Open Access
Open access
Ovid Technologies (Wolters Kluwer Health)
Neurosurgery

Surgical Adverse Events for Primary Tumors of the Spine and Their Impact on Outcomes: An Observational Study From the Primary Tumors Research and Outcomes Network

Mathieu Laflamme 1
, 
Alessandro Gasbarrini 2, 3, 4
, 
Laurence D. Rhines 3, 5
, 
Aron Lazary 6
, 
Ziya L. Gokaslan 7
, 
Jeremy J. Reynolds 8
, 
Alessandro Luzzati 9
, 
Alexander C. Disch 10
, 
Dean Chou 11
, 
Michelle J. Clarke 12
, 
Wei Feng 13
, 
Chetan Bettegowda 14
, 
Y. Raja Rampersaud 15
, 
Stefano Boriani 9
, 
John H. Shin 16
, 
Elizabeth Lord 17
, 
Daniel M. Sciubba 18
, 
Ilya Laufer 19
, 
Arjun Sahgal 20
, 
Charles G. Fisher 21
, 
Nicolas Dea 21
1
 
2
 
3
 
4
 
5
 
6
 
National Center for Spinal Disorders, Buda Health Center, Budapest, Hungary; | 
7
 
8
 
9
 
10
 
11
 
12
 
13
 
14
 
15
 
16
 
17
 
18
 
Department of Neurosurgery, Zucker School of Medicine at Hofstra/Northwell, Long Island Jewish Medical Center and North Shore University Hospital, Northwell Health, Manhasset, New York, USA; | 
19
 
20
 
21
 
Publication type: Journal Article
Publication date: 2025-02-05
Ovid Technologies (Wolters Kluwer Health)
scimago Q1
wos Q1
SJR: 1.249
CiteScore: 6.9
Impact factor: 3.9
ISSN: 0148396X, 15244040
Abstract
BACKGROUND AND OBJECTIVES:

Aggressive resection for primary tumors of the spine are associated with a high rate of adverse events (AEs), but the impact of AEs on patient-reported outcomes (PROs) remains unknown and is critical to the shared decision-making. Our primary objective was to assess the impact of surgical AEs on PROs using an international registry. Assessing the impact on clinical outcomes and identifying risk factors for AEs were our secondary objectives.

METHODS:

Patients who underwent surgery for a primary spinal tumor were selected through the Primary Tumor Research and Outcomes Network. Our primary outcome was the impact of AEs on PROs at 3 and 12 months after surgery (measured with Spinal Oncology Study Group Outcomes Questionnaire, Short-Form 36, and EuroQol 5 Dimension). We also assessed the impact on clinical outcomes (local control, surgical margins, readmission, reoperation, and mortality). We stratified our results according to severity of AEs, histology, and type of resection.

RESULTS:

374 patients met inclusion criteria (219 males/155 females). The mean age of the cohort was 48.7 years. The most frequent histology was chordoma (37.3%) followed by chondrosarcoma (8.8%). Sixty-seven patients (17.9%) experienced at least 1 intraoperative AE and 117 patients (31.3%) had at least 1 postoperative AE within 3 months. Overall, 159 patients (42.5%) experienced AEs. The readmission rate was significantly higher in patients who experienced AEs (Any AE: 10.1% vs no AE: 1.9% within 3 months; P = <0.001). PROs were not significantly affected by AEs in most questionnaires. Local control, risk of reoperation, mortality, and achieving preplanned margins were similar between AE groups.

CONCLUSION:

The rate of surgical AEs is considerable in this population. Surgical AEs seem to be associated with a higher number of readmissions, but do not seem to result in significant differences in PROs or in a higher risk of reoperation, mortality, and failure to achieve preplanned margins.

Found 
Found 

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GOST Copy
Laflamme M. et al. Surgical Adverse Events for Primary Tumors of the Spine and Their Impact on Outcomes: An Observational Study From the Primary Tumors Research and Outcomes Network // Neurosurgery. 2025.
GOST all authors (up to 50) Copy
Laflamme M., Gasbarrini A., Rhines L. D., Lazary A., Gokaslan Z. L., Reynolds J. J., Luzzati A., Disch A. C., Chou D., Clarke M. J., Wei Feng, Bettegowda C., Rampersaud Y. R., Boriani S., Shin J. H., Lord E., Sciubba D. M., Laufer I., Sahgal A., Fisher C. G., Dea N. Surgical Adverse Events for Primary Tumors of the Spine and Their Impact on Outcomes: An Observational Study From the Primary Tumors Research and Outcomes Network // Neurosurgery. 2025.
RIS |
Cite this
RIS Copy
TY - JOUR
DO - 10.1227/neu.0000000000003369
UR - https://journals.lww.com/10.1227/neu.0000000000003369
TI - Surgical Adverse Events for Primary Tumors of the Spine and Their Impact on Outcomes: An Observational Study From the Primary Tumors Research and Outcomes Network
T2 - Neurosurgery
AU - Laflamme, Mathieu
AU - Gasbarrini, Alessandro
AU - Rhines, Laurence D.
AU - Lazary, Aron
AU - Gokaslan, Ziya L.
AU - Reynolds, Jeremy J.
AU - Luzzati, Alessandro
AU - Disch, Alexander C.
AU - Chou, Dean
AU - Clarke, Michelle J.
AU - Wei Feng
AU - Bettegowda, Chetan
AU - Rampersaud, Y. Raja
AU - Boriani, Stefano
AU - Shin, John H.
AU - Lord, Elizabeth
AU - Sciubba, Daniel M.
AU - Laufer, Ilya
AU - Sahgal, Arjun
AU - Fisher, Charles G.
AU - Dea, Nicolas
PY - 2025
DA - 2025/02/05
PB - Ovid Technologies (Wolters Kluwer Health)
SN - 0148-396X
SN - 1524-4040
ER -
BibTex
Cite this
BibTex (up to 50 authors) Copy
@article{2025_Laflamme,
author = {Mathieu Laflamme and Alessandro Gasbarrini and Laurence D. Rhines and Aron Lazary and Ziya L. Gokaslan and Jeremy J. Reynolds and Alessandro Luzzati and Alexander C. Disch and Dean Chou and Michelle J. Clarke and Wei Feng and Chetan Bettegowda and Y. Raja Rampersaud and Stefano Boriani and John H. Shin and Elizabeth Lord and Daniel M. Sciubba and Ilya Laufer and Arjun Sahgal and Charles G. Fisher and Nicolas Dea},
title = {Surgical Adverse Events for Primary Tumors of the Spine and Their Impact on Outcomes: An Observational Study From the Primary Tumors Research and Outcomes Network},
journal = {Neurosurgery},
year = {2025},
publisher = {Ovid Technologies (Wolters Kluwer Health)},
month = {feb},
url = {https://journals.lww.com/10.1227/neu.0000000000003369},
doi = {10.1227/neu.0000000000003369}
}