Brain-Derived Neurotrophic Factor Produces Antidepressant Effects in Behavioral Models of Depression
Yukihiko Shirayama
1
,
Andrew C.-H. Chen
2
,
Shin NAKAGAWA
2
,
David. G. Russell
2
,
RONALD S. DUMAN
2
Publication type: Journal Article
Publication date: 2002-04-15
scimago Q1
wos Q2
SJR: 1.963
CiteScore: 8.0
Impact factor: 4.0
ISSN: 02706474, 15292401
General Neuroscience
Abstract
Previous studies demonstrated that antidepressant treatment increases the expression of brain-derived neurotrophic factor (BDNF) in rat hippocampus. The present study was conducted to test the hypothesis that BDNF in the hippocampus produces an antidepressant effect in behavioral models of depression, the learned helplessness (LH) and forced swim test (FST) paradigms. A single bilateral infusion of BDNF into the dentate gyrus of hippocampus produced an antidepressant effect in both the LH and FST that was comparable in magnitude with repeated systemic administration of a chemical antidepressant. These effects were observed as early as 3 d after a single infusion of BDNF and lasted for at least 10 d. Similar effects were observed with neurotrophin-3 (NT-3) but not nerve growth factor. Infusions of BDNF and NT-3 did not influence locomotor activity or passive avoidance. The results provide further support for the hypothesis that BDNF contributes to the therapeutic action of antidepressant treatment.
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Shirayama Y. et al. Brain-Derived Neurotrophic Factor Produces Antidepressant Effects in Behavioral Models of Depression // Journal of Neuroscience. 2002. Vol. 22. No. 8. pp. 3251-3261.
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Shirayama Y., Chen A. C., NAKAGAWA S., Russell D. G., DUMAN R. S. Brain-Derived Neurotrophic Factor Produces Antidepressant Effects in Behavioral Models of Depression // Journal of Neuroscience. 2002. Vol. 22. No. 8. pp. 3251-3261.
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TY - JOUR
DO - 10.1523/JNEUROSCI.22-08-03251.2002
UR - https://doi.org/10.1523/JNEUROSCI.22-08-03251.2002
TI - Brain-Derived Neurotrophic Factor Produces Antidepressant Effects in Behavioral Models of Depression
T2 - Journal of Neuroscience
AU - Shirayama, Yukihiko
AU - Chen, Andrew C.-H.
AU - NAKAGAWA, Shin
AU - Russell, David. G.
AU - DUMAN, RONALD S.
PY - 2002
DA - 2002/04/15
PB - Society for Neuroscience
SP - 3251-3261
IS - 8
VL - 22
SN - 0270-6474
SN - 1529-2401
ER -
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@article{2002_Shirayama,
author = {Yukihiko Shirayama and Andrew C.-H. Chen and Shin NAKAGAWA and David. G. Russell and RONALD S. DUMAN},
title = {Brain-Derived Neurotrophic Factor Produces Antidepressant Effects in Behavioral Models of Depression},
journal = {Journal of Neuroscience},
year = {2002},
volume = {22},
publisher = {Society for Neuroscience},
month = {apr},
url = {https://doi.org/10.1523/JNEUROSCI.22-08-03251.2002},
number = {8},
pages = {3251--3261},
doi = {10.1523/JNEUROSCI.22-08-03251.2002}
}
Cite this
MLA
Copy
Shirayama, Yukihiko, et al. “Brain-Derived Neurotrophic Factor Produces Antidepressant Effects in Behavioral Models of Depression.” Journal of Neuroscience, vol. 22, no. 8, Apr. 2002, pp. 3251-3261. https://doi.org/10.1523/JNEUROSCI.22-08-03251.2002.