Open Access
Crystal Structure of the Neisseria gonorrhoeae MtrD Inner Membrane Multidrug Efflux Pump
Jani Reddy Bolla
1
,
Chih-Chia Su
2
,
Sylvia V. Do
3
,
Abhijith Radhakrishnan
1
,
Nitin Kumar
1
,
Feng Long
2
,
Tsung Han Chou
2
,
Jared A Delmar
2
,
Hsiang-Ting Lei
1
,
Kanagalaghatta R. Rajashankar
4
,
William M. Shafer
5
,
Edward W. Yu
6
2
4
Publication type: Journal Article
Publication date: 2014-06-05
scimago Q1
wos Q2
SJR: 0.803
CiteScore: 5.4
Impact factor: 2.6
ISSN: 19326203
PubMed ID:
24901477
Multidisciplinary
Abstract
Neisseria gonorrhoeae is an obligate human pathogen and the causative agent of the sexually-transmitted disease gonorrhea. The control of this disease has been compromised by the increasing proportion of infections due to antibiotic-resistant strains, which are growing at an alarming rate. The MtrCDE tripartite multidrug efflux pump, belonging to the hydrophobic and amphiphilic efflux resistance-nodulation-cell division (HAE-RND) family, spans both the inner and outer membranes of N. gonorrhoeae and confers resistance to a variety of antibiotics and toxic compounds. We here report the crystal structure of the inner membrane MtrD multidrug efflux pump, which reveals a novel structural feature that is not found in other RND efflux pumps.
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69
Total citations:
69
Citations from 2024:
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(10.15%)
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GOST
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Bolla J. R. et al. Crystal Structure of the Neisseria gonorrhoeae MtrD Inner Membrane Multidrug Efflux Pump // PLoS ONE. 2014. Vol. 9. No. 6. p. e97903.
GOST all authors (up to 50)
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Bolla J. R., Su C., Do S. V., Radhakrishnan A., Kumar N., Long F., Chou T. H., Delmar J. A., Lei H., Rajashankar K. R., Shafer W. M., Yu E. W. Crystal Structure of the Neisseria gonorrhoeae MtrD Inner Membrane Multidrug Efflux Pump // PLoS ONE. 2014. Vol. 9. No. 6. p. e97903.
Cite this
RIS
Copy
TY - JOUR
DO - 10.1371/journal.pone.0097903
UR - https://doi.org/10.1371/journal.pone.0097903
TI - Crystal Structure of the Neisseria gonorrhoeae MtrD Inner Membrane Multidrug Efflux Pump
T2 - PLoS ONE
AU - Bolla, Jani Reddy
AU - Su, Chih-Chia
AU - Do, Sylvia V.
AU - Radhakrishnan, Abhijith
AU - Kumar, Nitin
AU - Long, Feng
AU - Chou, Tsung Han
AU - Delmar, Jared A
AU - Lei, Hsiang-Ting
AU - Rajashankar, Kanagalaghatta R.
AU - Shafer, William M.
AU - Yu, Edward W.
PY - 2014
DA - 2014/06/05
PB - Public Library of Science (PLoS)
SP - e97903
IS - 6
VL - 9
PMID - 24901477
SN - 1932-6203
ER -
Cite this
BibTex (up to 50 authors)
Copy
@article{2014_Bolla,
author = {Jani Reddy Bolla and Chih-Chia Su and Sylvia V. Do and Abhijith Radhakrishnan and Nitin Kumar and Feng Long and Tsung Han Chou and Jared A Delmar and Hsiang-Ting Lei and Kanagalaghatta R. Rajashankar and William M. Shafer and Edward W. Yu},
title = {Crystal Structure of the Neisseria gonorrhoeae MtrD Inner Membrane Multidrug Efflux Pump},
journal = {PLoS ONE},
year = {2014},
volume = {9},
publisher = {Public Library of Science (PLoS)},
month = {jun},
url = {https://doi.org/10.1371/journal.pone.0097903},
number = {6},
pages = {e97903},
doi = {10.1371/journal.pone.0097903}
}
Cite this
MLA
Copy
Bolla, Jani Reddy, et al. “Crystal Structure of the Neisseria gonorrhoeae MtrD Inner Membrane Multidrug Efflux Pump.” PLoS ONE, vol. 9, no. 6, Jun. 2014, p. e97903. https://doi.org/10.1371/journal.pone.0097903.