Open Access
Frontiers in Cell and Developmental Biology, volume 8
Hox-Positive Adult Mesenchymal Stromal Cells: Beyond Positional Identity
Kulebyakina Maria
1
,
Makarevich Pavel
1, 2
Publication type: Journal Article
Publication date: 2020-07-31
Quartile SCImago
Q1
Quartile WOS
Q1
Impact factor: 5.5
ISSN: 2296634X
Cell Biology
Developmental Biology
Abstract
Homeobox proteins (Hox) are universal regulators of body patterning process in embryogenesis of metazoan. The Hox gene expression pattern (Hox code) retains in adult tissues and serves as cellular positional identity marker. Despite previously existing notions that the Hox code is inherent in all stroma mesenchymal cells as a whole, recent studies have shown that the Hox code may be an attribute of a distinct subpopulation of adult resident mesenchymal stromal cells (MSC). Recent evidence allows to suggest a “non-canonical” role for Hox genes expression which is associated with renewal and regeneration in postnatal organs after damage. In tissues with high regenerative capacity it has been shown that a special cell population is critical for these processes, a distinctive feature of which is persistent expression of tissue-specific Hox genes. We believe that in the postnatal period Hox-positive subpopulation of resident MSC may function as a unique regenerative reserve. These cells coordinate creation and maintenance of correct structure of the stroma through a tissue-specific combination of mechanisms. In this article, we summarize the data on the role of resident mesenchymal stromal cells that have a tissue-specific pattern of Hox gene expression as regulators of processes necessary for correct reconstruction of the tissue.
Citations by journals
|
1
|
|
|
Stem Cells and Development
|
Stem Cells and Development
1 publication, 14.29%
|
|
Frontiers in Cell and Developmental Biology
|
Frontiers in Cell and Developmental Biology
1 publication, 14.29%
|
|
Biology
|
Biology
1 publication, 14.29%
|
|
Genomics
|
Genomics
1 publication, 14.29%
|
|
Heliyon
|
Heliyon
1 publication, 14.29%
|
|
Developmental Biology
|
Developmental Biology
1 publication, 14.29%
|
|
1
|
Citations by publishers
|
1
2
3
|
|
|
Elsevier
|
Elsevier
3 publications, 42.86%
|
|
Mary Ann Liebert
|
Mary Ann Liebert
1 publication, 14.29%
|
|
Frontiers Media S.A.
|
Frontiers Media S.A.
1 publication, 14.29%
|
|
Multidisciplinary Digital Publishing Institute (MDPI)
|
Multidisciplinary Digital Publishing Institute (MDPI)
1 publication, 14.29%
|
|
1
2
3
|
- We do not take into account publications that without a DOI.
- Statistics recalculated only for publications connected to researchers, organizations and labs registered on the platform.
- Statistics recalculated weekly.
{"yearsCitations":{"type":"bar","data":{"show":true,"labels":[2021,2022,2023],"ids":[0,0,0],"codes":[0,0,0],"imageUrls":["","",""],"datasets":[{"label":"Citations number","data":[1,3,3],"backgroundColor":["#3B82F6","#3B82F6","#3B82F6"],"percentage":["14.29","42.86","42.86"],"barThickness":null}]},"options":{"indexAxis":"x","maintainAspectRatio":true,"scales":{"y":{"ticks":{"precision":0,"autoSkip":false,"font":{"family":"Montserrat"},"color":"#000000"}},"x":{"ticks":{"stepSize":1,"precision":0,"font":{"family":"Montserrat"},"color":"#000000"}}},"plugins":{"legend":{"position":"top","labels":{"font":{"family":"Montserrat"},"color":"#000000"}},"title":{"display":true,"text":"Citations per year","font":{"size":24,"family":"Montserrat","weight":600},"color":"#000000"}}}},"journals":{"type":"bar","data":{"show":true,"labels":["Stem Cells and Development","Frontiers in Cell and Developmental Biology","Biology","Genomics","Heliyon","Developmental