Open Access
BMC Genomics, volume 14, issue 1, pages 726
DNA repair in Mycoplasma gallisepticum
Fisunov Gleb Y
1
,
Izraelson Mark
1
,
Evsyutina Darya V
1
,
Mazin Pavel V
1, 2
,
Alexeev Dmitry G
1, 3
,
Pobeguts Olga V
1
,
Gorshkova Tatyana N
1
,
Kovalchuk Sergey I.
4
,
Kamashev Dmitry E
1
,
GOVORUN VADIM M.
1, 3, 4
Publication type: Journal Article
Publication date: 2013-10-23
Genetics
Biotechnology
Abstract
DNA repair is essential for the maintenance of genome stability in all living beings. Genome size as well as the repertoire and abundance of DNA repair components may vary among prokaryotic species. The bacteria of the Mollicutes class feature a small genome size, absence of a cell wall, and a parasitic lifestyle. A small number of genes make Mollicutes a good model for a “minimal cell” concept. In this work we studied the DNA repair system of Mycoplasma gallisepticum on genomic, transcriptional, and proteomic levels. We detected 18 out of 22 members of the DNA repair system on a protein level. We found that abundance of the respective mRNAs is less than one per cell. We studied transcriptional response of DNA repair genes of M. gallisepticum at stress conditions including heat, osmotic, peroxide stresses, tetracycline and ciprofloxacin treatment, stationary phase and heat stress in stationary phase. Based on comparative genomic study, we determined that the DNA repair system M. gallisepticum includes a sufficient set of proteins to provide a cell with functional nucleotide and base excision repair and mismatch repair. We identified SOS-response in M. gallisepticum on ciprofloxacin, which is a known SOS-inducer, tetracycline and heat stress in the absence of established regulators. Heat stress was found to be the strongest SOS-inducer. We found that upon transition to stationary phase of culture growth transcription of DNA repair genes decreases dramatically. Heat stress does not induce SOS-response in a stationary phase.
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Citations by publishers
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1 publication, 3.7%
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1 publication, 3.7%
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Taylor & Francis
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1 publication, 3.7%
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1 publication, 3.7%
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1 publication, 3.7%
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- We do not take into account publications that without a DOI.
- Statistics recalculated only for publications connected to researchers, organizations and labs registered on the platform.
- Statistics recalculated weekly.
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GOST
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Gorbachev A. Y. et al. DNA repair in Mycoplasma gallisepticum // BMC Genomics. 2013. Vol. 14. No. 1. p. 726.
GOST all authors (up to 50)
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Gorbachev A. Y., Fisunov G. Y., Izraelson M., Evsyutina D. V., Mazin P. V., Alexeev D. G., Pobeguts O. V., Gorshkova T. N., Kovalchuk S., Kamashev D. E., GOVORUN V. M. DNA repair in Mycoplasma gallisepticum // BMC Genomics. 2013. Vol. 14. No. 1. p. 726.
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RIS
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TY - JOUR
DO - 10.1186/1471-2164-14-726
UR - https://doi.org/10.1186%2F1471-2164-14-726
TI - DNA repair in Mycoplasma gallisepticum
T2 - BMC Genomics
AU - Gorbachev, Alexey Y
AU - Fisunov, Gleb Y
AU - Izraelson, Mark
AU - Evsyutina, Darya V
AU - Mazin, Pavel V
AU - Alexeev, Dmitry G
AU - Pobeguts, Olga V
AU - Gorshkova, Tatyana N
AU - Kovalchuk, Sergey I.
AU - Kamashev, Dmitry E
AU - GOVORUN, VADIM M.
PY - 2013
DA - 2013/10/23 00:00:00
PB - Springer Nature
SP - 726
IS - 1
VL - 14
SN - 1471-2164
ER -
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@article{2013_Gorbachev,
author = {Alexey Y Gorbachev and Gleb Y Fisunov and Mark Izraelson and Darya V Evsyutina and Pavel V Mazin and Dmitry G Alexeev and Olga V Pobeguts and Tatyana N Gorshkova and Sergey I. Kovalchuk and Dmitry E Kamashev and VADIM M. GOVORUN},
title = {DNA repair in Mycoplasma gallisepticum},
journal = {BMC Genomics},
year = {2013},
volume = {14},
publisher = {Springer Nature},
month = {oct},
url = {https://doi.org/10.1186%2F1471-2164-14-726},
number = {1},
pages = {726},
doi = {10.1186/1471-2164-14-726}
}
Cite this
MLA
Copy
Gorbachev, Alexey Y., et al. “DNA repair in Mycoplasma gallisepticum.” BMC Genomics, vol. 14, no. 1, Oct. 2013, p. 726. https://doi.org/10.1186%2F1471-2164-14-726.
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