Open Access
Frontiers in Immunology, volume 13
Memory B Cells Induced by Sputnik V Vaccination Produce SARS-CoV-2 Neutralizing Antibodies Upon Ex Vivo Restimulation
Byazrova Maria G
1, 2
,
Kulemzin Sergey V
3
,
Astakhova Ekaterina A
1, 2
,
Belovezhets Tatyana N
3
,
Efimov Grigory A.
4
,
Chikaev Anton N
3
,
Kolotygin Ilya O
3
,
Gorchakov Andrey A
3
,
Taranin Alexander V
3
,
Filatov Alexander V
1, 2
Publication type: Journal Article
Publication date: 2022-02-24
Journal:
Frontiers in Immunology
Quartile SCImago
Q1
Quartile WOS
Q1
Impact factor: 7.3
ISSN: 16643224
PubMed ID:
35280987
Immunology
Immunology and Allergy
Abstract
The development of effective vaccines against SARS-CoV-2 remains a global health priority. Despite extensive use, the effects of Sputnik V on B cell immunity need to be explored in detail. We performed comprehensive profiling of humoral and B cell responses in a cohort of vaccinated subjects (n = 22), and demonstrate that Sputnik vaccination results in robust B cell immunity.
We show that B memory cell (MBC) and antibody responses to Sputnik V were heavily dependent on whether the vaccinee had a history of SARS-CoV-2 infection or not. 85 days after the first dose of the vaccine, ex vivo stimulated MBCs from the vast majority of Sputnik V vaccinees produced antibodies that robustly neutralized the Wuhan Spike-pseudotyped lentivirus. MBC-derived antibodies from all previously infected and some of the naïve vaccine recipients could also cross-neutralize Beta (B.1.351) variant of SARS-CoV-2.
Virus-neutralizing activity of MBC-derived antibodies correlated well with that of the serum antibodies, suggesting the interplay between the MBC and long-lived plasma cell responses. Thus, our in-depth analysis of MBC responses in Sputnik V vaccinees complements traditional serological approaches and may provide important outlook into future B cell responses upon re-encounter with the emerging variants of SARS-CoV-2.
Citations by journals
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1
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3
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Vaccines
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Vaccines
3 publications, 27.27%
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International Journal of Molecular Sciences
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International Journal of Molecular Sciences
2 publications, 18.18%
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Communications Biology
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Communications Biology
1 publication, 9.09%
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Cells
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Cells
1 publication, 9.09%
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npj Vaccines
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npj Vaccines
1 publication, 9.09%
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Medical Immunology (Russia)
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Medical Immunology (Russia), 1, 9.09%
Medical Immunology (Russia)
1 publication, 9.09%
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Microorganisms
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Microorganisms
1 publication, 9.09%
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Scandinavian Journal of Immunology
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Scandinavian Journal of Immunology
1 publication, 9.09%
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1
2
3
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Citations by publishers
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1
2
3
4
5
6
7
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Multidisciplinary Digital Publishing Institute (MDPI)
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Multidisciplinary Digital Publishing Institute (MDPI)
7 publications, 63.64%
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Springer Nature
|
Springer Nature
2 publications, 18.18%
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Russian Association of Allergologists and Clinical Immunologists, St. Petersburg Regional Branch (SPb RAACI)
|
Russian Association of Allergologists and Clinical Immunologists, St. Petersburg Regional Branch (SPb RAACI), 1, 9.09%
Russian Association of Allergologists and Clinical Immunologists, St. Petersburg Regional Branch (SPb RAACI)
1 publication, 9.09%
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Wiley
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Wiley
1 publication, 9.09%
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1
2
3
4
5
6
7
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- We do not take into account publications that without a DOI.
- Statistics recalculated only for publications connected to researchers, organizations and labs registered on the platform.
- Statistics recalculated weekly.
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Byazrova M. G. et al. Memory B Cells Induced by Sputnik V Vaccination Produce SARS-CoV-2 Neutralizing Antibodies Upon Ex Vivo Restimulation // Frontiers in Immunology. 2022. Vol. 13.
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Byazrova M. G., Kulemzin S. V., Astakhova E. A., Belovezhets T. N., Efimov G. A., Chikaev A. N., Kolotygin I. O., Gorchakov A. A., Taranin A. V., Filatov A. V. Memory B Cells Induced by Sputnik V Vaccination Produce SARS-CoV-2 Neutralizing Antibodies Upon Ex Vivo Restimulation // Frontiers in Immunology. 2022. Vol. 13.
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TY - JOUR
DO - 10.3389/fimmu.2022.840707
UR - https://doi.org/10.3389%2Ffimmu.2022.840707
TI - Memory B Cells Induced by Sputnik V Vaccination Produce SARS-CoV-2 Neutralizing Antibodies Upon Ex Vivo Restimulation
T2 - Frontiers in Immunology
AU - Byazrova, Maria G
AU - Kulemzin, Sergey V
AU - Astakhova, Ekaterina A
AU - Belovezhets, Tatyana N
AU - Efimov, Grigory A.
AU - Chikaev, Anton N
AU - Kolotygin, Ilya O
AU - Gorchakov, Andrey A
AU - Taranin, Alexander V
AU - Filatov, Alexander V
PY - 2022
DA - 2022/02/24 00:00:00
PB - Frontiers Media S.A.
VL - 13
PMID - 35280987
SN - 1664-3224
ER -
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@article{2022_Byazrova,
author = {Maria G Byazrova and Sergey V Kulemzin and Ekaterina A Astakhova and Tatyana N Belovezhets and Grigory A. Efimov and Anton N Chikaev and Ilya O Kolotygin and Andrey A Gorchakov and Alexander V Taranin and Alexander V Filatov},
title = {Memory B Cells Induced by Sputnik V Vaccination Produce SARS-CoV-2 Neutralizing Antibodies Upon Ex Vivo Restimulation},
journal = {Frontiers in Immunology},
year = {2022},
volume = {13},
publisher = {Frontiers Media S.A.},
month = {feb},
url = {https://doi.org/10.3389%2Ffimmu.2022.840707},
doi = {10.3389/fimmu.2022.840707}
}