Biology"],"ids":[16303,12128,24144,7590,21848,3763],"codes":[0,0,0,0,0,0],"imageUrls":["\/storage\/images\/resized\/Zy5YST233rzRbZP24I24MzZm64hz20ZV9qQopmMn_medium.webp","\/storage\/images\/resized\/4QWA67eqfcfyOiA8Wk7YnqroHFqQbTsmDJUYTCTg_medium.webp","\/storage\/images\/resized\/MjH1ITP7lMYGxeqUZfkt2BnVLgjkk413jwBV97XX_medium.webp","\/storage\/images\/resized\/GDnYOu1UpMMfMMRV6Aqle4H0YLLsraeD9IP9qScG_medium.webp","\/storage\/images\/resized\/GDnYOu1UpMMfMMRV6Aqle4H0YLLsraeD9IP9qScG_medium.webp","\/storage\/images\/resized\/GDnYOu1UpMMfMMRV6Aqle4H0YLLsraeD9IP9qScG_medium.webp"],"datasets":[{"label":"","data":[1,1,1,1,1,1],"backgroundColor":["#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6"],"percentage":[14.29,14.29,14.29,14.29,14.29,14.29],"barThickness":13}]},"options":{"indexAxis":"y","maintainAspectRatio":false,"scales":{"y":{"ticks":{"precision":0,"autoSkip":false,"font":{"family":"Montserrat"},"color":"#000000"}},"x":{"ticks":{"stepSize":null,"precision":0,"font":{"family":"Montserrat"},"color":"#000000"}}},"plugins":{"legend":{"position":"top","labels":{"font":{"family":"Montserrat"},"color":"#000000"}},"title":{"display":true,"text":"Journals","font":{"size":24,"family":"Montserrat","weight":600},"color":"#000000"}}}},"publishers":{"type":"bar","data":{"show":true,"labels":["Elsevier","Mary Ann Liebert","Frontiers Media S.A.","Multidisciplinary Digital Publishing Institute (MDPI)"],"ids":[17,230,208,202],"codes":[0,0,0,0],"imageUrls":["\/storage\/images\/resized\/GDnYOu1UpMMfMMRV6Aqle4H0YLLsraeD9IP9qScG_medium.webp","\/storage\/images\/resized\/Zy5YST233rzRbZP24I24MzZm64hz20ZV9qQopmMn_medium.webp","\/storage\/images\/resized\/4QWA67eqfcfyOiA8Wk7YnqroHFqQbTsmDJUYTCTg_medium.webp","\/storage\/images\/resized\/MjH1ITP7lMYGxeqUZfkt2BnVLgjkk413jwBV97XX_medium.webp"],"datasets":[{"label":"","data":[3,1,1,1],"backgroundColor":["#3B82F6","#3B82F6","#3B82F6","#3B82F6"],"percentage":[42.86,14.29,14.29,14.29],"barThickness":13}]},"options":{"indexAxis":"y","maintainAspectRatio":false,"scales":{"y":{"ticks":{"precision":0,"autoSkip":false,"font":{"family":"Montserrat"},"color":"#000000"}},"x":{"ticks":{"stepSize":null,"precision":0,"font":{"family":"Montserrat"},"color":"#000000"}}},"plugins":{"legend":{"position":"top","labels":{"font":{"family":"Montserrat"},"color":"#000000"}},"title":{"display":true,"text":"Publishers","font":{"size":24,"family":"Montserrat","weight":600},"color":"#000000"}}}}}
Metrics
Cite this
GOST |
RIS |
BibTex
Cite this
GOST
Copy
Kulebyakina M., Makarevich P. Hox-Positive Adult Mesenchymal Stromal Cells: Beyond Positional Identity // Frontiers in Cell and Developmental Biology. 2020. Vol. 8.
GOST all authors (up to 50)
Copy
Kulebyakina M., Makarevich P. Hox-Positive Adult Mesenchymal Stromal Cells: Beyond Positional Identity // Frontiers in Cell and Developmental Biology. 2020. Vol. 8.
Cite this
RIS
Copy
TY - JOUR
DO - 10.3389/fcell.2020.00624
UR - https://doi.org/10.3389%2Ffcell.2020.00624
TI - Hox-Positive Adult Mesenchymal Stromal Cells: Beyond Positional Identity
T2 - Frontiers in Cell and Developmental Biology
AU - Kulebyakina, Maria
AU - Makarevich, Pavel
PY - 2020
DA - 2020/07/31 00:00:00
PB - Frontiers Media S.A.
VL - 8
SN - 2296-634X
ER -
Cite this
BibTex
Copy
@article{2020_Kulebyakina,
author = {Maria Kulebyakina and Pavel Makarevich},
title = {Hox-Positive Adult Mesenchymal Stromal Cells: Beyond Positional Identity},
journal = {Frontiers in Cell and Developmental Biology},
year = {2020},
volume = {8},
publisher = {Frontiers Media S.A.},
month = {jul},
url = {https://doi.org/10.3389%2Ffcell.2020.00624},
doi = {10.3389/fcell.2020.00624}
}
Profiles