Colchicine: A Review on Chemical Structure and Clinical Usage
1
Department of Pharmaceutical Chemistry & Drug Control, Faculty of Pharmacy, Arab International University, Daraa, Syrian Arab Republic
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3
Department of Pharmaceutical Chemistry & Drug Control, Faculty of Pharmacy, Arab International University, Daraa, Syrian Arab Republic
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Publication type: Journal Article
Publication date: 2017-10-19
scimago Q3
SJR: 0.288
CiteScore: 3.3
Impact factor: —
ISSN: 18715265, 22123989
PubMed ID:
29046164
General Medicine
Pharmacology
Molecular Medicine
Microbiology (medical)
Abstract
For many years, colchicine has been used for therapeutic purposes and has been given considerable attention because of its association with tubulin and inhibition of small tubular polymerization. Colchicine is an alkaloid extracted from the colchicum autumnale plant, having molecular formula C22H25NO6, and consists of three rings. Many studies are concerned with structural changes in order to increase their pharmacological effectiveness and reduce the side effects of toxicity arising from it. The therapeutic use of colchicine has been mainly documented in Gout, Familial Mediterranean Fever, and many other diseases such as atrial fibrillation. This review summarizes the history of chemical structure of colchicine and presents some of its analogues. Furthermore, it shows binding mechanism with target protein when colchicine is used as a therapeutic drug, and gives a light spot on some studies that discuss the safe use of colchicine.
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41
Total citations:
41
Citations from 2024:
11
(26.83%)
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GOST
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Alkadi H., Khubeiz M. J., Jbeily R. Colchicine: A Review on Chemical Structure and Clinical Usage // Infectious Disorders - Drug Targets. 2017. Vol. 18. No. 2. pp. 105-121.
GOST all authors (up to 50)
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Alkadi H., Khubeiz M. J., Jbeily R. Colchicine: A Review on Chemical Structure and Clinical Usage // Infectious Disorders - Drug Targets. 2017. Vol. 18. No. 2. pp. 105-121.
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TY - JOUR
DO - 10.2174/1871526517666171017114901
UR - https://doi.org/10.2174/1871526517666171017114901
TI - Colchicine: A Review on Chemical Structure and Clinical Usage
T2 - Infectious Disorders - Drug Targets
AU - Alkadi, Hourieh
AU - Khubeiz, Mohamad Jowad
AU - Jbeily, Rajwa
PY - 2017
DA - 2017/10/19
PB - Bentham Science Publishers Ltd.
SP - 105-121
IS - 2
VL - 18
PMID - 29046164
SN - 1871-5265
SN - 2212-3989
ER -
Cite this
BibTex (up to 50 authors)
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@article{2017_Alkadi,
author = {Hourieh Alkadi and Mohamad Jowad Khubeiz and Rajwa Jbeily},
title = {Colchicine: A Review on Chemical Structure and Clinical Usage},
journal = {Infectious Disorders - Drug Targets},
year = {2017},
volume = {18},
publisher = {Bentham Science Publishers Ltd.},
month = {oct},
url = {https://doi.org/10.2174/1871526517666171017114901},
number = {2},
pages = {105--121},
doi = {10.2174/1871526517666171017114901}
}
Cite this
MLA
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Alkadi, Hourieh, et al. “Colchicine: A Review on Chemical Structure and Clinical Usage.” Infectious Disorders - Drug Targets, vol. 18, no. 2, Oct. 2017, pp. 105-121. https://doi.org/10.2174/1871526517666171017114901.