Open Access
Open access
Wiley
Journal of the American Heart Association
,  volume 10 ,  issue 21

Satellite Cell Expression of RAGE (Receptor for Advanced Glycation end Products) Is Important for Collateral Vessel Formation

Laura M. Hansen 1, 2
, 
Giji Joseph 1
, 
Alejandra Valdivia 1
, 
W. Robert Taylor 1, 2, 3
1
 
2
 
Division of Cardiology Atlanta Veterans Affairs Medical Center Decatur GA | 
3
 
The Wallace H. Coulter Department of Biomedical Engineering Georgia Institute of Technology and Emory University Atlanta GA | 
Publication type: Journal Article
Publication date: 2021-10-23
Wiley
scimago Q1
wos Q1
SJR: 2.189
CiteScore: 8.5
Impact factor: 5.3
ISSN: 20479980
Cardiology and Cardiovascular Medicine
Abstract
Background
The growth and remodeling of vascular networks is an important component of the prognosis for patients with peripheral artery disease. One protein that has been previously implicated to play a role in this process is RAGE (receptor for advanced glycation end products). This study sought to determine the cellular source of RAGE in the ischemic hind limb and the role of RAGE signaling in this cell type.
Methods and Results
Using a hind limb ischemia model of vascular growth, this study found skeletal muscle satellite cells to be a novel major cellular source of RAGE in ischemic tissue by both staining and cellular sorting. Although wild‐type satellite cells increased tumor necrosis factor‐α and monocyte chemoattractant protein‐1 production in response to ischemia in vivo and a RAGE ligand in vitro, satellite cells from RAGE knockout mice lacked the increase in cytokine production both in vivo in response to ischemia and in vitro after stimuli with the RAGE ligand high‐mobility group box 1. Furthermore, encapsulated wild‐type satellite cells improved perfusion after hind limb ischemia surgery by both perfusion staining and vessel quantification, but RAGE knockout satellite cells provided no improvement over empty capsules.
Conclusions
Thus, RAGE expression and signaling in satellite cells is crucial for their response to stimuli and angiogenic and arteriogenic functions.
Found 
Found 

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GOST Copy
Hansen L. M. et al. Satellite Cell Expression of RAGE (Receptor for Advanced Glycation end Products) Is Important for Collateral Vessel Formation // Journal of the American Heart Association. 2021. Vol. 10. No. 21.
GOST all authors (up to 50) Copy
Hansen L. M., Joseph G., Valdivia A., Taylor W. R. Satellite Cell Expression of RAGE (Receptor for Advanced Glycation end Products) Is Important for Collateral Vessel Formation // Journal of the American Heart Association. 2021. Vol. 10. No. 21.
RIS |
Cite this
RIS Copy
TY - JOUR
DO - 10.1161/JAHA.120.022127
UR - https://doi.org/10.1161/JAHA.120.022127
TI - Satellite Cell Expression of RAGE (Receptor for Advanced Glycation end Products) Is Important for Collateral Vessel Formation
T2 - Journal of the American Heart Association
AU - Hansen, Laura M.
AU - Joseph, Giji
AU - Valdivia, Alejandra
AU - Taylor, W. Robert
PY - 2021
DA - 2021/10/23
PB - Wiley
IS - 21
VL - 10
PMID - 34689598
SN - 2047-9980
ER -
BibTex
Cite this
BibTex (up to 50 authors) Copy
@article{2021_Hansen,
author = {Laura M. Hansen and Giji Joseph and Alejandra Valdivia and W. Robert Taylor},
title = {Satellite Cell Expression of RAGE (Receptor for Advanced Glycation end Products) Is Important for Collateral Vessel Formation},
journal = {Journal of the American Heart Association},
year = {2021},
volume = {10},
publisher = {Wiley},
month = {oct},
url = {https://doi.org/10.1161/JAHA.120.022127},
number = {21},
doi = {10.1161/JAHA.120.022127}
}