Open Access
Russian Open Medical Journal, volume 9, issue 1
Hypoxia is a key mechanism for regulating inflammation in ulcerative colitis
Publication type: Journal Article
Publication date: 2020-03-31
Journal:
Russian Open Medical Journal
Quartile SCImago
Q4
Quartile WOS
—
Impact factor: 0.4
ISSN: 23043415
General Medicine
Abstract
Intestinal bowel diseases (IBD), including ulcerative colitis (UC), is the group of difficult to diagnose widespread among the population diseases. Pathogenesis of the disease is associated with a complex interaction of the genetic factors, the environment, the microbiome and the unpredicted reaction of the immune system, and the existing treatment methods are not effective enough. It is known, that hypoxia plays a key role in both system and local inflammatory reactions, mainly due to microcirculatory disorders and disseminated intravascular coagulation. Therefore a lot of studies have demonstrated that severity of any inflammatory diseases, including Crohn's disease (CD) and UC depends on hypoxia resistance. In this review we discussed microcirculation of blood and physiological hypoxia in the intestine, the role of hypoxia-inducible factors in the development of IBD and UC, as well as their influence on the severity of the inflammatory process. Authors described the protective effect of various PHD inhibitors and its benefits and disadvantages, so as new approaches of searching of very specific low molecular weight substanses as drugs for the control of IBD and UC.
Citations by journals
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1
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Biomedicines
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Biomedicines
1 publication, 25%
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Science and Innovations in Medicine
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Science and Innovations in Medicine
1 publication, 25%
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International Journal of Molecular Sciences
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International Journal of Molecular Sciences
1 publication, 25%
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Drug Research
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Drug Research
1 publication, 25%
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1
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Citations by publishers
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1
2
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Multidisciplinary Digital Publishing Institute (MDPI)
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Multidisciplinary Digital Publishing Institute (MDPI)
2 publications, 50%
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Samara State Medical University
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Samara State Medical University
1 publication, 25%
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Thieme
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Thieme
1 publication, 25%
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1
2
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- We do not take into account publications that without a DOI.
- Statistics recalculated only for publications connected to researchers, organizations and labs registered on the platform.
- Statistics recalculated weekly.
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Postovalova E. A. et al. Hypoxia is a key mechanism for regulating inflammation in ulcerative colitis // Russian Open Medical Journal. 2020. Vol. 9. No. 1.
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Postovalova E. A., Makarova O., Kosyreva A., Dzhalilova D. Hypoxia is a key mechanism for regulating inflammation in ulcerative colitis // Russian Open Medical Journal. 2020. Vol. 9. No. 1.
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TY - JOUR
DO - 10.15275/rusomj.2020.0101
UR - https://doi.org/10.15275%2Frusomj.2020.0101
TI - Hypoxia is a key mechanism for regulating inflammation in ulcerative colitis
T2 - Russian Open Medical Journal
AU - Postovalova, E A
AU - Makarova, O.
AU - Kosyreva, Anna
AU - Dzhalilova, Dzhuliia
PY - 2020
DA - 2020/03/31 00:00:00
PB - Russian Open Medical Journal
IS - 1
VL - 9
SN - 2304-3415
ER -
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@article{2020_Postovalova,
author = {E A Postovalova and O. Makarova and Anna Kosyreva and Dzhuliia Dzhalilova},
title = {Hypoxia is a key mechanism for regulating inflammation in ulcerative colitis},
journal = {Russian Open Medical Journal},
year = {2020},
volume = {9},
publisher = {Russian Open Medical Journal},
month = {mar},
url = {https://doi.org/10.15275%2Frusomj.2020.0101},
number = {1},
doi = {10.15275/rusomj.2020.0101}
}