Ovid Technologies (Wolters Kluwer Health)

Circulation

, volume 147 , issue 11 , pages 867-876

Circulating Spike Protein Detected in Post–COVID-19 mRNA Vaccine Myocarditis

Lael M. Yonker ^{1, 2, 3}

Zoe Swank ^{3, 4}

Yannic C. Bartsch ^{3, 5}

Madeleine D. Burns ^{1, 2}

Abigail Kane ^{1, 2}

Brittany P. Boribong ^{1, 2, 3}

Jameson P. Davis ^{1, 2}

Maggie Loiselle ^{1, 2}

Tanya Novak ^{3, 6}

Yasmeen Senussi ^{3, 4, 7}

Chi-An Cheng ^{3, 4, 7}

Eleanor Burgess ⁵

Andrea G. Edlow ^{6, 8, 9}

Janet Chou ^{3, 10}

Audrey Dionne ^{3, 11}

Duraisamy Balaguru ^{2, 3}

Manuella Lahoud-Rahme ^{2, 3}

MOSHE ARDITI ¹²

Boris Julg ^{3, 5, 13}

A G Randolph ³

Galit Alter ^{3, 5}

Alessio Fasano ^{1, 2, 3}

David R. Walt ^{3, 4, 7}

Hide authors affiliations Show authors affiliations: 13 affiliations

Mucosal Immunology and Biology Research Center (L.M.Y., M.D.B., A.K., B.P.B., J.P.D., M.L., A.F.), Division of Infectious Disease, Massachusetts General Hospital, Boston. |

Department of Pediatrics (L.M.Y., M.D.B., A.K., B.P.B., J.P.D., M.L., D.B., M.L.-R., A.F.), Division of Infectious Disease, Massachusetts General Hospital, Boston. |

Harvard Medical School, Boston, MA (L.M.Y., Z.S., Y.C.B., B.P.B., T.N., Y.S., C.-A.C., J.C., A.D., D.B., M.L.-R., B.J., A.G.R., G.A., A.F., D.R.W.). |

⁴

Department of Pathology, Brigham and Women’s Hospital, Boston, MA (Z.S., Y.S., C.-A.C., D.R.W.). |

⁵

Ragon Institute of MGH, MIT and Harvard, Cambridge, MA (Y.C.B., E.B., B.J., G.A.). |

⁶

Department of Anesthesiology, Critical Care and Pain Medicine (T.N., A.G.R.), Boston Children’s Hospital, MA. |

⁷

Wyss Institute for Biologically Inspired Engineering, Harvard University, Boston, MA (Z.S., Y.S., C.-A.C., D.R.W.). |

⁸

Division of Maternal-Fetal Medicine, Department of Obstetrics and Gynecology (A.G.E.), Division of Infectious Disease, Massachusetts General Hospital, Boston. |

⁹

Vincent Center for Reproductive Biology (A.G.E.), Division of Infectious Disease, Massachusetts General Hospital, Boston. |

¹⁰

Department of Pediatrics, Division of Immunology (J.C.), Boston Children’s Hospital, MA. |

¹¹

Department of Cardiology (A.D.), Boston Children’s Hospital, MA. |

¹²

Department of Pediatrics, Division of Infectious Diseases and Immunology, Infectious and Immunologic Diseases Research Center, and Department of Biomedical Sciences, Cedars-Sinai Medical Center, Los Angeles, CA (M.A.). |

¹³

Department of Medicine (B.J.), Division of Infectious Disease, Massachusetts General Hospital, Boston. |

Publication type: Journal Article

Publication date: 2023-03-14

Ovid Technologies (Wolters Kluwer Health)

Circulation

scimago Q1

wos Q1

SJR: 8.668

CiteScore: 45.1

Impact factor: 38.6

ISSN: 00097322, 15244539

DOI: 10.1161/CIRCULATIONAHA.122.061025

Copy DOI

PubMed ID: 36597886

Cardiology and Cardiovascular Medicine

Physiology (medical)

Abstract

BACKGROUND:

Cases of adolescents and young adults developing myocarditis after vaccination with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)–targeted mRNA vaccines have been reported globally, but the underlying immunoprofiles of these individuals have not been described in detail.

METHODS:

From January 2021 through February 2022, we prospectively collected blood from 16 patients who were hospitalized at Massachusetts General for Children or Boston Children’s Hospital for myocarditis, presenting with chest pain with elevated cardiac troponin T after SARS-CoV-2 vaccination. We performed extensive antibody profiling, including tests for SARS-CoV-2–specific humoral responses and assessment for autoantibodies or antibodies against the human-relevant virome, SARS-CoV-2–specific T-cell analysis, and cytokine and SARS-CoV-2 antigen profiling. Results were compared with those from 45 healthy, asymptomatic, age-matched vaccinated control subjects.

