Moscow University Biological Sciences Bulletin, volume 74, issue 4, pages 262-267

Demographic Approaches to the Study of Aging on Cell Cultures

Publication typeJournal Article
Publication date2019-10-01
Quartile SCImago
Q4
Quartile WOS
Impact factor
ISSN00963925, 1934791X
General Biochemistry, Genetics and Molecular Biology
General Agricultural and Biological Sciences
General Environmental Science
Abstract
Aging organisms die out in accordance with the “Gompertz law,” i.e., the probability of their death increases with age. Survival curve construction is the main tool for gerontologists to study aging and test antiaging drugs. The analysis of survival curves includes obtaining some indices characterizing aging of the population, for example, the average and maximum lifespan, the mortality rate, and the aging rate. Testing geroprotectors can be correctly performed only by obtaining such curves. The dying out of stationary cell populations—bacteria, yeast, and mammalian cell cultures—also occurs in accordance with the Gompertz equation. In this regard, it is reasonable to use the construction of survival curves and their analysis to study the “aging” of non-subcultured cell cultures and testing anti-aging drugs on them. We used this approach in our experiments, due to which we were able to detect the positive anti-aging effect of the Quinton Marine Plasma on stationary phase aging culture of Chinese hamster cells.

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GOST |
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GOST Copy
Khokhlov A. N., Morgunova G. V., Klebanov A. A. Demographic Approaches to the Study of Aging on Cell Cultures // Moscow University Biological Sciences Bulletin. 2019. Vol. 74. No. 4. pp. 262-267.
GOST all authors (up to 50) Copy
Khokhlov A. N., Morgunova G. V., Klebanov A. A. Demographic Approaches to the Study of Aging on Cell Cultures // Moscow University Biological Sciences Bulletin. 2019. Vol. 74. No. 4. pp. 262-267.
RIS |
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RIS Copy
TY - JOUR
DO - 10.3103/S0096392519040060
UR - https://doi.org/10.3103%2FS0096392519040060
TI - Demographic Approaches to the Study of Aging on Cell Cultures
T2 - Moscow University Biological Sciences Bulletin
AU - Klebanov, A A
AU - Khokhlov, A N
AU - Morgunova, G V
PY - 2019
DA - 2019/10/01 00:00:00
PB - Pleiades Publishing
SP - 262-267
IS - 4
VL - 74
SN - 0096-3925
SN - 1934-791X
ER -
BibTex |
Cite this
BibTex Copy
@article{2019_Khokhlov
author = {A A Klebanov and A N Khokhlov and G V Morgunova},
title = {Demographic Approaches to the Study of Aging on Cell Cultures},
journal = {Moscow University Biological Sciences Bulletin},
year = {2019},
volume = {74},
publisher = {Pleiades Publishing},
month = {oct},
url = {https://doi.org/10.3103%2FS0096392519040060},
number = {4},
pages = {262--267},
doi = {10.3103/S0096392519040060}
}
MLA
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MLA Copy
Khokhlov, A. N., et al. “Demographic Approaches to the Study of Aging on Cell Cultures.” Moscow University Biological Sciences Bulletin, vol. 74, no. 4, Oct. 2019, pp. 262-267. https://doi.org/10.3103%2FS0096392519040060.
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