Open Access
Open access
Wiley
Journal of the American Heart Association
,  volume 12 ,  issue 21

Association Between the Liver Fibrosis Markers and Scores, and Hemodynamic Congestion Assessed by Peripheral Venous Pressure in Patients With Acute Heart Failure

Kazuya Nagao 1, 2
, 
SHIORI Maruichi-Kawakami 1
, 
KENJI AIDA 1
, 
Kenichi Matsuto 1
, 
Kazumasa Imamoto 1
, 
Hiroshi Yukawa 1
, 
Takenori Kanazawa 1
, 
Yohei Kobayashi 1
, 
Naoki Takahashi 1
, 
Haruyasu Ito 1
, 
Fujio Hayashi 1
, 
Tsukasa Inada 1
1
 
2
 
Publication type: Journal Article
Publication date: 2023-11-07
Wiley
scimago Q1
wos Q1
SJR: 2.189
CiteScore: 8.5
Impact factor: 5.3
ISSN: 20479980
Cardiology and Cardiovascular Medicine
Abstract
Background
Peripheral venous pressure (PVP) has been shown to be a reliable surrogate for right atrial pressure in assessing congestion in patients with heart failure (HF). Liver fibrosis markers and scores can be useful in assessing organ injury in patients with acute HF. This study aimed to investigate the association of liver fibrosis markers and scores with PVP in patients with acute HF.
Methods and Results
The 7S domain of the collagen type IV N‐terminal propeptide (P4NP 7S), aspartate aminotransferase‐to‐platelet ratio index, fibrosis‐4, and nonalcoholic fatty liver disease fibrosis score were determined along with PVP measurements before discharge in 229 patients with acute HF. The strongest correlation with PVP was found for P4NP 7S (Pearson r =0.40). Patients with high P4NP 7S levels (≥median [6.2 ng/mL]) had an increased risk of cardiovascular death or HF hospitalization (adjusted hazard ratio [HR], 1.80 [95% CI, 1.09–3.04], P =0.02). The concomitant high PVP (≥mean [8 mm Hg])/high P4NP 7S group, in contrast to the high PVP/low P4NP 7S or low PVP/high P4NP 7S group, had a significant risk relative to the low PVP/low P4NP 7S group for cardiovascular death or HF hospitalization (adjusted HR, 2.63 [95% CI, 1.43–5.05], P =0.002). A sustained elevation in PVP for 1 month postdischarge was associated with a persistent increase in P4NP 7S.
Conclusions
The study demonstrated the relationship between the liver fibrosis marker P4NP 7S and congestion. PVP and P4NP 7S could be useful for assessing congestion‐related organ injury and predicting prognosis in patients with acute HF.
Found 
Found 

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GOST Copy
Nagao K. et al. Association Between the Liver Fibrosis Markers and Scores, and Hemodynamic Congestion Assessed by Peripheral Venous Pressure in Patients With Acute Heart Failure // Journal of the American Heart Association. 2023. Vol. 12. No. 21.
GOST all authors (up to 50) Copy
Nagao K., Maruichi-Kawakami S., AIDA K., Matsuto K., Imamoto K., Yukawa H., Kanazawa T., Kobayashi Y., Takahashi N., Ito H., Hayashi F., Inada T. Association Between the Liver Fibrosis Markers and Scores, and Hemodynamic Congestion Assessed by Peripheral Venous Pressure in Patients With Acute Heart Failure // Journal of the American Heart Association. 2023. Vol. 12. No. 21.
RIS |
Cite this
RIS Copy
TY - JOUR
DO - 10.1161/jaha.123.030788
UR - https://doi.org/10.1161/jaha.123.030788
TI - Association Between the Liver Fibrosis Markers and Scores, and Hemodynamic Congestion Assessed by Peripheral Venous Pressure in Patients With Acute Heart Failure
T2 - Journal of the American Heart Association
AU - Nagao, Kazuya
AU - Maruichi-Kawakami, SHIORI
AU - AIDA, KENJI
AU - Matsuto, Kenichi
AU - Imamoto, Kazumasa
AU - Yukawa, Hiroshi
AU - Kanazawa, Takenori
AU - Kobayashi, Yohei
AU - Takahashi, Naoki
AU - Ito, Haruyasu
AU - Hayashi, Fujio
AU - Inada, Tsukasa
PY - 2023
DA - 2023/11/07
PB - Wiley
IS - 21
VL - 12
PMID - 37929710
SN - 2047-9980
ER -
BibTex
Cite this
BibTex (up to 50 authors) Copy
@article{2023_Nagao,
author = {Kazuya Nagao and SHIORI Maruichi-Kawakami and KENJI AIDA and Kenichi Matsuto and Kazumasa Imamoto and Hiroshi Yukawa and Takenori Kanazawa and Yohei Kobayashi and Naoki Takahashi and Haruyasu Ito and Fujio Hayashi and Tsukasa Inada},
title = {Association Between the Liver Fibrosis Markers and Scores, and Hemodynamic Congestion Assessed by Peripheral Venous Pressure in Patients With Acute Heart Failure},
journal = {Journal of the American Heart Association},
year = {2023},
volume = {12},
publisher = {Wiley},
month = {nov},
url = {https://doi.org/10.1161/jaha.123.030788},
number = {21},
doi = {10.1161/jaha.123.030788}
}