular Medicine Reports	Molecular Medicine Reports, 1, 0.88% Molecular Medicine Reports 1 publication, 0.88%
Molecules	Molecules, 1, 0.88% Molecules 1 publication, 0.88%

	1 2 3 4 5 6 7

Citations by publishers

	5 10 15 20 25 30 35
Elsevier	Elsevier, 35, 30.97% Elsevier 35 publications, 30.97%
Springer Nature	Springer Nature, 20, 17.7% Springer Nature 20 publications, 17.7%
Pleiades Publishing	Pleiades Publishing, 18, 15.93% Pleiades Publishing 18 publications, 15.93%
Frontiers Media S.A.	Frontiers Media S.A., 8, 7.08% Frontiers Media S.A. 8 publications, 7.08%
S. Karger AG	S. Karger AG, 3, 2.65% S. Karger AG 3 publications, 2.65%
Multidisciplinary Digital Publishing Institute (MDPI)	Multidisciplinary Digital Publishing Institute (MDPI), 3, 2.65% Multidisciplinary Digital Publishing Institute (MDPI) 3 publications, 2.65%
Wiley	Wiley, 3, 2.65% Wiley 3 publications, 2.65%
Oxford University Press	Oxford University Press, 3, 2.65% Oxford University Press 3 publications, 2.65%
Bentham Science	Bentham Science, 2, 1.77% Bentham Science 2 publications, 1.77%
Mary Ann Liebert	Mary Ann Liebert, 2, 1.77% Mary Ann Liebert 2 publications, 1.77%
Media Sphere Publishing Group	Media Sphere Publishing Group, 2, 1.77% Media Sphere Publishing Group 2 publications, 1.77%
Taylor & Francis	Taylor & Francis, 2, 1.77% Taylor & Francis 2 publications, 1.77%
Baishideng Publishing Group	Baishideng Publishing Group, 1, 0.88% Baishideng Publishing Group 1 publication, 0.88%
Spandidos Publications	Spandidos Publications, 1, 0.88% Spandidos Publications 1 publication, 0.88%
China Science Publishing & Media	China Science Publishing & Media, 1, 0.88% China Science Publishing & Media 1 publication, 0.88%
Walter de Gruyter	Walter de Gruyter, 1, 0.88% Walter de Gruyter 1 publication, 0.88%
Society for Neuroscience	Society for Neuroscience, 1, 0.88% Society for Neuroscience 1 publication, 0.88%
BMJ	BMJ, 1, 0.88% BMJ 1 publication, 0.88%
	5 10 15 20 25 30 35

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Stepanichev M. et al. Rodent Models of Depression: Neurotrophic and Neuroinflammatory Biomarkers // BioMed Research International. 2014. Vol. 2014. pp. 1-20.

GOST all authors (up to 50) Copy

Stepanichev M., Dygalo N. N., Grigoryan G., Shishkina G. T., Gulyaeva N. Rodent Models of Depression: Neurotrophic and Neuroinflammatory Biomarkers // BioMed Research International. 2014. Vol. 2014. pp. 1-20.

RIS |

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RIS Copy

TY - JOUR

DO - 10.1155/2014/932757

UR - https://doi.org/10.1155%2F2014%2F932757

TI - Rodent Models of Depression: Neurotrophic and Neuroinflammatory Biomarkers

T2 - BioMed Research International

AU - Stepanichev, Mikhail

AU - Dygalo, Nikolay N

AU - Grigoryan, Grigory

AU - Shishkina, Galina T.

AU - Gulyaeva, Natalia

PY - 2014

DA - 2014/11/10 00:00:00

PB - Hindawi Limited

SP - 1-20

VL - 2014

SN - 2314-6133

SN - 2314-6141

ER -

BibTex

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BibTex Copy

@article{2014_Stepanichev,

author = {Mikhail Stepanichev and Nikolay N Dygalo and Grigory Grigoryan and Galina T. Shishkina and Natalia Gulyaeva},

title = {Rodent Models of Depression: Neurotrophic and Neuroinflammatory Biomarkers},

journal = {BioMed Research International},

year = {2014},

volume = {2014},

publisher = {Hindawi Limited},

month = {nov},

url = {https://doi.org/10.1155%2F2014%2F932757},

pages = {1--20},

doi = {10.1155/2014/932757}

}

Found error?

Publisher

Hindawi Limited

Journal

BioMed Research International

Quartile SCImago

Quartile WOS

—

Impact factor

—

ISSN

23146133 (Print)
23146141 (Electronic)

Labs

Laboratory of Functional Biochemistry of the Nervous System

Profiles

Gulyaeva, Natalia V