Nanomedicine, volume 17, issue 18, pages 1217-1235
Alpha-fetoprotein mediated targeting of polymeric nanoparticles to treat solid tumors.
Sokol Mariya B
1, 2
,
Yabbarov Nikita G
1, 2
,
Mollaeva Mariia R
1, 2
,
Chirkina Margarita V
1, 2
,
Mollaev Murad D
2, 3
,
Zabolotsky Artur I
2, 4
,
Nikolskaya Elena D
1, 2
1
2
JSC Russian Research Center for Molecular Diagnostics and Therapy, Moscow, 117149, Russia
|
Publication type: Journal Article
Publication date: 2022-08-01
Journal:
Nanomedicine
Quartile SCImago
Q1
Quartile WOS
Q1
Impact factor: 5.5
ISSN: 17435889, 17486963, 25225065, 25225073
Medicine (miscellaneous)
General Materials Science
Bioengineering
Biomedical Engineering
Development
Abstract
Background: Serious side effects caused by paclitaxel formulation, containing toxic solubilizer Cremophor® EL, and its nonspecific accumulation greatly limit clinical paclitaxel application. Aim: To design paclitaxel-loaded copolymer of lactic and glycolic acids nanoparticles decorated with alpha-fetoprotein third domain (rAFP3d-NP) to increase paclitaxel safety profile. Methods: rAFP3d-NP was obtained via carbodiimide technique. Results: The particles were characterized with high paclitaxel loading content of 5% and size of 280 nm. rAFP3d-NP revealed biphasic profile with 67% release of paclitaxel during 220 h. Increased area under the curveinf and mean residence time values after rAFP3d-NP administration confirmed prolonged blood circulation compared with paclitaxel. rAFP3d-NP demonstrated significant tumor growth inhibition at 4T1 and SKOV-3 models. Conclusion: rAFP3d-NP is a promising delivery system for paclitaxel and can be applied similarly for delivery of other hydrophobic drugs.
Citations by journals
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1
2
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Pharmaceutics
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Pharmaceutics
2 publications, 33.33%
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Polymers
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Polymers
2 publications, 33.33%
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Colloids and Surfaces B: Biointerfaces
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Colloids and Surfaces B: Biointerfaces
1 publication, 16.67%
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Biophysics (Russian Federation)
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Biophysics (Russian Federation)
1 publication, 16.67%
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1
2
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Citations by publishers
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1
2
3
4
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Multidisciplinary Digital Publishing Institute (MDPI)
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Multidisciplinary Digital Publishing Institute (MDPI)
4 publications, 66.67%
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Elsevier
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Elsevier
1 publication, 16.67%
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Pleiades Publishing
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Pleiades Publishing
1 publication, 16.67%
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1
2
3
4
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- We do not take into account publications that without a DOI.
- Statistics recalculated only for publications connected to researchers, organizations and labs registered on the platform.
- Statistics recalculated weekly.
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Sokol M. B. et al. Alpha-fetoprotein mediated targeting of polymeric nanoparticles to treat solid tumors. // Nanomedicine. 2022. Vol. 17. No. 18. pp. 1217-1235.
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Sokol M. B., Yabbarov N. G., Mollaeva M. R., Chirkina M. V., Mollaev M. D., Zabolotsky A. I., Kuznetsov S. L., Nikolskaya E. D. Alpha-fetoprotein mediated targeting of polymeric nanoparticles to treat solid tumors. // Nanomedicine. 2022. Vol. 17. No. 18. pp. 1217-1235.
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TY - JOUR
DO - 10.2217/nnm-2022-0097
UR - https://doi.org/10.2217%2Fnnm-2022-0097
TI - Alpha-fetoprotein mediated targeting of polymeric nanoparticles to treat solid tumors.
T2 - Nanomedicine
AU - Sokol, Mariya B
AU - Yabbarov, Nikita G
AU - Mollaeva, Mariia R
AU - Chirkina, Margarita V
AU - Mollaev, Murad D
AU - Zabolotsky, Artur I
AU - Kuznetsov, Sergey L
AU - Nikolskaya, Elena D
PY - 2022
DA - 2022/08/01 00:00:00
PB - Future Medicine
SP - 1217-1235
IS - 18
VL - 17
SN - 1743-5889
SN - 1748-6963
SN - 2522-5065
SN - 2522-5073
ER -
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@article{2022_Sokol,
author = {Mariya B Sokol and Nikita G Yabbarov and Mariia R Mollaeva and Margarita V Chirkina and Murad D Mollaev and Artur I Zabolotsky and Sergey L Kuznetsov and Elena D Nikolskaya},
title = {Alpha-fetoprotein mediated targeting of polymeric nanoparticles to treat solid tumors.},
journal = {Nanomedicine},
year = {2022},
volume = {17},
publisher = {Future Medicine},
month = {aug},
url = {https://doi.org/10.2217%2Fnnm-2022-0097},
number = {18},
pages = {1217--1235},
doi = {10.2217/nnm-2022-0097}
}
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Sokol, Mariya B., et al. “Alpha-fetoprotein mediated targeting of polymeric nanoparticles to treat solid tumors..” Nanomedicine, vol. 17, no. 18, Aug. 2022, pp. 1217-1235. https://doi.org/10.2217%2Fnnm-2022-0097.