Recent Development and SAR Analysis of Colchicine Binding Site Inhibitors
Publication type: Journal Article
Publication date: 2009-08-20
scimago Q2
wos Q3
SJR: 0.662
CiteScore: 8.5
Impact factor: 3.3
ISSN: 13895575, 18755607
PubMed ID:
19817710
Drug Discovery
General Medicine
Pharmacology
Abstract
Microtubules are cytoskeletal components that play important roles in a number of cellular processes. Colchicine binding site inhibitors (CSIs) is one major class of tubulin polymerization inhibitors, inhibiting microtubule polymerization and blocking cell proliferation at metaphase during mitosis. Many CSIs were discovered or designed and synthesized as anticancer agents in the past several years and great progress had been made. Here, we discuss the insights gained so far relevant to the mechanism of CSIs and their common pharmacophore. The recent development of CSIs with their biological activity and structure-activity relationship (SAR) are also reviewed.
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Metrics
66
Total citations:
66
Citations from 2024:
4
(6.06%)
Cite this
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RIS |
BibTex |
MLA
Cite this
GOST
Copy
Chen J. et al. Recent Development and SAR Analysis of Colchicine Binding Site Inhibitors // Mini-Reviews in Medicinal Chemistry. 2009. Vol. 9. No. 10. pp. 1174-1190.
GOST all authors (up to 50)
Copy
Chen J. Recent Development and SAR Analysis of Colchicine Binding Site Inhibitors // Mini-Reviews in Medicinal Chemistry. 2009. Vol. 9. No. 10. pp. 1174-1190.
Cite this
RIS
Copy
TY - JOUR
DO - 10.2174/138955709789055234
UR - https://doi.org/10.2174/138955709789055234
TI - Recent Development and SAR Analysis of Colchicine Binding Site Inhibitors
T2 - Mini-Reviews in Medicinal Chemistry
AU - Chen, Jing
PY - 2009
DA - 2009/08/20
PB - Bentham Science Publishers Ltd.
SP - 1174-1190
IS - 10
VL - 9
PMID - 19817710
SN - 1389-5575
SN - 1875-5607
ER -
Cite this
BibTex (up to 50 authors)
Copy
@article{2009_Chen,
author = {Jing Chen},
title = {Recent Development and SAR Analysis of Colchicine Binding Site Inhibitors},
journal = {Mini-Reviews in Medicinal Chemistry},
year = {2009},
volume = {9},
publisher = {Bentham Science Publishers Ltd.},
month = {aug},
url = {https://doi.org/10.2174/138955709789055234},
number = {10},
pages = {1174--1190},
doi = {10.2174/138955709789055234}
}
Cite this
MLA
Copy
Chen, Jing, et al. “Recent Development and SAR Analysis of Colchicine Binding Site Inhibitors.” Mini-Reviews in Medicinal Chemistry, vol. 9, no. 10, Aug. 2009, pp. 1174-1190. https://doi.org/10.2174/138955709789055234.