Open Access
Open access
Ovid Technologies (Wolters Kluwer Health)
Journal of the American Heart Association
,  volume 13 ,  issue 24

Brachial‐Ankle Pulse Wave Velocity as a Predictor of Diabetes Development: Elevated Risk Within Normal Range Values in a Low‐Risk Population

Jeong Gyu Kang 1, 2
, 
Ki-Hyun Jeon 3
, 
Kang Un Choi 4
, 
Hyo-In Choi 5
, 
Ki-Chul Sung 5
1
 
2
 
3
 
4
 
5
 
Publication type: Journal Article
Publication date: 2024-12-17
Ovid Technologies (Wolters Kluwer Health)
scimago Q1
wos Q1
SJR: 2.189
CiteScore: 8.5
Impact factor: 5.3
ISSN: 20479980
Abstract
Background
Recent studies have suggested that increased brachial‐ankle pulse wave velocity (baPWV) is a risk factor for diabetes. Exploring its relationship with insulin resistance is of interest, necessitating further studies across different sexes and age groups.
Methods and Results
This cohort study involved 119 170 Korean adults with an average age of 39.8 years, none of whom had diabetes at baseline. As part of a health screening, baPWV measurements were taken. Over a median follow‐up period of 5.6 years, fasting blood glucose, glycated hemoglobin, insulin levels, and questionnaire responses were collected. The risk of developing diabetes was evaluated using a flexible parametric proportional hazards model with data stratified by sex and age group (<40 versus ≥40 years). During the follow‐up period, diabetes was diagnosed in 5966 participants (5.0%). A fully adjusted model found that the hazard ratios for diabetes onset associated with baPWV quartiles Q2 (1171.0–1270.5 cm/s), Q3 (1271.0–1376.0 cm/s), and Q4 (≥1376.5 cm/s) compared with Q1 (<1171.0 cm/s) were 1.06 (95% CI, 0.96–1.17), 1.25 (1.14–1.38), and 1.48 (1.34–1.62), respectively ( P for trend <0.001). A significant sex‐based interaction was noted in this association, with women showing a higher risk of diabetes development. Furthermore, higher baPWV quartiles were associated with an increased risk of developing insulin resistance, defined as the homeostatic model assessment of insulin resistance.
Conclusions
These findings highlight the importance of arterial stiffness, as measured by elevated baPWV, in the development of diabetes and insulin resistance. Notably, this study highlighted a strong association, particularly among women.
Found 

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Kang J. G. et al. Brachial‐Ankle Pulse Wave Velocity as a Predictor of Diabetes Development: Elevated Risk Within Normal Range Values in a Low‐Risk Population // Journal of the American Heart Association. 2024. Vol. 13. No. 24.
GOST all authors (up to 50) Copy
Kang J. G., Jeon K., Choi K. U., Choi H., Sung K. Brachial‐Ankle Pulse Wave Velocity as a Predictor of Diabetes Development: Elevated Risk Within Normal Range Values in a Low‐Risk Population // Journal of the American Heart Association. 2024. Vol. 13. No. 24.
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RIS Copy
TY - JOUR
DO - 10.1161/jaha.124.037705
UR - https://www.ahajournals.org/doi/10.1161/JAHA.124.037705
TI - Brachial‐Ankle Pulse Wave Velocity as a Predictor of Diabetes Development: Elevated Risk Within Normal Range Values in a Low‐Risk Population
T2 - Journal of the American Heart Association
AU - Kang, Jeong Gyu
AU - Jeon, Ki-Hyun
AU - Choi, Kang Un
AU - Choi, Hyo-In
AU - Sung, Ki-Chul
PY - 2024
DA - 2024/12/17
PB - Ovid Technologies (Wolters Kluwer Health)
IS - 24
VL - 13
PMID - 39655725
SN - 2047-9980
ER -
BibTex
Cite this
BibTex (up to 50 authors) Copy
@article{2024_Kang,
author = {Jeong Gyu Kang and Ki-Hyun Jeon and Kang Un Choi and Hyo-In Choi and Ki-Chul Sung},
title = {Brachial‐Ankle Pulse Wave Velocity as a Predictor of Diabetes Development: Elevated Risk Within Normal Range Values in a Low‐Risk Population},
journal = {Journal of the American Heart Association},
year = {2024},
volume = {13},
publisher = {Ovid Technologies (Wolters Kluwer Health)},
month = {dec},
url = {https://www.ahajournals.org/doi/10.1161/JAHA.124.037705},
number = {24},
doi = {10.1161/jaha.124.037705}
}