Open Access
Open access
Ovid Technologies (Wolters Kluwer Health)
Journal of the American Heart Association
,  volume 14 ,  issue 5

Temporal Trends in Stroke Management and Outcomes Between 2011 and 2020 in South Korea: Results From a Nationwide Multicenter Registry

Tai Hwan Park 1, 2
, 
Keun-Sik Hong 3, 4
, 
Yong-Jin Cho 3, 4
, 
Wi-Sun Ryu 5, 6
, 
Dong-Eog Kim 5, 6
, 
Man‐Seok Park 7, 8
, 
Seong-Min Choi 7, 8
, 
Joon-Tae Kim 7, 8
, 
Ji-Hoon Kang 9, 10
, 
Beom Joon Kim 9, 10
, 
Moon-Ku Han 9, 10
, 
Jun Lee 11, 12
, 
Jae-Kwan Cha 13, 14
, 
Dae-Hyun Kim 13, 14
, 
Jae Guk Kim 15, 16
, 
Soo Joo Lee 15, 16
, 
Jee-Hyun Kwon 17, 18
, 
Wook-Joo Kim 17, 18
, 
Dong-Ick Shin 19, 20
, 
Kyu Sun Yum 19, 20
, 
Sung Keun Sohn 21, 22
, 
Jeong-Ho Hong 21, 22
, 
Jay Chol Choi 23, 24
, 
Byung-Chul Lee 25, 26
, 
Kyung-Ho Yu 25, 26
, 
Mi-Sun Oh 25, 26
, 
Jong-Moo Park 27, 28
, 
Kyusik Kang 29, 30
, 
Kyung Bok Lee 31, 32
, 
Sang-Hwa Lee 33, 34
, 
Hae-Bong Jeong 35, 36
, 
K.-Y. Park 35, 36
, 
Ji Sung Lee 37, 38
, 
Juneyoung Lee 39, 40
, 
Philip B. Gorelick 41, 42
, 
Hee Joon Bae 9, 10
1
 
