Open Access
Antimicrobial activities of some synthetic butenolides and their pyrrolone derivatives
1
Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Hamdard University, New Delhi, India
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Publication type: Journal Article
Publication date: 2009-12-23
scimago Q2
wos Q1
SJR: 0.857
CiteScore: 11.2
Impact factor: 5.4
ISSN: 14756366, 14756374
PubMed ID:
20030509
Drug Discovery
General Medicine
Pharmacology
Abstract
In the present investigation, 17 new synthetic butenolides, i.e. 2-arylidene-4-(4-chloro/ethyl-phenyl)but-3-en-4-olides (3–19) have been synthesized from 3-(4-chloro-benzoyl)propionic acid or 3-(4-ethyl-benzoyl)propionic acid using appropriate reagents. Some of the selected butenolides were reacted with ammonia and benzylamine to give the corresponding pyrrolones (20–31) and N-benzyl-pyrrolones (32–39) respectively. All the compounds were screened for their antibacterial activity against Staphylococcus aureus, Escherichia coli, and Pseudomonas aeruginosa and antifungal activity against Candida albicans, Aspergillus niger, and Rhizopus oryza. Minimum inhibitory concentration (MIC) values of the compounds are reported. The pyrrolone derivatives discovered in this study may provide valuable therapeutic intervention for the treatment of microbial diseases, especially against fungal species.
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Total citations:
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Citations from 2024:
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MLA
Cite this
GOST
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Husain A. et al. Antimicrobial activities of some synthetic butenolides and their pyrrolone derivatives // Journal of Enzyme Inhibition and Medicinal Chemistry. 2009. Vol. 25. No. 1. pp. 54-61.
GOST all authors (up to 50)
Copy
Husain A., Alam M. M., Shaharyar M., Lal S. Antimicrobial activities of some synthetic butenolides and their pyrrolone derivatives // Journal of Enzyme Inhibition and Medicinal Chemistry. 2009. Vol. 25. No. 1. pp. 54-61.
Cite this
RIS
Copy
TY - JOUR
DO - 10.3109/14756360902940860
UR - https://doi.org/10.3109/14756360902940860
TI - Antimicrobial activities of some synthetic butenolides and their pyrrolone derivatives
T2 - Journal of Enzyme Inhibition and Medicinal Chemistry
AU - Husain, Asif
AU - Alam, Mohammed Mumtaz
AU - Shaharyar, Mohammed
AU - Lal, Sukhbir
PY - 2009
DA - 2009/12/23
PB - Taylor & Francis
SP - 54-61
IS - 1
VL - 25
PMID - 20030509
SN - 1475-6366
SN - 1475-6374
ER -
Cite this
BibTex (up to 50 authors)
Copy
@article{2009_Husain,
author = {Asif Husain and Mohammed Mumtaz Alam and Mohammed Shaharyar and Sukhbir Lal},
title = {Antimicrobial activities of some synthetic butenolides and their pyrrolone derivatives},
journal = {Journal of Enzyme Inhibition and Medicinal Chemistry},
year = {2009},
volume = {25},
publisher = {Taylor & Francis},
month = {dec},
url = {https://doi.org/10.3109/14756360902940860},
number = {1},
pages = {54--61},
doi = {10.3109/14756360902940860}
}
Cite this
MLA
Copy
Husain, Asif, et al. “Antimicrobial activities of some synthetic butenolides and their pyrrolone derivatives.” Journal of Enzyme Inhibition and Medicinal Chemistry, vol. 25, no. 1, Dec. 2009, pp. 54-61. https://doi.org/10.3109/14756360902940860.