Nanomedicine

, volume 17 , issue 18 , pages 1217-1235

Alpha-fetoprotein mediated targeting of polymeric nanoparticles to treat solid tumors.

Mariya B Sokol ^{1, 2}

Nikita G Yabbarov ^{1, 2}

Mariia R Mollaeva ^{1, 2}

Margarita V Chirkina ^{1, 2}

Murad D Mollaev ^{2, 3}

Artur I Zabolotsky ^{2, 4}

Sergey L Kuznetsov ⁵

Elena D Nikolskaya ^{1, 2}

Hide authors affiliations Show authors affiliations: 5 affiliations

NM Emanuel Institute of Biochemical Physics of Russian Academy of Sciences, Moscow, 119334, Russia |

JSC Russian Research Center for Molecular Diagnostics and Therapy, Moscow, 117149, Russia |

Dmitry Rogachev National Medical Research Center of Pediatric Hematology, Oncology and Immunology, Moscow, 117198, Russia |

⁴

Lomonosov Moscow State University, Biological Faculty, Department of Biochemistry, Moscow, 119991, Russia |

⁵

National Research Center Kurchatov Institute, Moscow, 123182, Russia |

Publication type: Journal Article

Publication date: 2022-08-01

Taylor & Francis

Nanomedicine

scimago Q2

wos Q2

SJR: 0.572

CiteScore: 6.4

Impact factor: 3.9

ISSN: 17435889, 17486963, 25225065, 25225073

DOI: 10.2217/nnm-2022-0097

Copy DOI

PubMed ID: 36136593

Medicine (miscellaneous)

General Materials Science

Bioengineering

Biomedical Engineering

Development

Abstract

Background: Serious side effects caused by paclitaxel formulation, containing toxic solubilizer Cremophor^® EL, and its nonspecific accumulation greatly limit clinical paclitaxel application. Aim: To design paclitaxel-loaded copolymer of lactic and glycolic acids nanoparticles decorated with alpha-fetoprotein third domain (rAFP3d-NP) to increase paclitaxel safety profile. Methods: rAFP3d-NP was obtained via carbodiimide technique. Results: The particles were characterized with high paclitaxel loading content of 5% and size of 280 nm. rAFP3d-NP revealed biphasic profile with 67% release of paclitaxel during 220 h. Increased area under the curve_inf and mean residence time values after rAFP3d-NP administration confirmed prolonged blood circulation compared with paclitaxel. rAFP3d-NP demonstrated significant tumor growth inhibition at 4T1 and SKOV-3 models. Conclusion: rAFP3d-NP is a promising delivery system for paclitaxel and can be applied similarly for delivery of other hydrophobic drugs.

Found

7 citations

Nikolskaya Elena

🤝

PhD in Chemistry

64 publications, 421 citations

h-index: 11

Emanuel Institute of Biochemical Physics of the Russian Academy of Sciences

Research interests

Nanomaterials

Nanotechnology

Personalized medicine

Targeted drug delivery

1 citation

Abakumov Maxim

PhD in Chemistry, associate professor

160 publications, 2 702 citations, 19 reviews

h-index: 28

National University of Science & Technology (MISiS)

Pirogov Russian National Research Medical University

1 citation

Maksimova Varvara

🥼 🤝

35 publications, 119 citations, 1 review

h-index: 7

N.N. Blokhin National Medical Research Center of Oncology

Research interests

Chemical carcinogenesis

Epigenetic antitumor therapy

Mechanisms of epigenetic regulation of transcription

Xenobiotics

1 citation

Nikitin Aleksey

🤝

PhD in Chemistry

46 publications, 651 citations

h-index: 14

National University of Science & Technology (MISiS)

Pirogov Russian National Research Medical University

Mendeleev University of Chemical Technology of Russia

Research interests

"Smart" materials

Inorganic Chemistry

Magnetic hyperthermia

Magnetic materials

Magnetic resonance imaging (MRI)

Nanoparticles of metal oxides

Nanotechnology

Synthesis of nanoparticles

Targeted drug delivery

1 citation

Kuzmin Vladimir

393 publications, 2 922 citations

h-index: 27

Emanuel Institute of Biochemical Physics of the Russian Academy of Sciences

1 citation

Maltsev Alexander

PhD in Chemistry

17 publications, 45 citations

h-index: 4

Emanuel Institute of Biochemical Physics of the Russian Academy of Sciences

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GOST |

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GOST Copy

Sokol M. B. et al. Alpha-fetoprotein mediated targeting of polymeric nanoparticles to treat solid tumors. // Nanomedicine. 2022. Vol. 17. No. 18. pp. 1217-1235.

GOST all authors (up to 50) Copy

Sokol M. B., Yabbarov N. G., Mollaeva M. R., Chirkina M. V., Mollaev M. D., Zabolotsky A. I., Kuznetsov S. L., Nikolskaya E. D. Alpha-fetoprotein mediated targeting of polymeric nanoparticles to treat solid tumors. // Nanomedicine. 2022. Vol. 17. No. 18. pp. 1217-1235.

RIS |

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RIS Copy

TY - JOUR

DO - 10.2217/nnm-2022-0097

UR - https://doi.org/10.2217/nnm-2022-0097

TI - Alpha-fetoprotein mediated targeting of polymeric nanoparticles to treat solid tumors.

T2 - Nanomedicine

AU - Sokol, Mariya B

AU - Yabbarov, Nikita G

AU - Mollaeva, Mariia R

AU - Chirkina, Margarita V

AU - Mollaev, Murad D

AU - Zabolotsky, Artur I

AU - Kuznetsov, Sergey L

AU - Nikolskaya, Elena D

PY - 2022

DA - 2022/08/01

PB - Taylor & Francis

SP - 1217-1235

IS - 18

VL - 17

PMID - 36136593

SN - 1743-5889

SN - 1748-6963

SN - 2522-5065

SN - 2522-5073

ER -

BibTex |

Cite this

BibTex (up to 50 authors) Copy

@article{2022_Sokol,

author = {Mariya B Sokol and Nikita G Yabbarov and Mariia R Mollaeva and Margarita V Chirkina and Murad D Mollaev and Artur I Zabolotsky and Sergey L Kuznetsov and Elena D Nikolskaya},

title = {Alpha-fetoprotein mediated targeting of polymeric nanoparticles to treat solid tumors.},

journal = {Nanomedicine},

year = {2022},

volume = {17},

publisher = {Taylor & Francis},

month = {aug},

url = {https://doi.org/10.2217/nnm-2022-0097},

number = {18},

pages = {1217--1235},

doi = {10.2217/nnm-2022-0097}

}

MLA

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MLA Copy

Sokol, Mariya B., et al. “Alpha-fetoprotein mediated targeting of polymeric nanoparticles to treat solid tumors..” Nanomedicine, vol. 17, no. 18, Aug. 2022, pp. 1217-1235. https://doi.org/10.2217/nnm-2022-0097.

Publisher

Taylor & Francis

Journal

Nanomedicine

scimago Q2

wos Q2

SJR

0.572

CiteScore

6.4

Impact factor

3.9

ISSN

17435889 (Print)

17486963 (Electronic)

25225065 (Print)

25225073 (Electronic)

Labs

Laboratory of Biotechnologies and Nanostructures for targeted drug delivery

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