Gold nanoparticles for multimodal high-resolution imaging of transplanted cells for retinal replacement therapy
Yoav Chemla
1, 2
,
Oshra Betzer
2, 3
,
Amos Markus
1
,
Nairouz Farah
1
,
Menachem Motiei
2, 3
,
Rachela Popovtzer
2, 3
,
Yossi Mandel
1, 2
Publication type: Journal Article
Publication date: 2019-07-24
scimago Q2
wos Q2
SJR: 0.572
CiteScore: 6.4
Impact factor: 3.9
ISSN: 17435889, 17486963, 25225065, 25225073
PubMed ID:
31339056
Medicine (miscellaneous)
General Materials Science
Bioengineering
Biomedical Engineering
Development
Abstract
Aim: Longitudinal tracking of transplanted cells in clinical and experimental setups is crucial for evaluating the efficiency of retinal cell replacement therapies. Materials & methods: Gold nanoparticle-labeled photoreceptor precursors were transplanted in the vitreous and subretinal space of rats and were longitudinally tracked for over a month using optical coherence tomography, computed tomography and fluorescence fundus imaging. Results: This multimodal imaging approach enabled high-resolution long-term tracking and estimation of cell survival in the retina and vitreous, while displaying no toxic effects on the cells or the retina. Conclusion: These observations highlight the applicability of using gold nanoparticle for retinal cell tracking in existing experimental settings and its translational potential for providing more efficient retinal cell therapy in humans.
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Metrics
50
Total citations:
50
Citations from 2024:
18
(36%)
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BibTex |
MLA
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GOST
Copy
Chemla Y. et al. Gold nanoparticles for multimodal high-resolution imaging of transplanted cells for retinal replacement therapy // Nanomedicine. 2019. Vol. 14. No. 14. pp. 1857-1871.
GOST all authors (up to 50)
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Chemla Y., Betzer O., Markus A., Farah N., Motiei M., Popovtzer R., Mandel Y. Gold nanoparticles for multimodal high-resolution imaging of transplanted cells for retinal replacement therapy // Nanomedicine. 2019. Vol. 14. No. 14. pp. 1857-1871.
Cite this
RIS
Copy
TY - JOUR
DO - 10.2217/nnm-2018-0299
UR - https://doi.org/10.2217/nnm-2018-0299
TI - Gold nanoparticles for multimodal high-resolution imaging of transplanted cells for retinal replacement therapy
T2 - Nanomedicine
AU - Chemla, Yoav
AU - Betzer, Oshra
AU - Markus, Amos
AU - Farah, Nairouz
AU - Motiei, Menachem
AU - Popovtzer, Rachela
AU - Mandel, Yossi
PY - 2019
DA - 2019/07/24
PB - Taylor & Francis
SP - 1857-1871
IS - 14
VL - 14
PMID - 31339056
SN - 1743-5889
SN - 1748-6963
SN - 2522-5065
SN - 2522-5073
ER -
Cite this
BibTex (up to 50 authors)
Copy
@article{2019_Chemla,
author = {Yoav Chemla and Oshra Betzer and Amos Markus and Nairouz Farah and Menachem Motiei and Rachela Popovtzer and Yossi Mandel},
title = {Gold nanoparticles for multimodal high-resolution imaging of transplanted cells for retinal replacement therapy},
journal = {Nanomedicine},
year = {2019},
volume = {14},
publisher = {Taylor & Francis},
month = {jul},
url = {https://doi.org/10.2217/nnm-2018-0299},
number = {14},
pages = {1857--1871},
doi = {10.2217/nnm-2018-0299}
}
Cite this
MLA
Copy
Chemla, Yoav, et al. “Gold nanoparticles for multimodal high-resolution imaging of transplanted cells for retinal replacement therapy.” Nanomedicine, vol. 14, no. 14, Jul. 2019, pp. 1857-1871. https://doi.org/10.2217/nnm-2018-0299.