Nanomedicine, том 17, издание 18, номера страниц: 1217-1235

Alpha-fetoprotein mediated targeting of polymeric nanoparticles to treat solid tumors.

Sokol Maria 1, 2
Mollaev Murad D 2, 3
Zabolotsky Artur I 2, 4
Kuznetsov Sergey L 5
2
 
JSC Russian Research Center for Molecular Diagnostics and Therapy, Moscow, 117149, Russia
3
 
Dmitry Rogachev National Medical Research Center of Pediatric Hematology, Oncology and Immunology, Moscow, 117198, Russia
Тип документаJournal Article
Дата публикации2022-08
ИздательFuture Medicine Ltd.
Название журналаNanomedicine
Квартиль по SCImagoQ1
Квартиль по Web of ScienceQ1
Импакт-фактор 20216.10
ISSN17435889, 17486963
Краткое описание
Background: Serious side effects caused by paclitaxel formulation, containing toxic solubilizer Cremophor® EL, and its nonspecific accumulation greatly limit clinical paclitaxel application. Aim: To design paclitaxel-loaded copolymer of lactic and glycolic acids nanoparticles decorated with alpha-fetoprotein third domain (rAFP3d-NP) to increase paclitaxel safety profile. Methods: rAFP3d-NP was obtained via carbodiimide technique. Results: The particles were characterized with high paclitaxel loading content of 5% and size of 280 nm. rAFP3d-NP revealed biphasic profile with 67% release of paclitaxel during 220 h. Increased area under the curveinf and mean residence time values after rAFP3d-NP administration confirmed prolonged blood circulation compared with paclitaxel. rAFP3d-NP demonstrated significant tumor growth inhibition at 4T1 and SKOV-3 models. Conclusion: rAFP3d-NP is a promising delivery system for paclitaxel and can be applied similarly for delivery of other hydrophobic drugs.
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