Open Access

Journal of Nanobiotechnology, volume 19, issue 1, publication number 354

Nanomedicine for increasing the oral bioavailability of cancer treatments

Parodi Alessandro ^{1, 2}

Buzaeva Polina ¹

Nigovora Daria ¹

Baldin Alexey ³

Kostyushev Dmitry ^{2, 4}

Chulanov Vladimir ^{2, 4, 5}

Savvateeva Lyudmila V. ¹

Zamyatnin Andrey A. ^{1, 2, 3, 6}

Hide authors affiliations Show authors affiliations: 6 affiliations

Institute of Molecular Medicine, Sechenov First Moscow State Medical University, Moscow, Russia |

Sirius University of Science and Technology, Sochi, Russia |

Belozersky Institute of Physico-chemical Biology, Lomonosov Moscow State University, Moscow, Russia |

⁴

National Medical Research Center of Tuberculosis and Infectious Diseases, Ministry of Health, Moscow, Russia |

⁵

Department of Infectious Diseases, Sechenov University, Moscow, Russia |

⁶

Faculty of Health and Medical Sciences, University of Surrey, Guildford, UK |

Publication type: Journal Article

Publication date: 2021-10-30

Springer Nature

Journal: Journal of Nanobiotechnology

Quartile SCImago

Quartile WOS

Impact factor: 10.2

ISSN: 14773155

DOI: 10.1186/s12951-021-01100-2

Copy DOI

PubMed ID: 34717658

Medicine (miscellaneous)

Pharmaceutical Science

Molecular Medicine

Applied Microbiology and Biotechnology

Bioengineering

Biomedical Engineering

Abstract

Oral administration is an appealing route of delivering cancer treatments. However, the gastrointestinal tract is characterized by specific and efficient physical, chemical, and biological barriers that decrease the bioavailability of medications, including chemotherapeutics. In recent decades, the fields of material science and nanomedicine have generated several delivery platforms with high potential for overcoming multiple barriers associated to oral administration. This review describes the properties of several nanodelivery systems that improve the bioavailability of orally administered therapeutics, highlighting their advantages and disadvantages in generating successful anticancer oral nanomedicines.

