Open Access
Open access
Public Library of Science (PLoS)
PLoS ONE
,  volume 17 ,  issue 4 April ,  pages e0266386

Prevalence of uncoupling protein one genetic polymorphisms and their relationship with cardiovascular and metabolic health

Petros C. Dinas 1
, 
Eleni Nintou 2
, 
Maria Vliora 2
, 
Anna E Pravednikova 3
, 
Paraskevi Sakellariou 2
, 
Agata Witkowicz 4
, 
Zaur M. Kachaev 5
, 
Victor V Kerchev 3
, 
Svetlana N Larina 3
, 
James Cotton 6
, 
Anna Kowalska 7
, 
Paraskevi Gkiata 2
, 
Alexandra Bargiota 8
, 
Zaruhi A Khachatryan 9
, 
Anahit A Hovhannisyan 9
, 
Mariya A Antonosyan 9
, 
Sona Margaryan 9
, 
Anna Partyka 4
, 
Pawel Bogdanski 10
, 
Monika Szulinska 10
, 
Matylda Kregielska-Narozna 10
, 
Rafał Czepczyński 11
, 
Marek Ruchała 11
, 
Anna Tomkiewicz 4
, 
LEVON YEPISKOPOSYAN 12
, 
Lidia Karabon 4
, 
Y. V. Shidlovskii 3
, 
George S. Metsios 13
, 
Andreas D Flouris 2
1
 
2
 
3
 
4
 
5
 
6
 
Royal Wolverhampton NHS Trust, New Cross Hospital, Wolverhampton, United Kingdom | 
7
 
8
 
9
 
10
 
11
 
12
 
13
 
Publication type: Journal Article
Publication date: 2022-04-28
Public Library of Science (PLoS)
scimago Q1
wos Q2
SJR: 0.803
CiteScore: 5.4
Impact factor: 2.6
ISSN: 19326203
Multidisciplinary
Abstract

Contribution of UCP1 single nucleotide polymorphisms (SNPs) to susceptibility for cardiometabolic pathologies (CMP) and their involvement in specific risk factors for these conditions varies across populations. We tested whether UCP1 SNPs A-3826G, A-1766G, Ala64Thr and A-112C are associated with common CMP and their risk factors across Armenia, Greece, Poland, Russia and United Kingdom. This case-control study included genotyping of these SNPs, from 2,283 Caucasians. Results were extended via systematic review and meta-analysis. In Armenia, GA genotype and A allele of Ala64Thr displayed ~2-fold higher risk for CMP compared to GG genotype and G allele, respectively (p<0.05). In Greece, A allele of Ala64Thr decreased risk of CMP by 39%. Healthy individuals with A-3826G GG genotype and carriers of mutant allele of A-112C and Ala64Thr had higher body mass index compared to those carrying other alleles. In healthy Polish, higher waist-to-hip ratio (WHR) was observed in heterozygotes A-3826G compared to AA homozygotes. Heterozygosity of A-112C and Ala64Thr SNPs was related to lower WHR in CMP individuals compared to wild type homozygotes (p<0.05). Meta-analysis showed no statistically significant odds-ratios across our SNPs (p>0.05). Concluding, the studied SNPs could be associated with the most common CMP and their risk factors in some populations.

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Dinas P. C. et al. Prevalence of uncoupling protein one genetic polymorphisms and their relationship with cardiovascular and metabolic health // PLoS ONE. 2022. Vol. 17. No. 4 April. p. e0266386.
GOST all authors (up to 50) Copy
Dinas P. C., Nintou E., Vliora M., Pravednikova A. E., Sakellariou P., Witkowicz A., Kachaev Z. M., Kerchev V. V., Larina S. N., Cotton J., Kowalska A., Gkiata P., Bargiota A., Khachatryan Z. A., Hovhannisyan A. A., Antonosyan M. A., Margaryan S., Partyka A., Bogdanski P., Szulinska M., Kregielska-Narozna M., Czepczyński R., Ruchała M., Tomkiewicz A., YEPISKOPOSYAN L., Karabon L., Shidlovskii Y. V., Metsios G. S., Flouris A. D. Prevalence of uncoupling protein one genetic polymorphisms and their relationship with cardiovascular and metabolic health // PLoS ONE. 2022. Vol. 17. No. 4 April. p. e0266386.
RIS |
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RIS Copy
TY - JOUR
DO - 10.1371/journal.pone.0266386
UR - https://doi.org/10.1371/journal.pone.0266386
TI - Prevalence of uncoupling protein one genetic polymorphisms and their relationship with cardiovascular and metabolic health
T2 - PLoS ONE
AU - Dinas, Petros C.
AU - Nintou, Eleni
AU - Vliora, Maria
AU - Pravednikova, Anna E
AU - Sakellariou, Paraskevi
AU - Witkowicz, Agata
AU - Kachaev, Zaur M.
AU - Kerchev, Victor V
AU - Larina, Svetlana N
AU - Cotton, James
AU - Kowalska, Anna
AU - Gkiata, Paraskevi
AU - Bargiota, Alexandra
AU - Khachatryan, Zaruhi A
AU - Hovhannisyan, Anahit A
AU - Antonosyan, Mariya A
AU - Margaryan, Sona
AU - Partyka, Anna
AU - Bogdanski, Pawel
AU - Szulinska, Monika
AU - Kregielska-Narozna, Matylda
AU - Czepczyński, Rafał
AU - Ruchała, Marek
AU - Tomkiewicz, Anna
AU - YEPISKOPOSYAN, LEVON
AU - Karabon, Lidia
AU - Shidlovskii, Y. V.
AU - Metsios, George S.
AU - Flouris, Andreas D
PY - 2022
DA - 2022/04/28
PB - Public Library of Science (PLoS)
SP - e0266386
IS - 4 April
VL - 17
PMID - 35482655
SN - 1932-6203
ER -
BibTex |
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BibTex (up to 50 authors) Copy
@article{2022_Dinas,
author = {Petros C. Dinas and Eleni Nintou and Maria Vliora and Anna E Pravednikova and Paraskevi Sakellariou and Agata Witkowicz and Zaur M. Kachaev and Victor V Kerchev and Svetlana N Larina and James Cotton and Anna Kowalska and Paraskevi Gkiata and Alexandra Bargiota and Zaruhi A Khachatryan and Anahit A Hovhannisyan and Mariya A Antonosyan and Sona Margaryan and Anna Partyka and Pawel Bogdanski and Monika Szulinska and Matylda Kregielska-Narozna and Rafał Czepczyński and Marek Ruchała and Anna Tomkiewicz and LEVON YEPISKOPOSYAN and Lidia Karabon and Y. V. Shidlovskii and George S. Metsios and Andreas D Flouris},
title = {Prevalence of uncoupling protein one genetic polymorphisms and their relationship with cardiovascular and metabolic health},
journal = {PLoS ONE},
year = {2022},
volume = {17},
publisher = {Public Library of Science (PLoS)},
month = {apr},
url = {https://doi.org/10.1371/journal.pone.0266386},
number = {4 April},
pages = {e0266386},
doi = {10.1371/journal.pone.0266386}
}
MLA
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MLA Copy
Dinas, Petros C., et al. “Prevalence of uncoupling protein one genetic polymorphisms and their relationship with cardiovascular and metabolic health.” PLoS ONE, vol. 17, no. 4 April, Apr. 2022, p. e0266386. https://doi.org/10.1371/journal.pone.0266386.