Moscow University Biological Sciences Bulletin, volume 73, issue 4, pages 185-190
Cell Kinetic Approaches to the Search for Anti-Aging Drugs: Thirty Years After
Publication type: Journal Article
Publication date: 2018-10-01
Quartile SCImago
Q4
Quartile WOS
—
Impact factor: —
ISSN: 00963925, 1934791X
General Biochemistry, Genetics and Molecular Biology
General Agricultural and Biological Sciences
General Environmental Science
Abstract
This is a brief overview of the ideas of the possibility of using the cell kinetic model developed by the author in the 1980s to test, in experiments on cell cultures, potential geroprotectors and geropromoters that slow down or accelerate, respectively, the aging process in animals and humans. The history of the evolution of this model—from estimation of only the cell reproduction rate and saturation density in a non-subcultured cell culture to constructing survival curves in the stationary phase of growth and to a further analysis of the possible interrelation between all parts of the curve of cells’ growth and subsequent dying out—is considered. Possible approaches to mathematical and statistical analysis of the data obtained within the framework of this model system are analyzed. It is emphasized that such studies can be carried out on cells of a very different nature (normal and transformed human and animal cells, plant cells, yeast, mycoplasmas, bacteria, etc.), which makes possible an evolutionary approach to the interpretation of the results obtained. At the same time, in the author’s opinion, the most promising experiments are those carried out on immortalized cells of humans and animals, since they are not cancerous on the one hand and have an unlimited mitotic potential on the other hand and, therefore, do not “age” in the process of numerous divisions, as, for example, normal human diploid fibroblasts do. It is assumed that the appropriate mathematical analysis of the entire growth and dying out curve of a non-subcultured cell culture (from seeding into a culture flask to the complete death of all cells) may allow the clarification of certain relationships between the development and aging of a multicellular organism and to increase the reliability of identifying promising geroprotectors.
Citations by journals
|
1
2
3
4
5
6
7
|
|
|
Moscow University Biological Sciences Bulletin
|
Moscow University Biological Sciences Bulletin
7 publications, 77.78%
|
|
Biochemistry (Moscow)
|
Biochemistry (Moscow)
1 publication, 11.11%
|
|
Биохимия
|
Биохимия
1 publication, 11.11%
|
|
1
2
3
4
5
6
7
|
Citations by publishers
|
1
2
3
4
5
6
7
8
9
|
|
|
Pleiades Publishing
|
Pleiades Publishing
9 publications, 100%
|
|
1
2
3
4
5
6
7
8
9
|
- We do not take into account publications that without a DOI.
- Statistics recalculated only for publications connected to researchers, organizations and labs registered on the platform.
- Statistics recalculated weekly.
{"yearsCitations":{"type":"bar","data":{"show":true,"labels":[2019,2020,2021,2022],"ids":[0,0,0,0],"codes":[0,0,0,0],"imageUrls":["","","",""],"datasets":[{"label":"Citations number","data":[3,2,3,1],"backgroundColor":["#3B82F6","#3B82F6","#3B82F6","#3B82F6"],"percentage":["33.33","22.22","33.33","11.11"],"barThickness":null}]},"options":{"indexAxis":"x","maintainAspectRatio":true,"scales":{"y":{"ticks":{"precision":0,"autoSkip":false,"font":{"family":"Montserrat"},"color":"#000000"}},"x":{"ticks":{"stepSize":1,"precision":0,"font":{"family":"Montserrat"},"color":"#000000"}}},"plugins":{"legend":{"position":"top","labels":{"font":{"family":"Montserrat"},"color":"#000000"}},"title":{"display":true,"text":"Citations