Acta Naturae, volume 14, issue 1, pages 40-53
Immunogenic Cell Death in Cancer Therapy
Publication type: Journal Article
Publication date: 2022-05-10
General Engineering
General Environmental Science
General Earth and Planetary Sciences
Abstract
Apoptosis plays a crucial role in chemotherapy-induced cell death. The conventional theory holding that apoptosis needs to be immunologically silent has recently been revised, and the concept of immunogenic cell death (ICD) has been proposed. This review describes the main features of ICD induction. These ICD markers are important for the effectiveness of anticancer therapy, as well as for basic research into cell death regulation. The mechanism of the vaccination effect of dying cancer cells undergoing ICD has been fully described, including the activation of specific antitumor response after re-challenge by the same living tumor cells. This review also discusses the whole set of molecular events attributing cell death to immunogenic type: the exposure of calreticulin and the heat shock protein HSP70 to the outer surface of the cell membrane and the release of the nuclear protein HMGB1 and ATP into the extracellular space. ICD inducers of various nature (chemotherapy drugs, cytotoxic proteins, and oncolytic viruses), as well as physical methods, are classified in the current review.
Citations by journals
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2
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Applied Biochemistry and Microbiology
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Applied Biochemistry and Microbiology
2 publications, 16.67%
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International Journal of Molecular Sciences
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International Journal of Molecular Sciences
1 publication, 8.33%
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1 publication, 8.33%
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1 publication, 8.33%
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Frontiers in Immunology
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Frontiers in Immunology
1 publication, 8.33%
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OncoImmunology
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OncoImmunology
1 publication, 8.33%
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Materials and Design
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1 publication, 8.33%
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Biomedicine and Pharmacotherapy
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Biomedicine and Pharmacotherapy
1 publication, 8.33%
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International Immunology
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International Immunology
1 publication, 8.33%
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Biomolecules
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Biomolecules
1 publication, 8.33%
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Acta Biomaterialia
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Acta Biomaterialia
1 publication, 8.33%
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1
2
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Citations by publishers
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Multidisciplinary Digital Publishing Institute (MDPI)
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Multidisciplinary Digital Publishing Institute (MDPI)
3 publications, 25%
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Elsevier
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Elsevier
3 publications, 25%
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Frontiers Media S.A.
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Frontiers Media S.A.
2 publications, 16.67%
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Pleiades Publishing
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Pleiades Publishing
2 publications, 16.67%
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Taylor & Francis
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Taylor & Francis
1 publication, 8.33%
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Oxford University Press
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Oxford University Press
1 publication, 8.33%
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3
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- We do not take into account publications that without a DOI.
- Statistics recalculated only for publications connected to researchers, organizations and labs registered on the platform.
- Statistics recalculated weekly.
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Troitskaya O.S. et al. Immunogenic Cell Death in Cancer Therapy // Acta Naturae. 2022. Vol. 14. No. 1. pp. 40-53.
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Troitskaya O.S., Novak D.D., Richter V.A., Koval O.A. Immunogenic Cell Death in Cancer Therapy // Acta Naturae. 2022. Vol. 14. No. 1. pp. 40-53.
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TY - JOUR
DO - 10.32607/actanaturae.11523
UR - https://doi.org/10.32607%2Factanaturae.11523
TI - Immunogenic Cell Death in Cancer Therapy
T2 - Acta Naturae
AU - Troitskaya, O S
AU - Novak, D D
AU - Richter, V A
AU - Koval, O A
PY - 2022
DA - 2022/05/10 00:00:00
PB - Acta Naturae Ltd
SP - 40-53
IS - 1
VL - 14
SN - 2075-8251
SN - 2075-8243
ER -
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@article{2022,
author = {O S Troitskaya and D D Novak and V A Richter and O A Koval},
title = {Immunogenic Cell Death in Cancer Therapy},
journal = {Acta Naturae},
year = {2022},
volume = {14},
publisher = {Acta Naturae Ltd},
month = {may},
url = {https://doi.org/10.32607%2Factanaturae.11523},
number = {1},
pages = {40--53},
doi = {10.32607/actanaturae.11523}
}
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