RESULTS:

Extensive antibody profiling and T-cell responses in the individuals who developed postvaccine myocarditis were essentially indistinguishable from those of vaccinated control subjects, despite a modest increase in cytokine production. A notable finding was that markedly elevated levels of full-length spike protein (33.9±22.4 pg/mL), unbound by antibodies, were detected in the plasma of individuals with postvaccine myocarditis, whereas no free spike was detected in asymptomatic vaccinated control subjects (unpaired t test; P <0.0001).

CONCLUSIONS:

Immunoprofiling of vaccinated adolescents and young adults revealed that the mRNA vaccine–induced immune responses did not differ between individuals who developed myocarditis and individuals who did not. However, free spike antigen was detected in the blood of adolescents and young adults who developed post-mRNA vaccine myocarditis, advancing insight into its potential underlying cause.

Found

1 citation

Beltyukov Petr

25 publications, 224 citations

h-index: 7

Research Institute of Hygiene, Occupational Pathology and Human Ecology of the Federal Medical Biological Agency of Russia

1 citation

Alexandrova Svetlana

42 publications, 146 citations

h-index: 6

Federal State Budget Institution «A.N. Bakulev National Medical Research Center of Cardiovascular Surgery»

1 citation

Taradin Gennady

🥼 🤝

PhD in Health sciences, associate professor

55 publications, 113 citations

h-index: 4

Donetsk National Medical University

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GOST |

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GOST Copy

Yonker L. M. et al. Circulating Spike Protein Detected in Post–COVID-19 mRNA Vaccine Myocarditis // Circulation. 2023. Vol. 147. No. 11. pp. 867-876.

GOST all authors (up to 50) Copy

Yonker L. M. et al. Circulating Spike Protein Detected in Post–COVID-19 mRNA Vaccine Myocarditis // Circulation. 2023. Vol. 147. No. 11. pp. 867-876.

RIS |

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RIS Copy

TY - JOUR

DO - 10.1161/CIRCULATIONAHA.122.061025

UR - https://doi.org/10.1161/CIRCULATIONAHA.122.061025

TI - Circulating Spike Protein Detected in Post–COVID-19 mRNA Vaccine Myocarditis

T2 - Circulation

AU - Yonker, Lael M.

AU - Swank, Zoe

AU - Bartsch, Yannic C.

AU - Burns, Madeleine D.

AU - Kane, Abigail

AU - Boribong, Brittany P.

AU - Davis, Jameson P.

AU - Loiselle, Maggie

AU - Novak, Tanya

AU - Senussi, Yasmeen

AU - Cheng, Chi-An

AU - Burgess, Eleanor

AU - Edlow, Andrea G.

AU - Chou, Janet

AU - Dionne, Audrey

AU - Balaguru, Duraisamy

AU - Lahoud-Rahme, Manuella

AU - ARDITI, MOSHE

AU - Julg, Boris

AU - Randolph, A G

AU - Alter, Galit

AU - Fasano, Alessio

AU - Walt, David R.

PY - 2023

DA - 2023/03/14

PB - Ovid Technologies (Wolters Kluwer Health)

SP - 867-876

IS - 11

VL - 147

PMID - 36597886

SN - 0009-7322

SN - 1524-4539

ER -

BibTex |

Cite this

BibTex (up to 50 authors) Copy

@article{2023_Yonker,

author = {Lael M. Yonker and Zoe Swank and Yannic C. Bartsch and Madeleine D. Burns and Abigail Kane and Brittany P. Boribong and Jameson P. Davis and Maggie Loiselle and Tanya Novak and Yasmeen Senussi and Chi-An Cheng and Eleanor Burgess and Andrea G. Edlow and Janet Chou and Audrey Dionne and Duraisamy Balaguru and Manuella Lahoud-Rahme and MOSHE ARDITI and Boris Julg and A G Randolph and Galit Alter and Alessio Fasano and David R. Walt and others},

title = {Circulating Spike Protein Detected in Post–COVID-19 mRNA Vaccine Myocarditis},

journal = {Circulation},

year = {2023},

volume = {147},

publisher = {Ovid Technologies (Wolters Kluwer Health)},

month = {mar},

url = {https://doi.org/10.1161/CIRCULATIONAHA.122.061025},

number = {11},

pages = {867--876},

doi = {10.1161/CIRCULATIONAHA.122.061025}

}

MLA

Cite this

MLA Copy

Yonker, Lael M., et al. “Circulating Spike Protein Detected in Post–COVID-19 mRNA Vaccine Myocarditis.” Circulation, vol. 147, no. 11, Mar. 2023, pp. 867-876. https://doi.org/10.1161/CIRCULATIONAHA.122.061025.

Publisher

Ovid Technologies (Wolters Kluwer Health)

Journal

Circulation

scimago Q1

wos Q1

SJR

8.668

CiteScore

45.1

Impact factor

38.6

ISSN

00097322 (Print)

15244539 (Electronic)