Graphical Abstract

By date By citations

Citations by journals

	1 2 3
International Journal of Molecular Sciences	International Journal of Molecular Sciences, 3, 7.69% International Journal of Molecular Sciences 3 publications, 7.69%
Pharmaceutics	Pharmaceutics, 2, 5.13% Pharmaceutics 2 publications, 5.13%
Journal of Nanobiotechnology	Journal of Nanobiotechnology, 2, 5.13% Journal of Nanobiotechnology 2 publications, 5.13%
Journal of Controlled Release	Journal of Controlled Release, 2, 5.13% Journal of Controlled Release 2 publications, 5.13%
International Journal of Biological Macromolecules	International Journal of Biological Macromolecules, 2, 5.13% International Journal of Biological Macromolecules 2 publications, 5.13%
International Journal of Nanomedicine	International Journal of Nanomedicine, 2, 5.13% International Journal of Nanomedicine 2 publications, 5.13%
Nanoscale Advances	Nanoscale Advances, 1, 2.56% Nanoscale Advances 1 publication, 2.56%
Materials	Materials, 1, 2.56% Materials 1 publication, 2.56%
Gels	Gels, 1, 2.56% Gels 1 publication, 2.56%
Polymers	Polymers, 1, 2.56% Polymers 1 publication, 2.56%
Frontiers in Bioengineering and Biotechnology	Frontiers in Bioengineering and Biotechnology, 1, 2.56% Frontiers in Bioengineering and Biotechnology 1 publication, 2.56%
Frontiers in Chemistry	Frontiers in Chemistry, 1, 2.56% Frontiers in Chemistry 1 publication, 2.56%
Frontiers in Cell and Developmental Biology	Frontiers in Cell and Developmental Biology, 1, 2.56% Frontiers in Cell and Developmental Biology 1 publication, 2.56%
Journal of Industrial and Engineering Chemistry	Journal of Industrial and Engineering Chemistry, 1, 2.56% Journal of Industrial and Engineering Chemistry 1 publication, 2.56%
Acta Pharmaceutica Sinica B	Acta Pharmaceutica Sinica B, 1, 2.56% Acta Pharmaceutica Sinica B 1 publication, 2.56%
Journal of Drug Delivery Science and Technology	Journal of Drug Delivery Science and Technology, 1, 2.56% Journal of Drug Delivery Science and Technology 1 publication, 2.56%
Biomedical Technology	Biomedical Technology, 1, 2.56% Biomedical Technology 1 publication, 2.56%
Advanced healthcare materials	Advanced healthcare materials, 1, 2.56% Advanced healthcare materials 1 publication, 2.56%
Wiley Interdisciplinary Reviews: Nanomedicine and Nanobiotechnology	Wiley Interdisciplinary Reviews: Nanomedicine and Nanobiotechnology, 1, 2.56% Wiley Interdisciplinary Reviews: Nanomedicine and Nanobiotechnology 1 publication, 2.56%
Cancers	Cancers, 1, 2.56% Cancers 1 publication, 2.56%
Expert Opinion on Drug Delivery	Expert Opinion on Drug Delivery, 1, 2.56% Expert Opinion on Drug Delivery 1 publication, 2.56%
Asian Journal of Pharmaceutical Sciences	Asian Journal of Pharmaceutical Sciences, 1, 2.56% Asian Journal of Pharmaceutical Sciences 1 publication, 2.56%
Medical Review	Medical Review, 1, 2.56% Medical Review 1 publication, 2.56%
Biomedicine and Pharmacotherapy	Biomedicine and Pharmacotherapy, 1, 2.56% Biomedicine and Pharmacotherapy 1 publication, 2.56%
Molecular Therapy - Nucleic Acids	Molecular Therapy - Nucleic Acids, 1, 2.56% Molecular Therapy - Nucleic Acids 1 publication, 2.56%
Toxicology Research	Toxicology Research, 1, 2.56% Toxicology Research 1 publication, 2.56%
Materials Advances	Materials Advances, 1, 2.56% Materials Advances 1 publication, 2.56%
Materials and Design	Materials and Design, 1, 2.56% Materials and Design 1 publication, 2.56%
Journal of Pharmaceutical Analysis	Journal of Pharmaceutical Analysis, 1, 2.56% Journal of Pharmaceutical Analysis 1 publication, 2.56%
	1 2 3

Citations by publishers

	2 4 6 8 10 12
Elsevier	Elsevier, 11, 28.21% Elsevier 11 publications, 28.21%
Multidisciplinary Digital Publishing Institute (MDPI)	Multidisciplinary Digital Publishing Institute (MDPI), 9, 23.08% Multidisciplinary Digital Publishing Institute (MDPI) 9 publications, 23.08%
Royal Society of Chemistry (RSC)	Royal Society of Chemistry (RSC), 3, 7.69% Royal Society of Chemistry (RSC) 3 publications, 7.69%
Frontiers Media S.A.	Frontiers Media S.A., 3, 7.69% Frontiers Media S.A. 3 publications, 7.69%
Wiley	Wiley, 3, 7.69% Wiley 3 publications, 7.69%
Springer Nature	Springer Nature, 2, 5.13% Springer Nature 2 publications, 5.13%
Dove Medical Press	Dove Medical Press, 2, 5.13% Dove Medical Press 2 publications, 5.13%
Korean Society of Industrial Engineering Chemistry	Korean Society of Industrial Engineering Chemistry, 1, 2.56% Korean Society of Industrial Engineering Chemistry 1 publication, 2.56%
Taylor & Francis	Taylor & Francis, 1, 2.56% Taylor & Francis 1 publication, 2.56%
Shenyang Pharmaceutical University	Shenyang Pharmaceutical University, 1, 2.56% Shenyang Pharmaceutical University 1 publication, 2.56%
Walter de Gruyter	Walter de Gruyter, 1, 2.56% Walter de Gruyter 1 publication, 2.56%
Xi'an Jiaotong University	Xi'an Jiaotong University, 1, 2.56% Xi'an Jiaotong University 1 publication, 2.56%
	2 4 6 8 10 12

We do not take into account publications that without a DOI.
Statistics recalculated only for publications connected to researchers, organizations and labs registered on the platform.
Statistics recalculated weekly.

