DASIEL OSCAR Borroto eskuela BORROTO-ESCUELA

I have been primarily focused on understanding the molecular integration of signals in the brain via receptor-receptor interaction in the heteroreceptor complexes and its functional effects which is a current scientific issue of high relevance for brain function and integration. And whether alterations in specific heteroreceptor complexes and their receptor-receptor interactions are associated with and/or play a role in pathogenetic mechanisms contributing to brain disease development, inter alia Parkinson's disease, schizophrenia, addiction and depression. I'm very excited by the tremendous potential of the field of heteroreceptor complexes in the CNS and their receptor-receptor interactions. They offer novel targets for treatment of psychiatry and neurological disorders. My small daily ambition is to be part of this novel exciting field in Neurosciences. And also to develop new methods to describe in a better way receptor-receptor interactions in the brain. I have also a strong interest in setting up and improve the newly developed in situ proximity ligation assays for identification and study of heteroreceptor complexes in the brain. Furthermore, on novel adaptations of conventional Light Resonance Energy Transfer-based methods (BRET, FRET, TR-FRET, BiFC) to made possible the study GPCR oligomerization dynamics in heterologous expression systems and neurons.