Open Access
Frontiers in Cell and Developmental Biology, volume 9
Scar-Free Healing of Endometrium: Tissue-Specific Program of Stromal Cells and Its Induction by Soluble Factors Produced After Damage
Eremichev Roman
1
,
Kulebyakina Maria
2
,
Alexandrushkina Nataliya
1, 2
,
Nimiritsky Peter
1, 2
,
Basalova Nataliya
1, 2
,
Grigorieva Olga
1
,
Egiazaryan Mane
2
,
Dyikanov Daniyar
2
,
Tkachuk Vsevolod
1, 2, 3
,
Makarevich Pavel
1, 2
Publication type: Journal Article
Publication date: 2021-02-25
Quartile SCImago
Q1
Quartile WOS
Q1
Impact factor: 5.5
ISSN: 2296634X
Cell Biology
Developmental Biology
Abstract
Besides certain exceptions, healing of most tissues in the human body occurs via formation of scar tissue, rather than restoration of lost structures. After extensive acute injuries, this phenomenon substantially limits the possibility of lost function recovery and, in case of chronic injury, it leads to pathological remodeling of organs affected. Managing outcomes of damaged tissue repair is one of the main objectives of regenerative medicine. The first priority for reaching it is comparative investigation of mechanisms responsible for complete restoration of damaged tissues and mechanisms of scarring. However, human body tissues that undergo complete scar-free healing are scarce. The endometrium is a unique mucous membrane in the human body that heals without scarring after various injuries, as well as during each menstrual cycle (i.e., up to 400 times during a woman’s life). We hypothesized that absence of scarring during endometrial healing may be associated with tissue-specific features of its stromal cells (SCs) or their microenvironment, since SCs transform into myofibroblasts—the main effector link of scarring. We found that during healing of the endometrium, soluble factors are formed that inhibit the transition of SCs into myofibroblasts. Without influence of these factors, the SCs of the endometrium undergo transformation into myofibroblasts after transforming growth factor β1 (TGF-β1) treatment as well as the SCs from tissues that heal by scarring—skin or fat. However, unlike the latter, endometrial SCs organize extracellular matrix (ECM) in a specific way and are not prone to formation of bulky connective tissue structures. Thus, we may suggest that tissue-specific features of endometrial SCs along with effects of soluble factors secreted in utero during menstruation ensure scar-free healing of human endometrium.
Citations by journals
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1
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3
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International Journal of Molecular Sciences
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International Journal of Molecular Sciences
3 publications, 20%
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Biomedicines
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Biomedicines
2 publications, 13.33%
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Russian Bulletin of Obstetrician-Gynecologist / Rossiyskii Vestnik Akushera-Ginekologa
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Russian Bulletin of Obstetrician-Gynecologist / Rossiyskii Vestnik Akushera-Ginekologa
2 publications, 13.33%
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Frontiers in Reproductive Health
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Frontiers in Reproductive Health
1 publication, 6.67%
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Genes and Diseases
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Genes and Diseases
1 publication, 6.67%
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Regenerative Biomaterials
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Regenerative Biomaterials
1 publication, 6.67%
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Biomolecules
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Biomolecules
1 publication, 6.67%
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Frontiers in Endocrinology
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Frontiers in Endocrinology
1 publication, 6.67%
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Genes
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Genes
1 publication, 6.67%
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1
2
3
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Citations by publishers
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1
2
3
4
5
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7
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Multidisciplinary Digital Publishing Institute (MDPI)
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Multidisciplinary Digital Publishing Institute (MDPI)
7 publications, 46.67%
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Frontiers Media S.A.
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Frontiers Media S.A.
2 publications, 13.33%
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Media Sphere Publishing Group
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Media Sphere Publishing Group
2 publications, 13.33%
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Elsevier
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Elsevier
1 publication, 6.67%
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Oxford University Press
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Oxford University Press
1 publication, 6.67%
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1
2
3
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7
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- We do not take into account publications that without a DOI.
- Statistics recalculated only for publications connected to researchers, organizations and labs registered on the platform.
- Statistics recalculated weekly.
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Eremichev R. et al. Scar-Free Healing of Endometrium: Tissue-Specific Program of Stromal Cells and Its Induction by Soluble Factors Produced After Damage // Frontiers in Cell and Developmental Biology. 2021. Vol. 9.
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Eremichev R., Kulebyakina M., Alexandrushkina N., Nimiritsky P., Basalova N., Grigorieva O., Egiazaryan M., Dyikanov D., Tkachuk V., Makarevich P. Scar-Free Healing of Endometrium: Tissue-Specific Program of Stromal Cells and Its Induction by Soluble Factors Produced After Damage // Frontiers in Cell and Developmental Biology. 2021. Vol. 9.
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TY - JOUR
DO - 10.3389/fcell.2021.616893
UR - https://doi.org/10.3389%2Ffcell.2021.616893
TI - Scar-Free Healing of Endometrium: Tissue-Specific Program of Stromal Cells and Its Induction by Soluble Factors Produced After Damage
T2 - Frontiers in Cell and Developmental Biology
AU - Eremichev, Roman
AU - Kulebyakina, Maria
AU - Alexandrushkina, Nataliya
AU - Nimiritsky, Peter
AU - Basalova, Nataliya
AU - Grigorieva, Olga
AU - Egiazaryan, Mane
AU - Dyikanov, Daniyar
AU - Tkachuk, Vsevolod
AU - Makarevich, Pavel
PY - 2021
DA - 2021/02/25 00:00:00
PB - Frontiers Media S.A.
VL - 9
SN - 2296-634X
ER -
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@article{2021_Eremichev,
author = {Roman Eremichev and Maria Kulebyakina and Nataliya Alexandrushkina and Peter Nimiritsky and Nataliya Basalova and Olga Grigorieva and Mane Egiazaryan and Daniyar Dyikanov and Vsevolod Tkachuk and Pavel Makarevich},
title = {Scar-Free Healing of Endometrium: Tissue-Specific Program of Stromal Cells and Its Induction by Soluble Factors Produced After Damage},
journal = {Frontiers in Cell and Developmental Biology},
year = {2021},
volume = {9},
publisher = {Frontiers Media S.A.},
month = {feb},
url = {https://doi.org/10.3389%2Ffcell.2021.616893},
doi = {10.3389/fcell.2021.616893}
}