Open Access
Biointerface Research in Applied Chemistry, volume 12, issue 5, pages 6873-6894
Preparation and antitumor activity of betulin dipropionate and its composites
Publication type: Journal Article
Publication date: 2022-10-15
Quartile SCImago
Q3
Quartile WOS
—
Impact factor: —
ISSN: 20695837
Biochemistry
Molecular Biology
Molecular Medicine
Biotechnology
Abstract
Betulin dipropionate is a natural compound with high cytotoxicity toward many cancer cells. The one-step synthesis directly from the birch bark without a separate betulin isolation stage was developed to obtain betulin dipropionate. Due to its composition, betulin dipropionate is a promising drug for treating a wide range of diseases. However, the poor water solubility of this compound has limited its applications. We prepared the composites of betulin dipropionate using two methods: ball milling of the mixtures of betulin dipropionate with synthetic and natural polymers, such as polyvinylpyrrolidone polyethylene glycol, fumed silica, arabinogalactan, and preparation of thin films with arabinogalactan by evaporating the aqueous solutions. These composites showed higher water solubility and improved antitumor properties against ascites carcinoma cells and human lung adenocarcinoma cells compared with the initial substance. Furthermore, the cell viability studies based on Annexin V and Propidium iodide probes confirmed the high proapoptotic effect of betulin dipropionate against cancer cells.
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International Journal of Molecular Sciences
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International Journal of Molecular Sciences
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Multidisciplinary Digital Publishing Institute (MDPI)
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Multidisciplinary Digital Publishing Institute (MDPI)
1 publication, 100%
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Svetlana A. Kuznetsova et al. Preparation and antitumor activity of betulin dipropionate and its composites // Biointerface Research in Applied Chemistry. 2022. Vol. 12. No. 5. pp. 6873-6894.
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Svetlana A. Kuznetsova, Tatyana P. Shakhtshneider, Mikhail A. Mikhailenko, Yury N. Malyar, Anna S. Kichkailo 3., Valeri A. Drebushchak, Boris N. Kuznetsov Preparation and antitumor activity of betulin dipropionate and its composites // Biointerface Research in Applied Chemistry. 2022. Vol. 12. No. 5. pp. 6873-6894.
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TY - JOUR
DO - 10.33263/BRIAC125.68736894
UR - https://doi.org/10.33263%2FBRIAC125.68736894
TI - Preparation and antitumor activity of betulin dipropionate and its composites
T2 - Biointerface Research in Applied Chemistry
AU - Svetlana, A
AU - Tatyana, P
AU - Mikhail, A
AU - Yury, N
AU - Anna, S
AU - Valeri, A
AU - Boris, N
PY - 2022
DA - 2022/10/15 00:00:00
PB - AMG Transcend Association
SP - 6873-6894
IS - 5
VL - 12
SN - 2069-5837
ER -
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@article{2022,
author = {A Svetlana and P Tatyana and A Mikhail and N Yury and S Anna and A Valeri and N Boris},
title = {Preparation and antitumor activity of betulin dipropionate and its composites},
journal = {Biointerface Research in Applied Chemistry},
year = {2022},
volume = {12},
publisher = {AMG Transcend Association},
month = {oct},
url = {https://doi.org/10.33263%2FBRIAC125.68736894},
number = {5},
pages = {6873--6894},
doi = {10.33263/BRIAC125.68736894}
}