Open Access
Journal of Inflammation Research, volume Volume 12, pages 73-86
Dependence of the severity of the systemic inflammatory response on resistance to hypoxia in male Wistar rats
Kosyreva Anna
2
,
Diatroptov Mikhail E
,
Ponomarenko Elena A
,
Ponomarenko Elena A
2
,
Tsvetkov Ivan S
,
Zolotova N A
2
,
Zolotova Natalia A
,
Mkhitarov V A
3
,
Mkhitarov Vladimir A
,
Khochanskiy D N
2
,
Publication type: Journal Article
Publication date: 2019-03-10
Journal:
Journal of Inflammation Research
Quartile SCImago
Q2
Quartile WOS
Q2
Impact factor: 4.5
ISSN: 11787031
PubMed ID:
30881082
Immunology
Immunology and Allergy
Abstract
Purpose The aim of the study was to characterize the severity of the systemic inflammatory response induced by lipopolysaccharide (LPS) in animals with different resistance levels to hypoxia. Materials and methods Two to three months old male Wistar rats (220–240 g) were divided according to hypoxia tolerance in a hypobaric chamber. After a month, they were injected intraperitoneally with Escherichia coli LPS at a dose of 1.5 mg/kg. After 3, 6 and 24 hours of LPS injection, we studied the levels of IL-1β, C-reactive protein (CRP) and TGF-β in the serum, the expression of Hif-1α and Nf-kb in the liver, morphological disorders in the lung and ex vivo production of IL-10 by splenic cells activated by ConA. Results In the early periods after the injection of LPS, increase in Nf-kb expression in the liver was observed only in the rats susceptible to hypoxia. After 6 hours of LPS injection, the number of neutrophils in the interalveolar septa of the lungs of rats susceptible to hypoxia was higher than in tolerant rats. This points to the development of more pronounced LPS-induced inflammation in the rats susceptible to hypoxia and is accompanied by increased expression of Hif-1α in the liver after 6 hours of LPS administration, serum IL-1β level after 3 hours and CRP level after 24 hours. The production of the anti-inflammatory cytokine IL-10 by the spleen was significantly decreased after 6 hours of LPS injection only in the animals tolerant to hypoxia. After 24 hours of LPS injection, a significant decrease in serum TGF-β level occurred in the rats tolerant to hypoxia in comparison with the control group, which improved the survival rates of the animals. Conclusion We have demonstrated the differences in the severity of the LPS-induced inflammatory response in male Wistar rats with different resistance levels to hypoxia. Rats susceptible to hypoxia are characterized by a more pronounced inflammatory response induced by LPS.
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Dzhalilova D. et al. Dependence of the severity of the systemic inflammatory response on resistance to hypoxia in male Wistar rats // Journal of Inflammation Research. 2019. Vol. Volume 12. pp. 73-86.
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Dzhalilova D., Kosyreva A., Diatroptov M. E., Diatroptov M. E., Ponomarenko E. A., Ponomarenko E. A., Tsvetkov I. S., Tsvetkov I. S., Zolotova N. A., Zolotova N. A., Mkhitarov V. A., Mkhitarov V. A., Khochanskiy D. N., Makarova O. V. Dependence of the severity of the systemic inflammatory response on resistance to hypoxia in male Wistar rats // Journal of Inflammation Research. 2019. Vol. Volume 12. pp. 73-86.
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TY - JOUR
DO - 10.2147/JIR.S194581
UR - https://doi.org/10.2147%2FJIR.S194581
TI - Dependence of the severity of the systemic inflammatory response on resistance to hypoxia in male Wistar rats
T2 - Journal of Inflammation Research
AU - Dzhalilova, Dzhuliia
AU - Kosyreva, Anna
AU - Khochanskiy, D N
AU - Makarova, Olga V.
AU - Diatroptov, Mikhail E
AU - Ponomarenko, Elena A
AU - Tsvetkov, Ivan S
AU - Zolotova, Natalia A
AU - Mkhitarov, Vladimir A
AU - Diatroptov, Mikhail E
AU - Ponomarenko, Elena A
AU - Tsvetkov, Ivan Sergeevich
AU - Zolotova, N A
AU - Mkhitarov, V A
PY - 2019
DA - 2019/03/10 00:00:00
PB - Dove Medical Press
SP - 73-86
VL - Volume 12
PMID - 30881082
SN - 1178-7031
ER -
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@article{2019_Dzhalilova,
author = {Dzhuliia Dzhalilova and Anna Kosyreva and D N Khochanskiy and Olga V. Makarova and Mikhail E Diatroptov and Elena A Ponomarenko and Ivan S Tsvetkov and Natalia A Zolotova and Vladimir A Mkhitarov and Mikhail E Diatroptov and Elena A Ponomarenko and Ivan Sergeevich Tsvetkov and N A Zolotova and V A Mkhitarov},
title = {Dependence of the severity of the systemic inflammatory response on resistance to hypoxia in male Wistar rats},
journal = {Journal of Inflammation Research},
year = {2019},
volume = {Volume 12},
publisher = {Dove Medical Press},
month = {mar},
url = {https://doi.org/10.2147%2FJIR.S194581},
pages = {73--86},
doi = {10.2147/JIR.S194581}
}