Department of Neurology Seoul Medical Center Seoul Korea | 
2
 
Seoul medical center | 
3
 
4
 
5
 
6
 
7
 
8
 
9
 
10
 
11
 
12
 
13
 
Department of Neurology Dong‐A University Hospital Busan Korea | 
14
 
Dong‐A University Hospital
15
 
16
 
17
 
Department of Neurology Ulsan University College of Medicine Ulsan Korea | 
18
 
Ulsan University College of Medicine | 
19
 
20
 
21
 
22
 
23
 
24
 
25
 
26
 
27
 
28
 
29
 
30
 
31
 
32
 
33
 
34
 
35
 
36
 
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38
 
Clinical Research Center
39
 
40
 
41
 
42
 
Publication type: Journal Article
Publication date: 2025-03-04
Ovid Technologies (Wolters Kluwer Health)
scimago Q1
wos Q1
SJR: 2.189
CiteScore: 8.5
Impact factor: 5.3
ISSN: 20479980
Abstract
Background
This study aims to evaluate temporal trends of advanced treatments and related clinical outcomes of ischemic stroke through a decade‐long trend analysis, using data from a comprehensive, national, multicenter registry. We also seek to identify areas in need of improvement.
Methods and Results
This analysis involved patients with ischemic stroke or transient ischemic attack registered prospectively in the CRCS‐K‐NIH (Clinical Research Center for Stroke in Korea–National Institute of Health) registry between 2011 and 2020. We examined temporal trends in risk factors, pathogenetic subtypes, acute management strategies, and outcomes for up to 1 year following a stroke. Generalized linear mixed models were used to account for center clustering. The average age of 77 662 patients increased 2.2 years in men and 2.4 years in women over the 10‐year follow‐up. Notably, in‐hospital neurological deterioration, 3‐month and 1‐year mortality rate, and cumulative incidence of recurrent stroke within 1‐year decreased over time after adjustments for age, sex, and initial stroke severity ( P <0.01). However, functional outcomes at 3 months and 1 year remained unchanged. Endovascular thrombectomy increased from 5.4% in 2011 to 10.6% in 2020. Use of anticoagulants for atrial fibrillation, dual antiplatelet therapy, statins, and stroke unit care also increased. Contrarily, the rate of intravenous thrombolysis showed a slight decline.
Conclusions
This study points to a reduction in death and risk of recurrent stroke over the past decade, paralleling enhancement in acute and preventive stroke management. Nevertheless, the decline in the use of intravenous thrombolysis and the lack of improvement in functional outcomes following stroke are concerning trends that warrant thorough investigation.
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Park T. H. et al. Temporal Trends in Stroke Management and Outcomes Between 2011 and 2020 in South Korea: Results From a Nationwide Multicenter Registry // Journal of the American Heart Association. 2025. Vol. 14. No. 5.
GOST all authors (up to 50) Copy
Park T. H. et al. Temporal Trends in Stroke Management and Outcomes Between 2011 and 2020 in South Korea: Results From a Nationwide Multicenter Registry // Journal of the American Heart Association. 2025. Vol. 14. No. 5.
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RIS Copy
TY - JOUR
DO - 10.1161/jaha.124.035218
UR - https://www.ahajournals.org/doi/10.1161/JAHA.124.035218
TI - Temporal Trends in Stroke Management and Outcomes Between 2011 and 2020 in South Korea: Results From a Nationwide Multicenter Registry
T2 - Journal of the American Heart Association
AU - Park, Tai Hwan
AU - Hong, Keun-Sik
AU - Cho, Yong-Jin
AU - Ryu, Wi-Sun
AU - Kim, Dong-Eog
AU - Park, Man‐Seok
AU - Choi, Seong-Min
AU - Kim, Joon-Tae
AU - Kang, Ji-Hoon
AU - Kim, Beom Joon
AU - Han, Moon-Ku
AU - Lee, Jun
AU - Cha, Jae-Kwan
AU - Kim, Dae-Hyun
AU - Kim, Jae Guk
AU - Lee, Soo Joo
AU - Kwon, Jee-Hyun
AU - Kim, Wook-Joo
AU - Shin, Dong-Ick
AU - Yum, Kyu Sun
AU - Sohn, Sung Keun
AU - Hong, Jeong-Ho
AU - Choi, Jay Chol
AU - Lee, Byung-Chul
AU - Yu, Kyung-Ho
AU - Oh, Mi-Sun
AU - Park, Jong-Moo
AU - Kang, Kyusik
AU - Lee, Kyung Bok
AU - Lee, Sang-Hwa
AU - Jeong, Hae-Bong
AU - Park, K.-Y.
AU - Lee, Ji Sung
AU - Lee, Juneyoung
AU - Gorelick, Philip B.
AU - Bae, Hee Joon
PY - 2025
DA - 2025/03/04
PB - Ovid Technologies (Wolters Kluwer Health)
IS - 5
VL - 14
SN - 2047-9980
ER -
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@article{2025_Park,
author = {Tai Hwan Park and Keun-Sik Hong and Yong-Jin Cho and Wi-Sun Ryu and Dong-Eog Kim and Man‐Seok Park and Seong-Min Choi and Joon-Tae Kim and Ji-Hoon Kang and Beom Joon Kim and Moon-Ku Han and Jun Lee and Jae-Kwan Cha and Dae-Hyun Kim and Jae Guk Kim and Soo Joo Lee and Jee-Hyun Kwon and Wook-Joo Kim and Dong-Ick Shin and Kyu Sun Yum and Sung Keun Sohn and Jeong-Ho Hong and Jay Chol Choi and Byung-Chul Lee and Kyung-Ho Yu and Mi-Sun Oh and Jong-Moo Park and Kyusik Kang and Kyung Bok Lee and Sang-Hwa Lee and Hae-Bong Jeong and K.-Y. Park and Ji Sung Lee and Juneyoung Lee and Philip B. Gorelick and Hee Joon Bae and others},
title = {Temporal Trends in Stroke Management and Outcomes Between 2011 and 2020 in South Korea: Results From a Nationwide Multicenter Registry},
journal = {Journal of the American Heart Association},
year = {2025},
volume = {14},
publisher = {Ovid Technologies (Wolters Kluwer Health)},
month = {mar},
url = {https://www.ahajournals.org/doi/10.1161/JAHA.124.035218},
number = {5},
doi = {10.1161/jaha.124.035218}
}