Electronic Steric Factors in the Active Site of Metallo-β-Lactamase and Reactivity of Cephalosporin Antibiotics
Тип публикации: Journal Article
Дата публикации: 2019-05-01
scimago Q4
wos Q4
БС3
SJR: 0.153
CiteScore: 1.1
Impact factor: 0.5
ISSN: 00271314, 19350260
General Chemistry
Краткое описание
In this paper, the relationship of electronic steric factors in the active site of metallo-β-lactamase and reactivity of cephalosporin antibiotics is studied. The steric energy of the oxygen atom forming a temporary covalent bond in the structure of the transition state of the limiting stage characterizes the reactivity of the compounds. A linear relationship between this value and the macroscopic parameter of the stationary Michaelis–Menten kinetics (catalytic constant kcat) is proposed: the increase in the rate constant is associated with an increase in steric energy. Two-dimensional maps of the steric potential and steric energy density are analyzed.
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Khrenova M. G. et al. Electronic Steric Factors in the Active Site of Metallo-β-Lactamase and Reactivity of Cephalosporin Antibiotics // Moscow University Chemistry Bulletin. 2019. Vol. 74. No. 3. pp. 106-110.
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Khrenova M. G., Tomilko A. V., Tsirelson V. G. Electronic Steric Factors in the Active Site of Metallo-β-Lactamase and Reactivity of Cephalosporin Antibiotics // Moscow University Chemistry Bulletin. 2019. Vol. 74. No. 3. pp. 106-110.
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TY - JOUR
DO - 10.3103/S0027131419030076
UR - https://doi.org/10.3103/S0027131419030076
TI - Electronic Steric Factors in the Active Site of Metallo-β-Lactamase and Reactivity of Cephalosporin Antibiotics
T2 - Moscow University Chemistry Bulletin
AU - Khrenova, M. G.
AU - Tomilko, A V
AU - Tsirelson, V. G.
PY - 2019
DA - 2019/05/01
PB - Pleiades Publishing
SP - 106-110
IS - 3
VL - 74
SN - 0027-1314
SN - 1935-0260
ER -
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@article{2019_Khrenova,
author = {M. G. Khrenova and A V Tomilko and V. G. Tsirelson},
title = {Electronic Steric Factors in the Active Site of Metallo-β-Lactamase and Reactivity of Cephalosporin Antibiotics},
journal = {Moscow University Chemistry Bulletin},
year = {2019},
volume = {74},
publisher = {Pleiades Publishing},
month = {may},
url = {https://doi.org/10.3103/S0027131419030076},
number = {3},
pages = {106--110},
doi = {10.3103/S0027131419030076}
}
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Khrenova, M. G., et al. “Electronic Steric Factors in the Active Site of Metallo-β-Lactamase and Reactivity of Cephalosporin Antibiotics.” Moscow University Chemistry Bulletin, vol. 74, no. 3, May. 2019, pp. 106-110. https://doi.org/10.3103/S0027131419030076.