Clonal hematopoiesis, with and without candidate driver mutations, is common in the elderly
Florian Zink
1
,
Simon N Stacey
1
,
Gudmundur L Norddahl
1
,
Michael L. Frigge
1
,
Olafur T Magnusson
1
,
Ingileif Jonsdottir
1, 2, 3
,
Thorgeir E. Thorgeirsson
1
,
Asgeir Sigurdsson
1
,
Sigurjon A Gudjonsson
1
,
Julius Gudmundsson
1
,
Jon G. Jonasson
2, 3, 4
,
Laufey Tryggvadóttir
4
,
Thorvaldur Jonsson
2, 3
,
Agnar Helgason
1, 5
,
Arnaldur Gylfason
1
,
Patrick Sulem
1
,
Thorunn Rafnar
1
,
Unnur Thorsteinsdottir
1, 3
,
Daniel F. Gudbjartsson
1, 6
,
Gisli Masson
1
,
Augustine Kong
1
,
Kari Stefansson
1, 3
1
deCODE genetics/AMGEN, Reykjavik, Iceland;
|
4
Icelandic Cancer Registry, Reykjavik, Iceland; and
|
5
Department of Anthropology and
Publication type: Journal Article
Publication date: 2017-08-10
scimago Q1
wos Q1
SJR: 5.823
CiteScore: 23.0
Impact factor: 23.1
ISSN: 00064971, 15280020
PubMed ID:
28483762
Biochemistry
Cell Biology
Immunology
Hematology
Abstract
Key Points
Whole-genome sequencing of 11 262 Icelanders reveals that clonal hematopoiesis is very common in the elderly. Somatic mutation of some genes is strongly associated with clonal hematopoiesis, but in most cases, no driver mutations were evident.
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Total citations:
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Citations from 2024:
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GOST
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Zink F. et al. Clonal hematopoiesis, with and without candidate driver mutations, is common in the elderly // Blood. 2017. Vol. 130. No. 6. pp. 742-752.
GOST all authors (up to 50)
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Zink F., Stacey S. N., Norddahl G. L., Frigge M. L., Magnusson O. T., Jonsdottir I., Thorgeirsson T. E., Sigurdsson A., Gudjonsson S. A., Gudmundsson J., Jonasson J. G., Tryggvadóttir L., Jonsson T., Helgason A., Gylfason A., Sulem P., Rafnar T., Thorsteinsdottir U., Gudbjartsson D. F., Masson G., Kong A., Stefansson K. Clonal hematopoiesis, with and without candidate driver mutations, is common in the elderly // Blood. 2017. Vol. 130. No. 6. pp. 742-752.
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TY - JOUR
DO - 10.1182/blood-2017-02-769869
UR - https://doi.org/10.1182/blood-2017-02-769869
TI - Clonal hematopoiesis, with and without candidate driver mutations, is common in the elderly
T2 - Blood
AU - Zink, Florian
AU - Stacey, Simon N
AU - Norddahl, Gudmundur L
AU - Frigge, Michael L.
AU - Magnusson, Olafur T
AU - Jonsdottir, Ingileif
AU - Thorgeirsson, Thorgeir E.
AU - Sigurdsson, Asgeir
AU - Gudjonsson, Sigurjon A
AU - Gudmundsson, Julius
AU - Jonasson, Jon G.
AU - Tryggvadóttir, Laufey
AU - Jonsson, Thorvaldur
AU - Helgason, Agnar
AU - Gylfason, Arnaldur
AU - Sulem, Patrick
AU - Rafnar, Thorunn
AU - Thorsteinsdottir, Unnur
AU - Gudbjartsson, Daniel F.
AU - Masson, Gisli
AU - Kong, Augustine
AU - Stefansson, Kari
PY - 2017
DA - 2017/08/10
PB - American Society of Hematology
SP - 742-752
IS - 6
VL - 130
PMID - 28483762
SN - 0006-4971
SN - 1528-0020
ER -
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BibTex (up to 50 authors)
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@article{2017_Zink,
author = {Florian Zink and Simon N Stacey and Gudmundur L Norddahl and Michael L. Frigge and Olafur T Magnusson and Ingileif Jonsdottir and Thorgeir E. Thorgeirsson and Asgeir Sigurdsson and Sigurjon A Gudjonsson and Julius Gudmundsson and Jon G. Jonasson and Laufey Tryggvadóttir and Thorvaldur Jonsson and Agnar Helgason and Arnaldur Gylfason and Patrick Sulem and Thorunn Rafnar and Unnur Thorsteinsdottir and Daniel F. Gudbjartsson and Gisli Masson and Augustine Kong and Kari Stefansson},
title = {Clonal hematopoiesis, with and without candidate driver mutations, is common in the elderly},
journal = {Blood},
year = {2017},
volume = {130},
publisher = {American Society of Hematology},
month = {aug},
url = {https://doi.org/10.1182/blood-2017-02-769869},
number = {6},
pages = {742--752},
doi = {10.1182/blood-2017-02-769869}
}
Cite this
MLA
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Zink, Florian, et al. “Clonal hematopoiesis, with and without candidate driver mutations, is common in the elderly.” Blood, vol. 130, no. 6, Aug. 2017, pp. 742-752. https://doi.org/10.1182/blood-2017-02-769869.