Effects of Gentianine on the Production of Pro-inflammatory Cytokines in Male Sprague-Dawley Rats Treated with Lipopolysaccharide (LPS)
Тип публикации: Journal Article
Дата публикации: 2005-04-01
scimago Q2
wos Q3
БС2
SJR: 0.541
CiteScore: 3
Impact factor: 1.7
ISSN: 09186158, 13475215
PubMed ID:
15802824
General Medicine
Pharmacology
Pharmaceutical Science
Краткое описание
This study was undertaken to elucidate the mechanism of anti-inflammatory action of gentianine, a constituent of Gentiana Macrophylla. The effects of gentianine on lipopolysacharide (LPS)-induced production of pro-inflammatory cytokines were investigated in male Sprague-Dawley rats. For the first time, we found that oral administration of gentianine (10-100 mg/kg) suppressed the increases in tumor necrosis factor-alpha (TNF-alpha) (ED(50), 37.7 mg/kg) and interleukin (IL)-6 (ED(50), 38.5 mg/kg) in the sera from the rats challenged with bacterial LPS (100 microg/kg; i.p.). However, LPS induced production of other interleukins, such as IL-alpha, was not significantly altered by gentianine. These results suggest that the potential anti-inflammatory action of gentianine might be at least partly based on the suppressed production of TNF-alpha and IL-6.
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Kwak W. et al. Effects of Gentianine on the Production of Pro-inflammatory Cytokines in Male Sprague-Dawley Rats Treated with Lipopolysaccharide (LPS) // Biological and Pharmaceutical Bulletin. 2005. Vol. 28. No. 4. pp. 750-753.
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Kwak W., Kim J., Ryu K. H., Cho Y. K., Jeon S. K., Moon C. H. Effects of Gentianine on the Production of Pro-inflammatory Cytokines in Male Sprague-Dawley Rats Treated with Lipopolysaccharide (LPS) // Biological and Pharmaceutical Bulletin. 2005. Vol. 28. No. 4. pp. 750-753.
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TY - JOUR
DO - 10.1248/bpb.28.750
UR - https://doi.org/10.1248/bpb.28.750
TI - Effects of Gentianine on the Production of Pro-inflammatory Cytokines in Male Sprague-Dawley Rats Treated with Lipopolysaccharide (LPS)
T2 - Biological and Pharmaceutical Bulletin
AU - Kwak, Wie-Jong
AU - Kim, Joo-Hyon
AU - Ryu, Keun Ho
AU - Cho, Yong Kuk
AU - Jeon, Sun Kyung
AU - Moon, Chang Ho
PY - 2005
DA - 2005/04/01
PB - Pharmaceutical Society of Japan
SP - 750-753
IS - 4
VL - 28
PMID - 15802824
SN - 0918-6158
SN - 1347-5215
ER -
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@article{2005_Kwak,
author = {Wie-Jong Kwak and Joo-Hyon Kim and Keun Ho Ryu and Yong Kuk Cho and Sun Kyung Jeon and Chang Ho Moon},
title = {Effects of Gentianine on the Production of Pro-inflammatory Cytokines in Male Sprague-Dawley Rats Treated with Lipopolysaccharide (LPS)},
journal = {Biological and Pharmaceutical Bulletin},
year = {2005},
volume = {28},
publisher = {Pharmaceutical Society of Japan},
month = {apr},
url = {https://doi.org/10.1248/bpb.28.750},
number = {4},
pages = {750--753},
doi = {10.1248/bpb.28.750}
}
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MLA
Скопировать
Kwak, Wie-Jong, et al. “Effects of Gentianine on the Production of Pro-inflammatory Cytokines in Male Sprague-Dawley Rats Treated with Lipopolysaccharide (LPS).” Biological and Pharmaceutical Bulletin, vol. 28, no. 4, Apr. 2005, pp. 750-753. https://doi.org/10.1248/bpb.28.750.