per year","font":{"size":24,"family":"Montserrat","weight":600},"color":"#000000"}}}},"journals":{"type":"bar","data":{"show":true,"labels":["Moscow University Biological Sciences Bulletin","Biochemistry (Moscow)","\u0411\u0438\u043e\u0445\u0438\u043c\u0438\u044f"],"ids":[12722,2119,27074],"codes":[0,0,0],"imageUrls":["\/storage\/images\/resized\/oZgeErrVFhuDksyqFURLvYS1wtVSBWczh001igGo_medium.webp","\/storage\/images\/resized\/oZgeErrVFhuDksyqFURLvYS1wtVSBWczh001igGo_medium.webp","\/storage\/images\/resized\/oZgeErrVFhuDksyqFURLvYS1wtVSBWczh001igGo_medium.webp"],"datasets":[{"label":"","data":[7,1,1],"backgroundColor":["#3B82F6","#3B82F6","#3B82F6"],"percentage":[77.78,11.11,11.11],"barThickness":13}]},"options":{"indexAxis":"y","maintainAspectRatio":false,"scales":{"y":{"ticks":{"precision":0,"autoSkip":false,"font":{"family":"Montserrat"},"color":"#000000"}},"x":{"ticks":{"stepSize":null,"precision":0,"font":{"family":"Montserrat"},"color":"#000000"}}},"plugins":{"legend":{"position":"top","labels":{"font":{"family":"Montserrat"},"color":"#000000"}},"title":{"display":true,"text":"Journals","font":{"size":24,"family":"Montserrat","weight":600},"color":"#000000"}}}},"publishers":{"type":"bar","data":{"show":true,"labels":["Pleiades Publishing"],"ids":[101],"codes":[0],"imageUrls":["\/storage\/images\/resized\/oZgeErrVFhuDksyqFURLvYS1wtVSBWczh001igGo_medium.webp"],"datasets":[{"label":"","data":[9],"backgroundColor":["#3B82F6"],"percentage":[100],"barThickness":13}]},"options":{"indexAxis":"y","maintainAspectRatio":false,"scales":{"y":{"ticks":{"precision":0,"autoSkip":false,"font":{"family":"Montserrat"},"color":"#000000"}},"x":{"ticks":{"stepSize":null,"precision":0,"font":{"family":"Montserrat"},"color":"#000000"}}},"plugins":{"legend":{"position":"top","labels":{"font":{"family":"Montserrat"},"color":"#000000"}},"title":{"display":true,"text":"Publishers","font":{"size":24,"family":"Montserrat","weight":600},"color":"#000000"}}}}}
Metrics
Cite this
GOST |
RIS |
BibTex |
MLA
Cite this
GOST
Copy
Khokhlov A. N. Cell Kinetic Approaches to the Search for Anti-Aging Drugs: Thirty Years After // Moscow University Biological Sciences Bulletin. 2018. Vol. 73. No. 4. pp. 185-190.
GOST all authors (up to 50)
Copy
Khokhlov A. N. Cell Kinetic Approaches to the Search for Anti-Aging Drugs: Thirty Years After // Moscow University Biological Sciences Bulletin. 2018. Vol. 73. No. 4. pp. 185-190.
Cite this
RIS
Copy
TY - JOUR
DO - 10.3103/S0096392518040041
UR - https://doi.org/10.3103%2FS0096392518040041
TI - Cell Kinetic Approaches to the Search for Anti-Aging Drugs: Thirty Years After
T2 - Moscow University Biological Sciences Bulletin
AU - Khokhlov, A N
PY - 2018
DA - 2018/10/01 00:00:00
PB - Pleiades Publishing
SP - 185-190
IS - 4
VL - 73
SN - 0096-3925
SN - 1934-791X
ER -
Cite this
BibTex
Copy
@article{2018_Khokhlov,
author = {A N Khokhlov},
title = {Cell Kinetic Approaches to the Search for Anti-Aging Drugs: Thirty Years After},
journal = {Moscow University Biological Sciences Bulletin},
year = {2018},
volume = {73},
publisher = {Pleiades Publishing},
month = {oct},
url = {https://doi.org/10.3103%2FS0096392518040041},
number = {4},
pages = {185--190},
doi = {10.3103/S0096392518040041}
}
Cite this
MLA
Copy
Khokhlov, A. N.. “Cell Kinetic Approaches to the Search for Anti-Aging Drugs: Thirty Years After.” Moscow University Biological Sciences Bulletin, vol. 73, no. 4, Oct. 2018, pp. 185-190. https://doi.org/10.3103%2FS0096392518040041.
Profiles