Complexation of Bi³⁺, Ac³⁺, Y³⁺, Lu³⁺, La³⁺ and Eu³⁺ with benzo-diaza-crown ether with carboxylic pendant arms

Polyaminopolycarboxylates are attractive ligands for binding cationic radionuclides for synthesis of radiopharmaceuticals with target delivery to tumor cells. Nowadays beta emitting Y−90 and Lu−177 are used as therapeutic agents, while Ac−225 and Bi−213 are considered as perspective for alpha therapy. In the present study new data on complexation of Y³⁺, Lu³⁺, Ac³⁺ and Bi³⁺ with 2,2’-(15-formyl-2,3,5,6,8,9,11,12-octahydrobenzo [b][1,4,10,7,13]trioxadiazacyclopentadecine-4,10- diyl)diacetic acid are presented. For ligand and complexes characterization potentiometric titration, solvent extraction, chromatography and solubility techniques were applied. The highest values of stability constants within the range of log K = 5.8 – 7.5 were found for Ac³⁺ and REE. Fast complex formation is established which is beneficial for practical applications in radiopharmaceutical synthesis.