Moscow University Biological Sciences Bulletin, volume 73, issue 3, pages 124-129
Impairment of the Viability of Transformed Chinese Hamster Cells in a Nonsubcultured Culture under the Influence of Exogenous Oxidized Guanoside is Manifested Only in the Stationary Phase of Growth
Morgunova G V
1
,
Klebanov A A
1
Publication type: Journal Article
Publication date: 2018-07-01
Quartile SCImago
Q4
Quartile WOS
—
Impact factor: —
ISSN: 00963925, 1934791X
General Biochemistry, Genetics and Molecular Biology
General Agricultural and Biological Sciences
General Environmental Science
Abstract
Despite the fact that oxidation products of nucleotides and nucleosides are markers of oxidative stress, reports of the paradoxical ability of these compounds to protect cells from the harmful effects of reactive oxygen species began to appear more often. Among all nitrogenous bases, guanine is most susceptible to the influence of oxidative stress; therefore, guanosine is oxidized more often than other bases. In the present work, the effect of exogenous 8-oxo-2′-deoxyguanosine on the growth and “stationary phase aging” (accumulation of “age-related” changes in cultured cells during cell proliferation slowing down within a single passage and subsequent “aging” in the stationary growth phase) of nonsubcultured transformed Chinese hamster cells was studied. We showed that the nucleoside is rapidly absorbed by the cells from the medium, but it does not affect the growth of the culture, and impairs the viability of the cells in the late stationary growth phase. Thus, no mitogenic or geroprotective effect of 8-oxo-2′-deoxyguanosine was found.
Citations by journals
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Moscow University Biological Sciences Bulletin
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Moscow University Biological Sciences Bulletin
6 publications, 75%
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Biochemistry (Moscow)
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Biochemistry (Moscow)
1 publication, 12.5%
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Биохимия
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Биохимия
1 publication, 12.5%
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Citations by publishers
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Pleiades Publishing
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Pleiades Publishing
8 publications, 100%
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Morgunova G. V., Klebanov A. A. Impairment of the Viability of Transformed Chinese Hamster Cells in a Nonsubcultured Culture under the Influence of Exogenous Oxidized Guanoside is Manifested Only in the Stationary Phase of Growth // Moscow University Biological Sciences Bulletin. 2018. Vol. 73. No. 3. pp. 124-129.
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Morgunova G. V., Klebanov A. A. Impairment of the Viability of Transformed Chinese Hamster Cells in a Nonsubcultured Culture under the Influence of Exogenous Oxidized Guanoside is Manifested Only in the Stationary Phase of Growth // Moscow University Biological Sciences Bulletin. 2018. Vol. 73. No. 3. pp. 124-129.
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TY - JOUR
DO - 10.3103/S0096392518030136
UR - https://doi.org/10.3103%2FS0096392518030136
TI - Impairment of the Viability of Transformed Chinese Hamster Cells in a Nonsubcultured Culture under the Influence of Exogenous Oxidized Guanoside is Manifested Only in the Stationary Phase of Growth
T2 - Moscow University Biological Sciences Bulletin
AU - Klebanov, A A
AU - Morgunova, G V
PY - 2018
DA - 2018/07/01 00:00:00
PB - Pleiades Publishing
SP - 124-129
IS - 3
VL - 73
SN - 0096-3925
SN - 1934-791X
ER -
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@article{2018_Morgunova,
author = {A A Klebanov and G V Morgunova},
title = {Impairment of the Viability of Transformed Chinese Hamster Cells in a Nonsubcultured Culture under the Influence of Exogenous Oxidized Guanoside is Manifested Only in the Stationary Phase of Growth},
journal = {Moscow University Biological Sciences Bulletin},
year = {2018},
volume = {73},
publisher = {Pleiades Publishing},
month = {jul},
url = {https://doi.org/10.3103%2FS0096392518030136},
number = {3},
pages = {124--129},
doi = {10.3103/S0096392518030136}
}
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Morgunova, G. V., and A A Klebanov. “Impairment of the Viability of Transformed Chinese Hamster Cells in a Nonsubcultured Culture under the Influence of Exogenous Oxidized Guanoside is Manifested Only in the Stationary Phase of Growth.” Moscow University Biological Sciences Bulletin, vol. 73, no. 3, Jul. 2018, pp. 124-129. https://doi.org/10.3103%2FS0096392518030136.
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