UA62784, a novel inhibitor of centromere protein E kinesin-like protein
Тип публикации: Journal Article
Дата публикации: 2009-01-01
scimago Q1
wos Q1
white level БС1
SJR: 2.493
CiteScore: 11
Impact factor: 5.5
ISSN: 15357163, 15388514
PubMed ID:
19139111
Cancer Research
Oncology
Краткое описание
Pancreatic carcinoma is the fourth leading cause of death from cancer. Novel targets and therapeutic options are needed to aid in the treatment of pancreatic cancer. The compound UA62784 is a novel fluorenone with inhibitory activity against the centromere protein E (CENP-E) kinesin-like protein. UA62784 was isolated due to its selectivity in isogenic pancreatic carcinoma cell lines with a deletion of the DPC4 gene. UA62784 causes mitotic arrest by inhibiting chromosome congression at the metaphase plate likely through inhibition of the microtubule-associated ATPase activity of CENP-E. Furthermore, CENP-E binding to kinetochores during mitosis is not affected by UA62784, suggesting that the target lies within the motor domain of CENP-E. UA62784 is a novel specific inhibitor of CENP-E and its activity suggests a potential role for antimitotic drugs in treating pancreatic carcinomas. [Mol Cancer Ther 2009;8(1):36–44]
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Henderson M. C. et al. UA62784, a novel inhibitor of centromere protein E kinesin-like protein // Molecular Cancer Therapeutics. 2009. Vol. 8. No. 1. pp. 36-44.
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Henderson M. C., Shaw Y. J. Y., Wang H., Han H., Hurley L. H., FLYNN G., DORR R. T., Von Hoff D. D. UA62784, a novel inhibitor of centromere protein E kinesin-like protein // Molecular Cancer Therapeutics. 2009. Vol. 8. No. 1. pp. 36-44.
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TY - JOUR
DO - 10.1158/1535-7163.mct-08-0789
UR - https://doi.org/10.1158/1535-7163.mct-08-0789
TI - UA62784, a novel inhibitor of centromere protein E kinesin-like protein
T2 - Molecular Cancer Therapeutics
AU - Henderson, Meredith C
AU - Shaw, Yeng Jeng Y
AU - Wang, Hong
AU - Han, Haiyong
AU - Hurley, Laurence H.
AU - FLYNN, GARY
AU - DORR, ROBERT T.
AU - Von Hoff, Daniel D.
PY - 2009
DA - 2009/01/01
PB - American Association for Cancer Research (AACR)
SP - 36-44
IS - 1
VL - 8
PMID - 19139111
SN - 1535-7163
SN - 1538-8514
ER -
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@article{2009_Henderson,
author = {Meredith C Henderson and Yeng Jeng Y Shaw and Hong Wang and Haiyong Han and Laurence H. Hurley and GARY FLYNN and ROBERT T. DORR and Daniel D. Von Hoff},
title = {UA62784, a novel inhibitor of centromere protein E kinesin-like protein},
journal = {Molecular Cancer Therapeutics},
year = {2009},
volume = {8},
publisher = {American Association for Cancer Research (AACR)},
month = {jan},
url = {https://doi.org/10.1158/1535-7163.mct-08-0789},
number = {1},
pages = {36--44},
doi = {10.1158/1535-7163.mct-08-0789}
}
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MLA
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Henderson, Meredith C., et al. “UA62784, a novel inhibitor of centromere protein E kinesin-like protein.” Molecular Cancer Therapeutics, vol. 8, no. 1, Jan. 2009, pp. 36-44. https://doi.org/10.1158/1535-7163.mct-08-0789.
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