Open Access
A defined road to tracheal reconstruction: laser structuring and cell support for rapid clinic translation
Alexey Fayzullin
1
,
Georgiy Vladimirov
1
,
Elvira Gafarova
1, 3
,
Sergei Tkachev
1
,
Nastasia Kosheleva
1, 4
,
Elena Istranova
1
,
Leonid Istranov
1
,
Yuri Efremov
1
,
Ivan Novikov
5
,
Polina Bikmulina
3
,
Kirill Puzakov
6
,
Pavel Petrov
7
,
Ivan Vyazankin
7
,
Andrey Nedorubov
8
,
Tatyana Khlebnikova
1
,
Valentina Kapustina
9
,
Pavel Trubnikov
8
,
Nikita Minaev
10
,
Aleksandr Kurkov
1
,
Valery Royuk
11
,
Vasily Mikhailov
12
,
Dmitriy Parshin
13
,
Anna Solovieva
2
,
Marina Lipina
7
,
Alexey Lychagin
7
,
Petr S. Timashev
1, 3
,
Andrey Svistunov
14
,
Victor Fomin
9, 14
,
Anastasia Shpichka
1, 3
7
10
Publication type: Journal Article
Publication date: 2022-07-16
scimago Q1
wos Q1
SJR: 2.021
CiteScore: 13.3
Impact factor: 7.3
ISSN: 17576512
PubMed ID:
35842689
Medicine (miscellaneous)
Cell Biology
Molecular Medicine
Biochemistry, Genetics and Molecular Biology (miscellaneous)
Abstract
One of the severe complications occurring because of the patient’s intubation is tracheal stenosis. Its incidence has significantly risen because of the COVID-19 pandemic and tends only to increase. Here, we propose an alternative to the donor trachea and synthetic prostheses—the tracheal equivalent. To form it, we applied the donor trachea samples, which were decellularized, cross-linked, and treated with laser to make wells on their surface, and inoculated them with human gingiva-derived mesenchymal stromal cells. The fabricated construct was assessed in vivo using nude (immunodeficient), immunosuppressed, and normal mice and rabbits. In comparison with the matrix ones, the tracheal equivalent samples demonstrated the thinning of the capsule, the significant vessel ingrowth into surrounding tissues, and the increase in the submucosa resorption. The developed construct was shown to be highly biocompatible and efficient in trachea restoration. These results can facilitate its clinical translation and be a base to design clinical trials.
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Metrics
12
Total citations:
12
Citations from 2024:
7
(58.33%)
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GOST
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Fayzullin A. et al. A defined road to tracheal reconstruction: laser structuring and cell support for rapid clinic translation // Stem Cell Research and Therapy. 2022. Vol. 13. No. 1. 317
GOST all authors (up to 50)
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Fayzullin A., Vladimirov G., Kuryanova A., Gafarova E., Tkachev S., Kosheleva N., Istranova E., Istranov L., Efremov Y., Novikov I., Bikmulina P., Puzakov K., Petrov P., Vyazankin I., Nedorubov A., Khlebnikova T., Kapustina V., Trubnikov P., Minaev N., Kurkov A., Royuk V., Mikhailov V., Parshin D., Solovieva A., Lipina M., Lychagin A., Timashev P. S., Svistunov A., Fomin V., Shpichka A. A defined road to tracheal reconstruction: laser structuring and cell support for rapid clinic translation // Stem Cell Research and Therapy. 2022. Vol. 13. No. 1. 317
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TY - JOUR
DO - 10.1186/s13287-022-02997-8
UR - https://stemcellres.biomedcentral.com/articles/10.1186/s13287-022-02997-8
TI - A defined road to tracheal reconstruction: laser structuring and cell support for rapid clinic translation
T2 - Stem Cell Research and Therapy
AU - Fayzullin, Alexey
AU - Vladimirov, Georgiy
AU - Kuryanova, Anastasia
AU - Gafarova, Elvira
AU - Tkachev, Sergei
AU - Kosheleva, Nastasia
AU - Istranova, Elena
AU - Istranov, Leonid
AU - Efremov, Yuri
AU - Novikov, Ivan
AU - Bikmulina, Polina
AU - Puzakov, Kirill
AU - Petrov, Pavel
AU - Vyazankin, Ivan
AU - Nedorubov, Andrey
AU - Khlebnikova, Tatyana
AU - Kapustina, Valentina
AU - Trubnikov, Pavel
AU - Minaev, Nikita
AU - Kurkov, Aleksandr
AU - Royuk, Valery
AU - Mikhailov, Vasily
AU - Parshin, Dmitriy
AU - Solovieva, Anna
AU - Lipina, Marina
AU - Lychagin, Alexey
AU - Timashev, Petr S.
AU - Svistunov, Andrey
AU - Fomin, Victor
AU - Shpichka, Anastasia
PY - 2022
DA - 2022/07/16
PB - Springer Nature
IS - 1
VL - 13
PMID - 35842689
SN - 1757-6512
ER -
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BibTex (up to 50 authors)
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@article{2022_Fayzullin,
author = {Alexey Fayzullin and Georgiy Vladimirov and Anastasia Kuryanova and Elvira Gafarova and Sergei Tkachev and Nastasia Kosheleva and Elena Istranova and Leonid Istranov and Yuri Efremov and Ivan Novikov and Polina Bikmulina and Kirill Puzakov and Pavel Petrov and Ivan Vyazankin and Andrey Nedorubov and Tatyana Khlebnikova and Valentina Kapustina and Pavel Trubnikov and Nikita Minaev and Aleksandr Kurkov and Valery Royuk and Vasily Mikhailov and Dmitriy Parshin and Anna Solovieva and Marina Lipina and Alexey Lychagin and Petr S. Timashev and Andrey Svistunov and Victor Fomin and Anastasia Shpichka},
title = {A defined road to tracheal reconstruction: laser structuring and cell support for rapid clinic translation},
journal = {Stem Cell Research and Therapy},
year = {2022},
volume = {13},
publisher = {Springer Nature},
month = {jul},
url = {https://stemcellres.biomedcentral.com/articles/10.1186/s13287-022-02997-8},
number = {1},
pages = {317},
doi = {10.1186/s13287-022-02997-8}
}