{"yearsCitations":{"type":"bar","data":{"show":true,"labels":[2021,2022,2023,2024],"ids":[0,0,0,0],"codes":[0,0,0,0],"imageUrls":["","","",""],"datasets":[{"label":"Citations number","data":[1,11,21,6],"backgroundColor":["#3B82F6","#3B82F6","#3B82F6","#3B82F6"],"percentage":["2.56","28.21","53.85","15.38"],"barThickness":null}]},"options":{"indexAxis":"x","maintainAspectRatio":true,"scales":{"y":{"ticks":{"precision":0,"autoSkip":false,"font":{"family":"Montserrat"},"color":"#000000"}},"x":{"ticks":{"stepSize":1,"precision":0,"font":{"family":"Montserrat"},"color":"#000000"}}},"plugins":{"legend":{"position":"top","labels":{"font":{"family":"Montserrat"},"color":"#000000"}},"title":{"display":true,"text":"Citations per year","font":{"size":24,"family":"Montserrat","weight":600},"color":"#000000"}}}},"journals":{"type":"bar","data":{"show":true,"labels":["International Journal of Molecular Sciences","Pharmaceutics","Journal of Nanobiotechnology","Journal of Controlled Release","International Journal of Biological Macromolecules","International Journal of Nanomedicine","Nanoscale Advances","Materials","Gels","Polymers","Frontiers in Bioengineering and Biotechnology","Frontiers in Chemistry","Frontiers in Cell and Developmental Biology","Journal of Industrial and Engineering Chemistry","Acta Pharmaceutica Sinica B","Journal of Drug Delivery Science and Technology","Biomedical Technology","Advanced healthcare materials","Wiley Interdisciplinary Reviews: Nanomedicine and Nanobiotechnology","Cancers","Expert Opinion on Drug Delivery","Asian Journal of Pharmaceutical Sciences","Medical Review","Biomedicine and Pharmacotherapy","Molecular Therapy - Nucleic Acids","Toxicology Research","Materials Advances","Materials and Design","Journal of Pharmaceutical Analysis"],"ids":[14627,4502,11794,14351,23035,10956,16663,25198,16915,11204,13389,6407,12128,1786,11233,17907,35942,21975,21055,22471,10591,21693,35918,23951,20403,711,25900,8941,8485],"codes":[0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0],"imageUrls":["\/storage\/images\/resized\/MjH1ITP7lMYGxeqUZfkt2BnVLgjkk413jwBV97XX_medium.webp","\/storage\/images\/resized\/MjH1ITP7lMYGxeqUZfkt2BnVLgjkk413jwBV97XX_medium.webp","\/storage\/images\/resized\/voXLqlsvTwv5p3iMQ8Dhs95nqB4AXOG7Taj7G4ra_medium.webp","\/storage\/images\/resized\/GDnYOu1UpMMfMMRV6Aqle4H0YLLsraeD9IP9qScG_medium.webp","\/storage\/images\/resized\/GDnYOu1UpMMfMMRV6Aqle4H0YLLsraeD9IP9qScG_medium.webp","\/storage\/images\/resized\/wVWp6zaxUsMdR03dYMdOZoesUrVGtNMWkHKByIvT_medium.webp","\/storage\/images\/resized\/leiAYcRDGTSl5B1eCnwpSGqmDEUEfDPPoYisFGhT_medium.webp","\/storage\/images\/resized\/MjH1ITP7lMYGxeqUZfkt2BnVLgjkk413jwBV97XX_medium.webp","\/storage\/images\/resized\/MjH1ITP7lMYGxeqUZfkt2BnVLgjkk413jwBV97XX_medium.webp","\/storage\/images\/resized\/MjH1ITP7lMYGxeqUZfkt2BnVLgjkk413jwBV97XX_medium.webp","\/storage\/images\/resized\/4QWA67eqfcfyOiA8Wk7YnqroHFqQbTsmDJUYTCTg_medium.webp","\/storage\/images\/resized\/4QWA67eqfcfyOiA8Wk7YnqroHFqQbTsmDJUYTCTg_medium.webp","\/storage\/images\/resized\/4QWA67eqfcfyOiA8Wk7YnqroHFqQbTsmDJUYTCTg_medium.webp","","\/storage\/images\/resized\/GDnYOu1UpMMfMMRV6Aqle4H0YLLsraeD9IP9qScG_medium.webp","\/storage\/images\/resized\/GDnYOu1UpMMfMMRV6Aqle4H0YLLsraeD9IP9qScG_medium.webp","\/storage\/images\/resized\/GDnYOu1UpMMfMMRV6Aqle4H0YLLsraeD9IP9qScG_medium.webp","\/storage\/images\/resized\/bRyGpdm98BkAUYiK1YFNpl5Z7hPu6Gd87gbIeuG3_medium.webp","\/storage\/images\/resized\/bRyGpdm98