Open Access
BMC Genomics, volume 18, issue 1, publication number 492
The genome-wide transcription response to telomerase deficiency in the thermotolerant yeast Hansenula polymorpha DL-1
Beletsky Alexey V.
1
,
Malyavko Alexander N
2, 3
,
Sukhanova Maria V
4
,
Mardanova Eugenia S.
1
,
Zvereva Maria I.
2
,
Petrova Olga A
5
,
Parfenova Yulia Yu
2
,
Rubtsova Maria P
2
,
Mardanov Andrey V.
1
,
Lavrik Olga I.
4, 6
,
Dontsova Olga A.
2, 3, 5
,
Ravin Nikolai V.
1
Publication type: Journal Article
Publication date: 2017-06-28
PubMed ID:
28659185
Genetics
Biotechnology
Abstract
BackgroundIn the course of replication of eukaryotic chromosomes, the telomere length is maintained due to activity of telomerase, the ribonucleoprotein reverse transcriptase. Abolishing telomerase function causes progressive shortening of telomeres and, ultimately, cell cycle arrest and replicative senescence. To better understand the cellular response to telomerase deficiency, we performed a transcriptomic study for the thermotolerant methylotrophic yeast Hansenula polymorpha DL-1 lacking telomerase activity.ResultsMutant strain of H. polymorpha carrying a disrupted telomerase RNA gene was produced, grown to senescence and analyzed by RNA-seq along with wild type strain. Telomere shortening induced a transcriptional response involving genes relevant to telomere structure and maintenance, DNA damage response, information processing, and some metabolic pathways. Genes involved in DNA replication and repair, response to environmental stresses and intracellular traffic were up-regulated in senescent H. polymorpha cells, while strong down-regulation was observed for genes involved in transcription and translation, as well as core histones.ConclusionsComparison of the telomerase deletion transcription responses by Saccharomyces cerevisiae and H. polymorpha demonstrates that senescence makes different impact on the main metabolic pathways of these yeast species but induces similar changes in processes related to nucleic acids metabolism and protein synthesis. Up-regulation of a subunit of the TORC1 complex is clearly relevant for both types of yeast.
Citations by journals
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Scientific Reports
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Scientific Reports
1 publication, 50%
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Journal of Fungi
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Journal of Fungi
1 publication, 50%
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1
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Citations by publishers
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1
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Springer Nature
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Springer Nature
1 publication, 50%
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Multidisciplinary Digital Publishing Institute (MDPI)
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Multidisciplinary Digital Publishing Institute (MDPI)
1 publication, 50%
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1
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Beletsky A. V. et al. The genome-wide transcription response to telomerase deficiency in the thermotolerant yeast Hansenula polymorpha DL-1 // BMC Genomics. 2017. Vol. 18. No. 1. 492
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Beletsky A. V., Malyavko A. N., Sukhanova M. V., Mardanova E., Zvereva M. I., Petrova O. A., Parfenova Y. Yu., Rubtsova M. P., Mardanov A. V., Lavrik O., Dontsova O. A., Ravin N. V. The genome-wide transcription response to telomerase deficiency in the thermotolerant yeast Hansenula polymorpha DL-1 // BMC Genomics. 2017. Vol. 18. No. 1. 492
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TY - JOUR
DO - 10.1186/s12864-017-3889-x
UR - https://doi.org/10.1186%2Fs12864-017-3889-x
TI - The genome-wide transcription response to telomerase deficiency in the thermotolerant yeast Hansenula polymorpha DL-1
T2 - BMC Genomics
AU - Beletsky, Alexey V.
AU - Malyavko, Alexander N
AU - Sukhanova, Maria V
AU - Zvereva, Maria I.
AU - Petrova, Olga A
AU - Parfenova, Yulia Yu
AU - Rubtsova, Maria P
AU - Mardanov, Andrey V.
AU - Lavrik, Olga I.
AU - Dontsova, Olga A.
AU - Mardanova, Eugenia S.
AU - Ravin, Nikolai V.
PY - 2017
DA - 2017/06/28 00:00:00
PB - Springer Nature
IS - 1
VL - 18
PMID - 28659185
SN - 1471-2164
ER -
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@article{2017_Beletsky,
author = {Alexey V. Beletsky and Alexander N Malyavko and Maria V Sukhanova and Maria I. Zvereva and Olga A Petrova and Yulia Yu Parfenova and Maria P Rubtsova and Andrey V. Mardanov and Olga I. Lavrik and Olga A. Dontsova and Eugenia S. Mardanova and Nikolai V. Ravin},
title = {The genome-wide transcription response to telomerase deficiency in the thermotolerant yeast Hansenula polymorpha DL-1},
journal = {BMC Genomics},
year = {2017},
volume = {18},
publisher = {Springer Nature},
month = {jun},
url = {https://doi.org/10.1186%2Fs12864-017-3889-x},
number = {1},
doi = {10.1186/s12864-017-3889-x}
}