Nanomedicine, издание 17, том 18, номера страниц: 1217-1235

Alpha-fetoprotein mediated targeting of polymeric nanoparticles to treat solid tumors.

Тип публикации: Journal Article
Дата публикации: 2022-08-01
Future Medicine
Future Medicine
Журнал:  Nanomedicine
Квартиль SCImago: Q1
Квартиль WOS: Q1
Impact factor: 5.5
ISSN: 17435889, 17486963
Medicine (miscellaneous)
General Materials Science
Bioengineering
Biomedical Engineering
Development
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Background: Serious side effects caused by paclitaxel formulation, containing toxic solubilizer Cremophor® EL, and its nonspecific accumulation greatly limit clinical paclitaxel application. Aim: To design paclitaxel-loaded copolymer of lactic and glycolic acids nanoparticles decorated with alpha-fetoprotein third domain (rAFP3d-NP) to increase paclitaxel safety profile. Methods: rAFP3d-NP was obtained via carbodiimide technique. Results: The particles were characterized with high paclitaxel loading content of 5% and size of 280 nm. rAFP3d-NP revealed biphasic profile with 67% release of paclitaxel during 220 h. Increased area under the curveinf and mean residence time values after rAFP3d-NP administration confirmed prolonged blood circulation compared with paclitaxel. rAFP3d-NP demonstrated significant tumor growth inhibition at 4T1 and SKOV-3 models. Conclusion: rAFP3d-NP is a promising delivery system for paclitaxel and can be applied similarly for delivery of other hydrophobic drugs.

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1. Sokol M. B. и др. Alpha-fetoprotein mediated targeting of polymeric nanoparticles to treat solid tumors // Nanomedicine. 2022. Т. 17. № 18. С. 1217–1235.
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TY - JOUR

DO - 10.2217/nnm-2022-0097

UR - http://dx.doi.org/10.2217/nnm-2022-0097

TI - Alpha-fetoprotein mediated targeting of polymeric nanoparticles to treat solid tumors

T2 - Nanomedicine

AU - Sokol, Mariya B

AU - Yabbarov, Nikita G

AU - Mollaeva, Mariia R

AU - Chirkina, Margarita V

AU - Mollaev, Murad D

AU - Zabolotsky, Artur I

AU - Kuznetsov, Sergey L

AU - Nikolskaya, Elena D

PY - 2022

DA - 2022/08

PB - Future Medicine Ltd

SP - 1217-1235

IS - 18

VL - 17

SN - 1743-5889

SN - 1748-6963

ER -

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@article{Sokol_2022,

doi = {10.2217/nnm-2022-0097},

url = {https://doi.org/10.2217%2Fnnm-2022-0097},

year = 2022,

month = {aug},

publisher = {Future Medicine Ltd},

volume = {17},

number = {18},

pages = {1217--1235},

author = {Mariya B Sokol and Nikita G Yabbarov and Mariia R Mollaeva and Margarita V Chirkina and Murad D Mollaev and Artur I Zabolotsky and Sergey L Kuznetsov and Elena D Nikolskaya},

title = {Alpha-fetoprotein mediated targeting of polymeric nanoparticles to treat solid tumors},

journal = {Nanomedicine}

}

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Sokol, Mariya B., et al. “Alpha-Fetoprotein Mediated Targeting of Polymeric Nanoparticles to Treat Solid Tumors.” Nanomedicine, vol. 17, no. 18, Aug. 2022, pp. 1217–35. Crossref, https://doi.org/10.2217/nnm-2022-0097.