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Drug development & registration, volume 10, issue 4, pages 81-88

Development of the Composition and Technology for Obtaining Paclitaxel Nanoscale Formulation Consisting of a Conjugate of Polymer Particles with a Protein Vector Molecule

Publication type: Journal Article
Publication date: 2021-11-25
Quartile SCImago
Q3
Quartile WOS
—
Impact factor: —
ISSN: 23052066, 26585049
Drug Discovery
Pharmaceutical Science
Abstract

Introduction. The use of the anticancer drug paclitaxel is limited due to its high toxicity and lipophilicity. A new polymer composition of paclitaxel has been proposed, which provides targeted transport of the drug into tumor cells and improves its safety.

Aim. Method development for preparation of a novel paclitaxel formulation consisting of a conjugate of PLGA nanoparticles with the third domain of alpha-fetoprotein.

Materials and methods. The object of this study is paclitaxel-loaded nanoparticles based on a copolymer of lactic and glycolic acids, the surface of which is modified with a vector molecule - the recombinant third domain of alpha-fetoprotein. Nanoparticles were obtained by single emulsification method and precipitation. Conjugation with a protein molecule was performed by the carbodiimide method. The analysis of the obtained nanoparticles was carried out using dynamic and electrophoretic light scattering, high performance liquid chromatography, dialysis membrane method.

Results and discussion. Synthesis of paclitaxel-loaded nanoparticles based on a copolymer of lactic and glycolic acids and its conjugation optimization under varying a wide range of conditions have been carried out. The resulting conjugate had an average diameter of 280 ± 12 nm. The conjugation efficiency was 95 %. The release of paclitaxel from the polymer matrix in the release medium was 65 % in 220 h.

Conclusions. A method of obtaining and substantiating the composition of the original nanosized form of paclitaxel is proposed. The possibility of prolonged release of paclitaxel from the polymer matrix has been shown.

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International Journal of Molecular Sciences
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Multidisciplinary Digital Publishing Institute (MDPI)
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Sokol M. B. et al. Development of the Composition and Technology for Obtaining Paclitaxel Nanoscale Formulation Consisting of a Conjugate of Polymer Particles with a Protein Vector Molecule // Drug development & registration. 2021. Vol. 10. No. 4. pp. 81-88.
GOST all authors (up to 50) Copy
Sokol M. B., Yabbarov N. G., Mollaeva M. R., Chirkina M. V., Balabanyan V. Yu., Nikolskaya E. D. Development of the Composition and Technology for Obtaining Paclitaxel Nanoscale Formulation Consisting of a Conjugate of Polymer Particles with a Protein Vector Molecule // Drug development & registration. 2021. Vol. 10. No. 4. pp. 81-88.
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RIS Copy
TY - JOUR
DO - 10.33380/2305-2066-2021-10-4-81-88
UR - https://doi.org/10.33380%2F2305-2066-2021-10-4-81-88
TI - Development of the Composition and Technology for Obtaining Paclitaxel Nanoscale Formulation Consisting of a Conjugate of Polymer Particles with a Protein Vector Molecule
T2 - Drug development & registration
AU - Sokol, Mariya B
AU - Yabbarov, Nikita G
AU - Mollaeva, Mariia R
AU - Chirkina, Margarita V
AU - Balabanyan, V Yu
AU - Nikolskaya, Elena D
PY - 2021
DA - 2021/11/25 00:00:00
PB - Center of Pharmaceutical Analytics Ltd
SP - 81-88
IS - 4
VL - 10
SN - 2305-2066
SN - 2658-5049
ER -
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@article{2021_Sokol,
author = {Mariya B Sokol and Nikita G Yabbarov and Mariia R Mollaeva and Margarita V Chirkina and V Yu Balabanyan and Elena D Nikolskaya},
title = {Development of the Composition and Technology for Obtaining Paclitaxel Nanoscale Formulation Consisting of a Conjugate of Polymer Particles with a Protein Vector Molecule},
journal = {Drug development & registration},
year = {2021},
volume = {10},
publisher = {Center of Pharmaceutical Analytics Ltd},
month = {nov},
url = {https://doi.org/10.33380%2F2305-2066-2021-10-4-81-88},
number = {4},
pages = {81--88},
doi = {10.33380/2305-2066-2021-10-4-81-88}
}
MLA
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Sokol, Mariya B., et al. “Development of the Composition and Technology for Obtaining Paclitaxel Nanoscale Formulation Consisting of a Conjugate of Polymer Particles with a Protein Vector Molecule.” Drug development & registration, vol. 10, no. 4, Nov. 2021, pp. 81-88. https://doi.org/10.33380%2F2305-2066-2021-10-4-81-88.
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