BkAUYiK1YFNpl5Z7hPu6Gd87gbIeuG3_medium.webp","\/storage\/images\/resized\/MjH1ITP7lMYGxeqUZfkt2BnVLgjkk413jwBV97XX_medium.webp","\/storage\/images\/resized\/5YZtvLvkPZuc2JHOaZsjCvGSHFCuC3drUwN3YAc5_medium.webp","","\/storage\/images\/resized\/3SpVxcYL33bOvPq4sHxJLH2NeKNeDloahSUpNiO4_medium.webp","\/storage\/images\/resized\/GDnYOu1UpMMfMMRV6Aqle4H0YLLsraeD9IP9qScG_medium.webp","\/storage\/images\/resized\/GDnYOu1UpMMfMMRV6Aqle4H0YLLsraeD9IP9qScG_medium.webp","\/storage\/images\/resized\/leiAYcRDGTSl5B1eCnwpSGqmDEUEfDPPoYisFGhT_medium.webp","\/storage\/images\/resized\/leiAYcRDGTSl5B1eCnwpSGqmDEUEfDPPoYisFGhT_medium.webp","\/storage\/images\/resized\/GDnYOu1UpMMfMMRV6Aqle4H0YLLsraeD9IP9qScG_medium.webp",""],"datasets":[{"label":"","data":[3,2,2,2,2,2,1,1,1,1,1,1,1,1,1,1,1,1,1,1,1,1,1,1,1,1,1,1,1],"backgroundColor":["#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6"],"percentage":[7.69,5.13,5.13,5.13,5.13,5.13,2.56,2.56,2.56,2.56,2.56,2.56,2.56,2.56,2.56,2.56,2.56,2.56,2.56,2.56,2.56,2.56,2.56,2.56,2.56,2.56,2.56,2.56,2.56],"barThickness":13}]},"options":{"indexAxis":"y","maintainAspectRatio":false,"scales":{"y":{"ticks":{"precision":0,"autoSkip":false,"font":{"family":"Montserrat"},"color":"#000000"}},"x":{"ticks":{"stepSize":null,"precision":0,"font":{"family":"Montserrat"},"color":"#000000"}}},"plugins":{"legend":{"position":"top","labels":{"font":{"family":"Montserrat"},"color":"#000000"}},"title":{"display":true,"text":"Journals","font":{"size":24,"family":"Montserrat","weight":600},"color":"#000000"}}}},"publishers":{"type":"bar","data":{"show":true,"labels":["Elsevier","Multidisciplinary Digital Publishing Institute (MDPI)","Royal Society of Chemistry (RSC)","Frontiers Media S.A.","Wiley","Springer Nature","Dove Medical Press","Korean Society of Industrial Engineering Chemistry","Taylor & Francis","Shenyang Pharmaceutical University","Walter de Gruyter","Xi'an Jiaotong University"],"ids":[17,202,123,208,11,8,417,709,18,6085,4,2777],"codes":[0,0,0,0,0,0,0,0,0,0,0,0],"imageUrls":["\/storage\/images\/resized\/GDnYOu1UpMMfMMRV6Aqle4H0YLLsraeD9IP9qScG_medium.webp","\/storage\/images\/resized\/MjH1ITP7lMYGxeqUZfkt2BnVLgjkk413jwBV97XX_medium.webp","\/storage\/images\/resized\/leiAYcRDGTSl5B1eCnwpSGqmDEUEfDPPoYisFGhT_medium.webp","\/storage\/images\/resized\/4QWA67eqfcfyOiA8Wk7YnqroHFqQbTsmDJUYTCTg_medium.webp","\/storage\/images\/resized\/bRyGpdm98BkAUYiK1YFNpl5Z7hPu6Gd87gbIeuG3_medium.webp","\/storage\/images\/resized\/voXLqlsvTwv5p3iMQ8Dhs95nqB4AXOG7Taj7G4ra_medium.webp","\/storage\/images\/resized\/wVWp6zaxUsMdR03dYMdOZoesUrVGtNMWkHKByIvT_medium.webp","","\/storage\/images\/resized\/5YZtvLvkPZuc2JHOaZsjCvGSHFCuC3drUwN3YAc5_medium.webp","","\/storage\/images\/resized\/3SpVxcYL33bOvPq4sHxJLH2NeKNeDloahSUpNiO4_medium.webp",""],"datasets":[{"label":"","data":[11,9,3,3,3,2,2,1,1,1,1,1],"backgroundColor":["#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6"],"percentage":[28.21,23.08,7.69,7.69,7.69,5.13,5.13,2.56,2.56,2.56,2.56,2.56],"barThickness":13}]},"options":{"indexAxis":"y","maintainAspectRatio":false,"scales":{"y":{"ticks":{"precision":0,"autoSkip":false,"font":{"family":"Montserrat"},"color":"#000000"}},"x":{"ticks":{"stepSize":null,"precision":0,"font":{"family":"Montserrat"},"color":"#000000"}}},"plugins":{"legend":{"position":"top","labels":{"font":{"family":"Montserrat"},"color":"#000000"}},"title":{"display":true,"text":"Publishers","font":{"size":24,"family":"Montserrat","weight":600},"color":"#000000"}}}}}

