Bulletin of Russian State Medical University, issue (3)2020, pages 49-57

Effects of empagliflozin and L-ornithine L-aspartate on behavior, cognitive functions, and physical performance in mice with experimentally induced steatohepatitis

Prikhodko Veronika A. ¹

Sysoev YuI ²

Poveryaeva MA ¹

Bunyat AV ¹

Karev VE ³

Ivkin DYu ¹

Sukhanov DS ¹

Shustov EB ¹

Okovityi SV ¹

Hide authors affiliations Show authors affiliations: 3 affiliations

Saint Petersburg State Chemical and Pharmaceutical University, Saint Petersburg, Russia |

Saint Petersburg State Chemical and Pharmaceutical University, Saint Petersburg, Russia; Institute of Translational Biomedicine, Saint Petersburg State University, Saint Petersburg, Russia |

Pediatric Research and Clinical Center for Infectious Diseases of FMBA, Saint Petersburg, Russia |

Publication type: Journal Article

Publication date: 2020-06-23

Pirogov Russian National Research Medical University

Journal: Bulletin of Russian State Medical University

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Impact factor: 0.2

ISSN: 25001094, 25421204

DOI: 10.24075/brsmu.2020.034

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General Medicine

Abstract

Non-alcoholic fatty liver disease (NAFLD) is a chronic condition characterized by disturbed carbohydrate and lipid metabolism and often complicated by psychoneurological symptoms, including anxiety, depression, memory deficit, and asthenia. Most studies of pharmacotherapy candidates for NAFLD focus on the ability of the tested drugs to restore the biochemical functions and morphology of the liver while their potential effects on the co-existing conditions remain overlooked. The aim of this paper was to investigate the effects of empagliflozin and L-ornithine L-aspartate (OA) on behavior, memory, and physical performance in C57BL/6 mice with experimentally induced NAFLD (6 months of a Western diet + weekly carbon tetrachloride injections). The disease affected animal behavior (locomotion speed decreased by 38% and 35%, p < 0.01; rearing increased by 432% and 279%, p < 0.05 etc.), induced long-term memory deficit (latency to find the target box increased by 108% in the Barnes maze, the number of errors increased by 439%, p < 0.05), and compromised physical performance (swimming time in the forced swim test dropped by 50%, p < 0.05 etc.). When administered during the high-calorie diet period, both drugs reduced anxiety (empagliflozin: the number of grooming bouts rose by 160%, p < 0.05 and 2173%, p < 0.01; time spent in the light compartment in the light/dark box test increased by 275%, p < 0.05, etc.; OA: time spent in the open arms of the maze increased by 267%, p < 0.05), and promoted memory retention in mice with NAFLD. OA improved physical performance (swimming time in the forced swimming test improved by 106%, p < 0.05, etc.). Thus, empagliflozin and OA can have a beneficial effect on cognitive functions, as well as behavior, and ameliorate asthenia in NAFLD.

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	1
Biomedicines	Biomedicines, 1, 33.33% Biomedicines 1 publication, 33.33%
Journal Biomed (BIOMEDICINE)	Journal Biomed (BIOMEDICINE), 1, 33.33% Journal Biomed (BIOMEDICINE) 1 publication, 33.33%
Livers	Livers, 1, 33.33% Livers 1 publication, 33.33%
	1

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Multidisciplinary Digital Publishing Institute (MDPI)	Multidisciplinary Digital Publishing Institute (MDPI), 2, 66.67% Multidisciplinary Digital Publishing Institute (MDPI) 2 publications, 66.67%
Scientific Center for Biomedical Technologies of the Federal Medical-Biological Agency	Scientific Center for Biomedical Technologies of the Federal Medical-Biological Agency, 1, 33.33% Scientific Center for Biomedical Technologies of the Federal Medical-Biological Agency 1 publication, 33.33%
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Prikhodko V. A. et al. Effects of empagliflozin and L-ornithine L-aspartate on behavior, cognitive functions, and physical performance in mice with experimentally induced steatohepatitis // Bulletin of Russian State Medical University. 2020. Vol. (3)2020. pp. 49-57.

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Prikhodko V. A., Sysoev Y., Poveryaeva M., Bunyat A., Karev V., Ivkin D., Sukhanov D., Shustov E., Okovityi S. Effects of empagliflozin and L-ornithine L-aspartate on behavior, cognitive functions, and physical performance in mice with experimentally induced steatohepatitis // Bulletin of Russian State Medical University. 2020. Vol. (3)2020. pp. 49-57.

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RIS Copy

TY - JOUR

DO - 10.24075/brsmu.2020.034

UR - https://doi.org/10.24075%2Fbrsmu.2020.034

TI - Effects of empagliflozin and L-ornithine L-aspartate on behavior, cognitive functions, and physical performance in mice with experimentally induced steatohepatitis

T2 - Bulletin of Russian State Medical University

AU - Prikhodko, Veronika A.

AU - Sysoev, YuI

AU - Poveryaeva, MA

AU - Bunyat, AV

AU - Karev, VE

AU - Ivkin, DYu

AU - Sukhanov, DS

AU - Shustov, EB

AU - Okovityi, SV

PY - 2020

DA - 2020/06/23 00:00:00

PB - Pirogov Russian National Research Medical University

SP - 49-57

IS - (3)2020

SN - 2500-1094

SN - 2542-1204

ER -

BibTex

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BibTex Copy

@article{2020_Prikhodko,

author = {Veronika A. Prikhodko and YuI Sysoev and MA Poveryaeva and AV Bunyat and VE Karev and DYu Ivkin and DS Sukhanov and EB Shustov and SV Okovityi},

title = {Effects of empagliflozin and L-ornithine L-aspartate on behavior, cognitive functions, and physical performance in mice with experimentally induced steatohepatitis},

journal = {Bulletin of Russian State Medical University},

year = {2020},

publisher = {Pirogov Russian National Research Medical University},

month = {jun},

url = {https://doi.org/10.24075%2Fbrsmu.2020.034},

number = {(3)2020},

pages = {49--57},

doi = {10.24075/brsmu.2020.034}

}

Found error?

Publisher

Pirogov Russian National Research Medical University

Journal

Bulletin of Russian State Medical University

Quartile SCImago

Quartile WOS

—

Impact factor

0.2

ISSN

25001094 (Print)
25421204 (Electronic)

Labs

Department of Pharmacology and Clinical Pharmacology

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