Open Access
Journal of Nanobiotechnology, volume 14, issue 1, publication number 67
Magnetocontrollability of Fe7 C3 @C superparamagnetic nanoparticles in living cells
Alieva Irina B
1
,
Kireev Igor
1, 2
,
Alyabyeva Natalia
3
,
Ruyter Antoine
3
,
Strelkova Olga S
1
,
Cherepaninets Varvara D
1
,
Majouga Alexander G.
4, 5
,
Davydov Valery A.
6
,
Khabashesku Valery N
7
,
Agafonov Viatcheslav
3, 5
,
Uzbekov Rustem
8, 9
3
GREMAN, UMR CNRS 7347, Université François Rabelais, Tours, France
|
7
Center for Technology Innovation, Baker Hughes Inc., Houston, USA
|
8
Laboratoire Biologie Cellulaire et Microscopie Electronique, Faculté de Médecine, Université François Rabelais, Tours, France
|
Publication type: Journal Article
Publication date: 2016-08-30
Journal:
Journal of Nanobiotechnology
Quartile SCImago
Q1
Quartile WOS
Q1
Impact factor: 10.2
ISSN: 14773155
PubMed ID:
27576904
Medicine (miscellaneous)
Pharmaceutical Science
Molecular Medicine
Applied Microbiology and Biotechnology
Bioengineering
Biomedical Engineering
Abstract
BackgroundA new type of superparamagnetic nanoparticles with chemical formula Fe7C3@C (MNPs) showed higher value of magnetization compared to traditionally used iron oxide-based nanoparticles as was shown in our previous studies. The in vitro biocompatibility tests demonstrated that the MNPs display high efficiency of cellular uptake and do not affect cyto-physiological parameters of cultured cells. These MNPs display effective magnetocontrollability in homogeneous liquids but their behavior in cytoplasm of living cells under the effect of magnetic field was not carefully analyzed yet.ResultsIn this work we investigated the magnetocontrollability of MNPs interacting with living cells in permanent magnetic field. It has been shown that cells were capable of capturing MNPs by upper part of the cell membrane, and from the surface of the cultivation substrate during motion process. Immunofluorescence studies using intracellular endosomal membrane marker showed that MNP agglomerates can be either located in endosomes or lying free in the cytoplasm. When attached cells were exposed to a magnetic field up to 0.15 T, the MNPs acquired magnetic moment and the displacement of incorporated MNP agglomerates in the direction of the magnet was observed. Weakly attached or non-attached cells, such as cells in mitosis or after cytoskeleton damaging treatments moved towards the magnet. During long time cultivation of cells with MNPs in a magnetic field gradual clearing of cells from MNPs was observed. It was the result of removing MNPs from the surface of the cell agglomerates discarded in the process of exocytosis.ConclusionsOur data allow us to conclude for the first time that the magnetic properties of the MNPs are sufficient for successful manipulation with MNP agglomerates both at the intracellular level, and within the whole cell. The structure of the outer shells of the MNPs allows firmly associate different types of biological molecules with them. This creates prospects for the use of such complexes for targeted delivery and selective removal of selected biological molecules from living cells.
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Citations by publishers
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- We do not take into account publications that without a DOI.
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- Statistics recalculated weekly.
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Alieva I. B. et al. Magnetocontrollability of Fe7C3@C superparamagnetic nanoparticles in living cells // Journal of Nanobiotechnology. 2016. Vol. 14. No. 1. 67
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Alieva I. B., Kireev I., Garanina A. S., Alyabyeva N., Ruyter A., Strelkova O. S., Zhironkina O. A., Cherepaninets V. D., Majouga A. G., Davydov V. A., Khabashesku V. N., Agafonov V., Uzbekov R. Magnetocontrollability of Fe7C3@C superparamagnetic nanoparticles in living cells // Journal of Nanobiotechnology. 2016. Vol. 14. No. 1. 67
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TY - JOUR
DO - 10.1186/s12951-016-0219-4
UR - https://doi.org/10.1186%2Fs12951-016-0219-4
TI - Magnetocontrollability of Fe7C3@C superparamagnetic nanoparticles in living cells
T2 - Journal of Nanobiotechnology
AU - Alyabyeva, Natalia
AU - Ruyter, Antoine
AU - Cherepaninets, Varvara D
AU - Agafonov, Viatcheslav
AU - Uzbekov, Rustem
AU - Alieva, Irina B
AU - Kireev, Igor
AU - Garanina, Anastasia S
AU - Strelkova, Olga S
AU - Zhironkina, Oxana A
AU - Davydov, Valery A.
AU - Khabashesku, Valery N
AU - Majouga, Alexander G.
PY - 2016
DA - 2016/08/30 00:00:00
PB - Springer Nature
IS - 1
VL - 14
PMID - 27576904
SN - 1477-3155
ER -
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@article{2016_Alieva,
author = {Natalia Alyabyeva and Antoine Ruyter and Varvara D Cherepaninets and Viatcheslav Agafonov and Rustem Uzbekov and Irina B Alieva and Igor Kireev and Anastasia S Garanina and Olga S Strelkova and Oxana A Zhironkina and Valery A. Davydov and Valery N Khabashesku and Alexander G. Majouga},
title = {Magnetocontrollability of Fe7C3@C superparamagnetic nanoparticles in living cells},
journal = {Journal of Nanobiotechnology},
year = {2016},
volume = {14},
publisher = {Springer Nature},
month = {aug},
url = {https://doi.org/10.1186%2Fs12951-016-0219-4},
number = {1},
doi = {10.1186/s12951-016-0219-4}
}