Aquatic Microbial Ecology, volume 84, issue 1, pages 1-14
Freshwater Actinobacteria from sediments of the deep and ancient Lake Baikal (Russia) and their genetic potential as producers of secondary metabolites
Publication type: Journal Article
Publication date: 2020-01-16
Journal:
Aquatic Microbial Ecology
Quartile SCImago
Q3
Quartile WOS
Q3
Impact factor: 1.4
ISSN: 09483055, 16161564
DOI:
10.3354/ame01923
Ecology, Evolution, Behavior and Systematics
Aquatic Science
Abstract
Actinobacteria from terrestrial and marine environments produce a variety of natural products that mediate interand intraspecies interactions. In contrast, the potential of freshwater Actinobacteria for secondary metabolite production remains underexplored. Large lakes with a long evolutionary history might contain microflora subjected to unique environmental conditions that favor the evolution of unique metabolic capabilities. One such lake is Lake Baikal (Russia), the deepest lake on earth as well as one of the oldest. In this study, we investigated the genetically encoded secondary metabolic potential of 24 Actinobacteria strains isolated from Lake Baikal sediments. PCR-based screening for genes encoding type I and type II polyketide synthases (PKSs), nonribosomal peptide synthetases (NRPSs), and halogenases confirmed that all strains possessed at least 1 of these biosynthetic genes. Both PKSs and NRPSs were widely distributed, while halogenase-encoding genes were not detected. Phylogenetic comparison of type I PKS ketosynthase (KS) domain sequences between freshwater isolates and marine and terrestrial strains supported overlap between KSs from these 3 groups. Evaluation of antibiotic activity for chemical extracts from all isolates revealed that 75% produced metabolites inhibitory toward model bacteria and/or fungi. To our knowledge, this study is among the first evaluations of the genetically encoded secondary metabolic capabilities of freshwater sediment Actinobacteria. Our findings highlight the similarities and differences between freshwater and marine Actinobacteria secondary metabolism, suggesting the potential of freshwater Actinobacteria for the production of natural products that may play roles as mediators of interactions between organisms in freshwater habitats.
Citations by journals
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1
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Wiley Interdisciplinary Reviews Water
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Wiley Interdisciplinary Reviews Water
1 publication, 50%
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Biocontrol Science and Technology
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Biocontrol Science and Technology
1 publication, 50%
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1
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Citations by publishers
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1
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Wiley
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Wiley
1 publication, 50%
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Taylor & Francis
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Taylor & Francis
1 publication, 50%
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1
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Protasov E. et al. Freshwater Actinobacteria from sediments of the deep and ancient Lake Baikal (Russia) and their genetic potential as producers of secondary metabolites // Aquatic Microbial Ecology. 2020. Vol. 84. No. 1. pp. 1-14.
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Protasov E., Axenov Gribanov D., Axenov-Gribanov D., Shatilina Z., Timofeyev M., Lane A. Freshwater Actinobacteria from sediments of the deep and ancient Lake Baikal (Russia) and their genetic potential as producers of secondary metabolites // Aquatic Microbial Ecology. 2020. Vol. 84. No. 1. pp. 1-14.
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TY - JOUR
DO - 10.3354/ame01923
UR - https://doi.org/10.3354%2Fame01923
TI - Freshwater Actinobacteria from sediments of the deep and ancient Lake Baikal (Russia) and their genetic potential as producers of secondary metabolites
T2 - Aquatic Microbial Ecology
AU - Protasov, Es
AU - Axenov Gribanov, Dv
AU - Shatilina, Zm
AU - Timofeyev, Ma
AU - Lane, Al
AU - Axenov-Gribanov, DV
PY - 2020
DA - 2020/01/16 00:00:00
PB - Inter-Research Science Center
SP - 1-14
IS - 1
VL - 84
SN - 0948-3055
SN - 1616-1564
ER -
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BibTex
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@article{2020_Protasov,
author = {Es Protasov and Dv Axenov Gribanov and Zm Shatilina and Ma Timofeyev and Al Lane and DV Axenov-Gribanov},
title = {Freshwater Actinobacteria from sediments of the deep and ancient Lake Baikal (Russia) and their genetic potential as producers of secondary metabolites},
journal = {Aquatic Microbial Ecology},
year = {2020},
volume = {84},
publisher = {Inter-Research Science Center},
month = {jan},
url = {https://doi.org/10.3354%2Fame01923},
number = {1},
pages = {1--14},
doi = {10.3354/ame01923}
}
Cite this
MLA
Copy
Protasov, Es, et al. “Freshwater Actinobacteria from sediments of the deep and ancient Lake Baikal (Russia) and their genetic potential as producers of secondary metabolites.” Aquatic Microbial Ecology, vol. 84, no. 1, Jan. 2020, pp. 1-14. https://doi.org/10.3354%2Fame01923.
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