Moscow University Biological Sciences Bulletin, volume 74, issue 4, pages 262-267
Demographic Approaches to the Study of Aging on Cell Cultures
Publication type: Journal Article
Publication date: 2019-10-01
Quartile SCImago
Q4
Quartile WOS
—
Impact factor: —
ISSN: 00963925, 1934791X
General Biochemistry, Genetics and Molecular Biology
General Agricultural and Biological Sciences
General Environmental Science
Abstract
Aging organisms die out in accordance with the “Gompertz law,” i.e., the probability of their death increases with age. Survival curve construction is the main tool for gerontologists to study aging and test antiaging drugs. The analysis of survival curves includes obtaining some indices characterizing aging of the population, for example, the average and maximum lifespan, the mortality rate, and the aging rate. Testing geroprotectors can be correctly performed only by obtaining such curves. The dying out of stationary cell populations—bacteria, yeast, and mammalian cell cultures—also occurs in accordance with the Gompertz equation. In this regard, it is reasonable to use the construction of survival curves and their analysis to study the “aging” of non-subcultured cell cultures and testing anti-aging drugs on them. We used this approach in our experiments, due to which we were able to detect the positive anti-aging effect of the Quinton Marine Plasma on stationary phase aging culture of Chinese hamster cells.
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Moscow University Biological Sciences Bulletin
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6 publications, 50%
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Citations by publishers
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Pleiades Publishing
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Pleiades Publishing
8 publications, 66.67%
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Moscow University Press
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Moscow University Press
4 publications, 33.33%
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- We do not take into account publications that without a DOI.
- Statistics recalculated only for publications connected to researchers, organizations and labs registered on the platform.
- Statistics recalculated weekly.
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Khokhlov A. N., Morgunova G. V., Klebanov A. A. Demographic Approaches to the Study of Aging on Cell Cultures // Moscow University Biological Sciences Bulletin. 2019. Vol. 74. No. 4. pp. 262-267.
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Khokhlov A. N., Morgunova G. V., Klebanov A. A. Demographic Approaches to the Study of Aging on Cell Cultures // Moscow University Biological Sciences Bulletin. 2019. Vol. 74. No. 4. pp. 262-267.
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TY - JOUR
DO - 10.3103/S0096392519040060
UR - https://doi.org/10.3103%2FS0096392519040060
TI - Demographic Approaches to the Study of Aging on Cell Cultures
T2 - Moscow University Biological Sciences Bulletin
AU - Klebanov, A A
AU - Khokhlov, A N
AU - Morgunova, G V
PY - 2019
DA - 2019/10/01 00:00:00
PB - Pleiades Publishing
SP - 262-267
IS - 4
VL - 74
SN - 0096-3925
SN - 1934-791X
ER -
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@article{2019_Khokhlov
author = {A A Klebanov and A N Khokhlov and G V Morgunova},
title = {Demographic Approaches to the Study of Aging on Cell Cultures},
journal = {Moscow University Biological Sciences Bulletin},
year = {2019},
volume = {74},
publisher = {Pleiades Publishing},
month = {oct},
url = {https://doi.org/10.3103%2FS0096392519040060},
number = {4},
pages = {262--267},
doi = {10.3103/S0096392519040060}
}
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Khokhlov, A. N., et al. “Demographic Approaches to the Study of Aging on Cell Cultures.” Moscow University Biological Sciences Bulletin, vol. 74, no. 4, Oct. 2019, pp. 262-267. https://doi.org/10.3103%2FS0096392519040060.
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