Biological and Pharmaceutical Bulletin, volume 28, issue 9, pages 1798-1800

7-Hydroxy-3-(4-hydroxybenzyl)chroman and Broussonin B: Neurotrophic Compounds, Isolated from Anemarrhena asphodeloides BUNGE, Function as Proteasome Inhibitors

Sachiko TSUKAMOTO 1
, 
Takeshi Wakana 1
, 
Keiichirou Koimaru 1
, 
Takushi Yoshida 1
, 
Mako Sato 1
, 
Tomihisa Ohta 1
1
 
Publication type: Journal Article
Publication date: 2005-09-01
scimago Q2
wos Q3
SJR: 0.518
CiteScore: 3.5
Impact factor: 1.7
ISSN: 09186158, 13475215
DOI:  10.1248/bpb.28.1798
PubMed ID:  16141565
General Medicine
Pharmacology
Pharmaceutical Science
Abstract
The extract of Anemarrhenae Rhizoma (rhizomes of Anemarrhena asphodeloides BUNGE) showed neurotrophic activity toward rat pheochromocytoma (PC-12) cells. Bioassay-guided purification afforded four compounds, 2,6,4'-trihydroxy-4-methoxybenzophenone (1), 7-hydroxy-3-(4-hydroxybenzyl)chroman (2), broussonin B (3), and cis-hinokiresinol (4). Compounds 1-3 induced neurite outgrowth in PC-12 cells at concentration of 50 microg/ml, while 4 was less active. In addition, compounds 2-4 showed moderate inhibitory activities against a chymotrypsin-like activity of the proteasome.
Found 
Found 

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