Publication PDF

Metrics

Cite this

GOST |

Cite this

GOST Copy

Parodi A. et al. Nanomedicine for increasing the oral bioavailability of cancer treatments // Journal of Nanobiotechnology. 2021. Vol. 19. No. 1. 354

GOST all authors (up to 50) Copy

Parodi A., Buzaeva P., Nigovora D., Baldin A., Kostyushev D., Chulanov V., Savvateeva L. V., Zamyatnin A. A. Nanomedicine for increasing the oral bioavailability of cancer treatments // Journal of Nanobiotechnology. 2021. Vol. 19. No. 1. 354

RIS |

Cite this

RIS Copy

TY - JOUR

DO - 10.1186/s12951-021-01100-2

UR - https://doi.org/10.1186%2Fs12951-021-01100-2

TI - Nanomedicine for increasing the oral bioavailability of cancer treatments

T2 - Journal of Nanobiotechnology

AU - Buzaeva, Polina

AU - Nigovora, Daria

AU - Kostyushev, Dmitry

AU - Chulanov, Vladimir

AU - Savvateeva, Lyudmila V.

AU - Parodi, Alessandro

AU - Baldin, Alexey

AU - Zamyatnin, Andrey A.

PY - 2021

DA - 2021/10/30 00:00:00

PB - Springer Nature

IS - 1

VL - 19

PMID - 34717658

SN - 1477-3155

ER -

BibTex

Cite this

BibTex Copy

@article{2021_Parodi,

author = {Polina Buzaeva and Daria Nigovora and Dmitry Kostyushev and Vladimir Chulanov and Lyudmila V. Savvateeva and Alessandro Parodi and Alexey Baldin and Andrey A. Zamyatnin},

title = {Nanomedicine for increasing the oral bioavailability of cancer treatments},

journal = {Journal of Nanobiotechnology},

year = {2021},

volume = {19},

publisher = {Springer Nature},

month = {oct},

url = {https://doi.org/10.1186%2Fs12951-021-01100-2},

number = {1},

doi = {10.1186/s12951-021-01100-2}

}

Found error?

Publisher

Springer Nature

Journal

Journal of Nanobiotechnology

Quartile SCImago

Quartile WOS

Impact factor

10.2

ISSN

14773155 (Print)

Labs

Laboratory of Genetic Technologies

Profiles

Kostyushev, Dmitry S