Berberine: A Promising Natural Isoquinoline Alkaloid for the Development of Hypolipidemic Drugs
2
Jiangsu Kanion Pharmaceutical Co., Ltd., 58 Haichang South Road, Lianyungang 222001, China
|
Publication type: Journal Article
Publication date: 2020-09-09
scimago Q2
wos Q3
SJR: 0.610
CiteScore: 6.4
Impact factor: 3.3
ISSN: 15680266, 18734294
PubMed ID:
32901585
Drug Discovery
General Medicine
Abstract
Berberine, as a representative isoquinoline alkaloid, exhibits significant hypolipidemic activity in both animal models and clinical trials. Recently, a large number of studies on the lipid-lowering mechanism of berberine and studies for improving its hypolipidemic activity have been reported, but for the most part, they have been either incomplete or not comprehensive. In addition, there have been a few specific reviews on the lipid-reducing effect of berberine. In this paper, the physicochemical properties, the lipid-lowering mechanism, and studies of the modification of berberine all are discussed to promote the development of berberine as a lipid-lowering agent. Subsequently, this paper provides some insights into the deficiencies of berberine in the study of lipid-lowering drug, and based on the situation, some proposals are put forward.
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Total citations:
37
Citations from 2024:
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(45.94%)
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GOST
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Li D. et al. Berberine: A Promising Natural Isoquinoline Alkaloid for the Development of Hypolipidemic Drugs // Current Topics in Medicinal Chemistry. 2020. Vol. 20. No. 28. pp. 2634-2647.
GOST all authors (up to 50)
Copy
Li D., Pan Yu., Xiao W., Wang Z., Zhao L. Berberine: A Promising Natural Isoquinoline Alkaloid for the Development of Hypolipidemic Drugs // Current Topics in Medicinal Chemistry. 2020. Vol. 20. No. 28. pp. 2634-2647.
Cite this
RIS
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TY - JOUR
DO - 10.2174/1568026620666200908165913
UR - https://doi.org/10.2174/1568026620666200908165913
TI - Berberine: A Promising Natural Isoquinoline Alkaloid for the Development of Hypolipidemic Drugs
T2 - Current Topics in Medicinal Chemistry
AU - Li, Dong-dong
AU - Pan, Yu
AU - Xiao, Wei
AU - Wang, Zhen-Zhong
AU - Zhao, Lin-Guo
PY - 2020
DA - 2020/09/09
PB - Bentham Science Publishers Ltd.
SP - 2634-2647
IS - 28
VL - 20
PMID - 32901585
SN - 1568-0266
SN - 1873-4294
ER -
Cite this
BibTex (up to 50 authors)
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@article{2020_Li,
author = {Dong-dong Li and Yu Pan and Wei Xiao and Zhen-Zhong Wang and Lin-Guo Zhao},
title = {Berberine: A Promising Natural Isoquinoline Alkaloid for the Development of Hypolipidemic Drugs},
journal = {Current Topics in Medicinal Chemistry},
year = {2020},
volume = {20},
publisher = {Bentham Science Publishers Ltd.},
month = {sep},
url = {https://doi.org/10.2174/1568026620666200908165913},
number = {28},
pages = {2634--2647},
doi = {10.2174/1568026620666200908165913}
}
Cite this
MLA
Copy
Li, Dong-dong, et al. “Berberine: A Promising Natural Isoquinoline Alkaloid for the Development of Hypolipidemic Drugs.” Current Topics in Medicinal Chemistry, vol. 20, no. 28, Sep. 2020, pp. 2634-2647. https://doi.org/10.2174/1568026620666200908165913.