Bacterial test system for the primary screening of substances with potential antitumor activity
1
Institute of Molecular Biology and Genetics, National Academy of Sciences of Ukraine, Kiev, Ukraine
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Publication type: Journal Article
Publication date: 2007-08-14
scimago Q3
wos Q4
SJR: 0.184
CiteScore: 1.2
Impact factor: 0.5
ISSN: 00954527, 19349440
Cell Biology
Genetics
Agricultural and Biological Sciences (miscellaneous)
Abstract
A fundamental possibility of antitumor activity testing in the bacterial system represented by Escherichia coli of the wild type and its MS2-induced mutant has been shown. The initial bacterial strain is an indicator of toxic properties of tested substances and the mutant strain is a specific test culture modeling a tumor cell. The comparison of the data described for eukaryotes with the data obtained using the proposed bacterial test system confirms an adequate response of both strains to substances with proved antitumor properties. The data obtained are considered as very promising for the further improvement of this test system towards its application for primary screening of antitumor substances.
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Pererva T. P. et al. Bacterial test system for the primary screening of substances with potential antitumor activity // Cytology and Genetics. 2007. Vol. 41. No. 4. pp. 245-250.
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Pererva T. P., Dvornyk A. S., Miryuta A. Yu., Mozhylevska L. P., Kunakh V. A. Bacterial test system for the primary screening of substances with potential antitumor activity // Cytology and Genetics. 2007. Vol. 41. No. 4. pp. 245-250.
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RIS
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TY - JOUR
DO - 10.3103/s009545270704010x
UR - https://doi.org/10.3103/s009545270704010x
TI - Bacterial test system for the primary screening of substances with potential antitumor activity
T2 - Cytology and Genetics
AU - Pererva, T P
AU - Dvornyk, A S
AU - Miryuta, A Yu
AU - Mozhylevska, L P
AU - Kunakh, V. A.
PY - 2007
DA - 2007/08/14
PB - Pleiades Publishing
SP - 245-250
IS - 4
VL - 41
SN - 0095-4527
SN - 1934-9440
ER -
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BibTex (up to 50 authors)
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@article{2007_Pererva,
author = {T P Pererva and A S Dvornyk and A Yu Miryuta and L P Mozhylevska and V. A. Kunakh},
title = {Bacterial test system for the primary screening of substances with potential antitumor activity},
journal = {Cytology and Genetics},
year = {2007},
volume = {41},
publisher = {Pleiades Publishing},
month = {aug},
url = {https://doi.org/10.3103/s009545270704010x},
number = {4},
pages = {245--250},
doi = {10.3103/s009545270704010x}
}
Cite this
MLA
Copy
Pererva, T. P., et al. “Bacterial test system for the primary screening of substances with potential antitumor activity.” Cytology and Genetics, vol. 41, no. 4, Aug. 2007, pp. 245-250. https://doi.org/10.3103/s009545270704010x.