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International Journal of Inflammation, volume 2019, pages 1-17

Morphological Characteristics of the Thymus and Spleen and the Subpopulation Composition of Lymphocytes in Peripheral Blood during Systemic Inflammatory Response in Male Rats with Different Resistance to Hypoxia

Dzhalilova Dzhuliia ¹

Kosyreva Anna ¹

Diatroptov Mikhail E ¹

Zolotova N A ¹

Tsvetkov Ivan Sergeevich ¹

Mkhitarov V A ¹

Makarova O. ¹

Khochanskiy D N ¹

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Department of Immunomorphology of Inflammation, Federal State Budgetary Scientific Institution “Research Institute of Human Morphology,” Tsyurupy St., 3, Moscow, Russia |

Publication type: Journal Article

Publication date: 2019-04-01

Hindawi Limited

Journal: International Journal of Inflammation

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Quartile WOS

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Impact factor: 2

ISSN: 20908040, 20420099

DOI: 10.1155/2019/7584685

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PubMed ID: 31057785

Immunology and Allergy

Abstract

On the model of the systemic inflammatory response (SIRS), induced by lipopolysaccharide (LPS), the morphological and functional changes in the thymus and spleen and the subpopulation composition of peripheral blood lymphocytes of rats differing in resistance to hypoxia were studied. It was demonstrated that the level of endotoxin in blood serum after 3 hours of LPS administration in susceptible-to-hypoxia rats was 64 times higher than in the control group, while in tolerant-to-hypoxia animals it was only 8 times higher in 6 hours. After 24 hours of LPS injection, only in susceptible-to-hypoxia rats did the level of C-reactive protein in blood serum increase. There is a difference in the dynamics of morphological changes of lymphoid organs after LPS injection in tolerant- and susceptible-to-hypoxia animals. After 3 hours of LPS administration, the tolerant-to-hypoxia rats showed no changes in the thymus, spleen, and subpopulation composition of lymphocytes in peripheral blood. After 6 hours there was only a decrease in B-lymphocytes and increase in cytotoxic T-lymphocytes and NK cells. After 1 day of LPS injection, the tolerant-to-hypoxia rats had devastation in PALS of the spleen. After 3 hours of LPS injection the susceptible-to-hypoxia animals had reactive changes in the lymphoid organs: decrease of the thymus cortex, narrowing of the marginal zones of spleen lymphoid follicles, widening of their germinal centers, and a decrease in the absolute number of cytotoxic T-lymphocytes, NK cells, and B-lymphocytes. After 24 hours of LPS injection the tolerant-to-hypoxia animals had a greater absolute number of T-lymphocytes and NK cells in comparison with the susceptible rats. Thus, in animals with different resistance to hypoxia the LPS-induced SIRS is characterized by different dynamics of morphological and functional changes of the thymus and spleen. The obtained data will serve as a basis for the development of new individual approaches to the prevention and treatment of infectious and inflammatory diseases.

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	1
Bulletin of Experimental Biology and Medicine	Bulletin of Experimental Biology and Medicine, 1, 12.5% Bulletin of Experimental Biology and Medicine 1 publication, 12.5%
Biomedicines	Biomedicines, 1, 12.5% Biomedicines 1 publication, 12.5%
Heliyon	Heliyon, 1, 12.5% Heliyon 1 publication, 12.5%
Materials Today Bio	Materials Today Bio, 1, 12.5% Materials Today Bio 1 publication, 12.5%
Food Reviews International	Food Reviews International, 1, 12.5% Food Reviews International 1 publication, 12.5%
Biochemistry (Moscow)	Biochemistry (Moscow), 1, 12.5% Biochemistry (Moscow) 1 publication, 12.5%
Inflammation	Inflammation, 1, 12.5% Inflammation 1 publication, 12.5%
PeerJ	PeerJ, 1, 12.5% PeerJ 1 publication, 12.5%
	1

Citations by publishers

	1 2
Springer Nature	Springer Nature, 2, 25% Springer Nature 2 publications, 25%
Elsevier	Elsevier, 2, 25% Elsevier 2 publications, 25%
Multidisciplinary Digital Publishing Institute (MDPI)	Multidisciplinary Digital Publishing Institute (MDPI), 1, 12.5% Multidisciplinary Digital Publishing Institute (MDPI) 1 publication, 12.5%
Taylor & Francis	Taylor & Francis, 1, 12.5% Taylor & Francis 1 publication, 12.5%
Pleiades Publishing	Pleiades Publishing, 1, 12.5% Pleiades Publishing 1 publication, 12.5%
PeerJ	PeerJ, 1, 12.5% PeerJ 1 publication, 12.5%
	1 2

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Dzhalilova D. et al. Morphological Characteristics of the Thymus and Spleen and the Subpopulation Composition of Lymphocytes in Peripheral Blood during Systemic Inflammatory Response in Male Rats with Different Resistance to Hypoxia // International Journal of Inflammation. 2019. Vol. 2019. pp. 1-17.

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Dzhalilova D., Kosyreva A., Diatroptov M. E., Zolotova N. A., Tsvetkov I. S., Mkhitarov V. A., Makarova O., Khochanskiy D. N. Morphological Characteristics of the Thymus and Spleen and the Subpopulation Composition of Lymphocytes in Peripheral Blood during Systemic Inflammatory Response in Male Rats with Different Resistance to Hypoxia // International Journal of Inflammation. 2019. Vol. 2019. pp. 1-17.

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RIS Copy

TY - JOUR

DO - 10.1155/2019/7584685

UR - https://doi.org/10.1155%2F2019%2F7584685

TI - Morphological Characteristics of the Thymus and Spleen and the Subpopulation Composition of Lymphocytes in Peripheral Blood during Systemic Inflammatory Response in Male Rats with Different Resistance to Hypoxia

T2 - International Journal of Inflammation

AU - Dzhalilova, Dzhuliia

AU - Kosyreva, Anna

AU - Diatroptov, Mikhail E

AU - Zolotova, N A

AU - Tsvetkov, Ivan Sergeevich

AU - Mkhitarov, V A

AU - Makarova, O.

AU - Khochanskiy, D N

PY - 2019

DA - 2019/04/01 00:00:00

PB - Hindawi Limited

SP - 1-17

VL - 2019

PMID - 31057785

SN - 2090-8040

SN - 2042-0099

ER -

BibTex

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BibTex Copy

@article{2019_Dzhalilova,

author = {Dzhuliia Dzhalilova and Anna Kosyreva and Mikhail E Diatroptov and N A Zolotova and Ivan Sergeevich Tsvetkov and V A Mkhitarov and O. Makarova and D N Khochanskiy},

title = {Morphological Characteristics of the Thymus and Spleen and the Subpopulation Composition of Lymphocytes in Peripheral Blood during Systemic Inflammatory Response in Male Rats with Different Resistance to Hypoxia},

journal = {International Journal of Inflammation},

year = {2019},

volume = {2019},

publisher = {Hindawi Limited},

month = {apr},

url = {https://doi.org/10.1155%2F2019%2F7584685},

pages = {1--17},

doi = {10.1155/2019/7584685}

}

Found error?

Publisher

Hindawi Limited

Journal

International Journal of Inflammation

Quartile SCImago

Quartile WOS

—

Impact factor

ISSN

20908040 (Print)
20420099 (Electronic)

Labs

Laboratory of Immunomorphology of Inflammation

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