Open Access
Frontiers in Microbiology, volume 11
Propionate Induces Virulent Properties of Crohn’s Disease-Associated Escherichia coli
Publication type: Journal Article
Publication date: 2020-07-08
Journal:
Frontiers in Microbiology
Quartile SCImago
Q1
Quartile WOS
Q2
Impact factor: 5.2
ISSN: 1664302X
Microbiology (medical)
Microbiology
Abstract
Crohn’s disease (CD) is a severe chronic immune-mediated granulomatous inflammatory disease of the gastrointestinal tract. The mechanisms of CD pathogenesis remain obscure. Metagenomic analysis of samples from CD patients revealed that several of them have the elevated level of Escherichia coli with adhesive-invasive phenotype (AIEC). Previously we isolated an E. coli strain CD isolate ZvL2 from a patient with CD, which features AIEC phenotype. Here we demonstrate that prolonged growth on propionate containing medium stimulates virulent properties of CD isolate ZvL2, while prolonged growth on glucose reduces these properties to levels indistinguishable from laboratory strain K-12 MG1655. Propionate presence also boosts the ability of CD isolate ZvL2 to penetrate and colonize macrophages. The effect of propionate is reversible, re-passaging of CD-isolate on M9 medium supplemented with glucose leads to the loss of its virulent properties. Proteome analysis of CD isolate ZvL2 growth in medium supplemented with propionate or glucose revealed that propionate induces expression porins OmpA and OmpW, transcription factors PhoP, OmpR and universal stress protein UspE, which were previously found to be important for macrophage colonization by enteropathogenic bacteria.
Citations by journals
|
1
2
|
|
|
Bulletin of Experimental Biology and Medicine
|
Bulletin of Experimental Biology and Medicine
2 publications, 16.67%
|
|
Gut Microbes
|
Gut Microbes
1 publication, 8.33%
|
|
Frontiers in Molecular Biosciences
|
Frontiers in Molecular Biosciences
1 publication, 8.33%
|
|
Frontiers in Microbiology
|
Frontiers in Microbiology
1 publication, 8.33%
|
|
Biomedicine and Pharmacotherapy
|
Biomedicine and Pharmacotherapy
1 publication, 8.33%
|
|
Infection and Immunity
|
Infection and Immunity
1 publication, 8.33%
|
|
EcoSal Plus
|
EcoSal Plus
1 publication, 8.33%
|
|
Journal of Bioenergetics and Biomembranes
|
Journal of Bioenergetics and Biomembranes
1 publication, 8.33%
|
|
Cellular Signalling
|
Cellular Signalling
1 publication, 8.33%
|
|
Journal of Fungi
|
Journal of Fungi
1 publication, 8.33%
|
|
1
2
|
Citations by publishers
|
1
2
3
|
|
|
Springer Nature
|
Springer Nature
3 publications, 25%
|
|
Frontiers Media S.A.
|
Frontiers Media S.A.
2 publications, 16.67%
|
|
Elsevier
|
Elsevier
2 publications, 16.67%
|
|
American Society for Microbiology
|
American Society for Microbiology
2 publications, 16.67%
|
|
Taylor & Francis
|
Taylor & Francis
1 publication, 8.33%
|
|
Multidisciplinary Digital Publishing Institute (MDPI)
|
Multidisciplinary Digital Publishing Institute (MDPI)
1 publication, 8.33%
|
|
1
2
3
|
- We do not take into account publications that without a DOI.
- Statistics recalculated only for publications connected to researchers, organizations and labs registered on the platform.
- Statistics recalculated weekly.
{"yearsCitations":{"type":"bar","data":{"show":true,"labels":[2021,2022,2023,2024],"ids":[0,0,0,0],"codes":[0,0,0,0],"imageUrls":["","","",""],"datasets":[{"label":"Citations number","data":[3,3,3,3],"backgroundColor":["#3B82F6","#3B82F6","#3B82F6","#3B82F6"],"percentage":["25","25","25","25"],"barThickness":null}]},"options":{"indexAxis":"x","maintainAspectRatio":true,"scales":{"y":{"ticks":{"precision":0,"autoSkip":false,"font":{"family":"Montserrat"},"color":"#000000"}},"x":{"ticks":{"stepSize":1,"precision":0,"font":{"family":"Montserrat"},"color":"#000000"}}},"plugins":{"legend":{"position":"top","labels":{"font":{"family":"Montserrat"},"color":"#000000"}},"title":{"display":true,"text":"Citations per year","font":{"size":24,"family":"Montserrat","weight":600},"color":"#000000"}}}},"journals":{"type":"bar","data":{"show":true,"labels":["Bulletin of Experimental Biology and Medicine","Gut Microbes","Frontiers in Molecular Biosciences","Frontiers in Microbiology","Biomedicine and Pharmacotherapy","Infection and Immunity","EcoSal Plus","Journal of Bioenergetics and Biomembranes","Cellular Signalling","Journal of Fungi"],"ids":[7563,14022,3133,24403,23951,20866,12012,16422,5839,3021],"codes":[0,0,0,0,0,0,0,0,0,0],"imageUrls":["\/storage\/images\/resized\/voXLqlsvTwv5p3iMQ8Dhs95nqB4AXOG7Taj7G4ra_medium.webp","\/storage\/images\/resized\/5YZtvLvkPZuc2JHOaZsjCvGSHFCuC3drUwN3YAc5_medium.webp","\/storage\/images\/resized\/4QWA67eqfcfyOiA8Wk7YnqroHFqQbTsmDJUYTCTg_medium.webp","\/storage\/images\/resized\/4QWA67eqfcfyOiA8Wk7YnqroHFqQbTsmDJUYTCTg_medium.webp","\/storage\/images\/resized\/GDnYOu1UpMMfMMRV6Aqle4H0YLLsraeD9IP9qScG_medium.webp","\/storage\/images\/resized\/VPE7q24PXoHr5SS2SqfEgxccSMUxWLfZINOX60uo_medium.webp","\/storage\/images\/resized\/VPE7q24PXoHr5SS2SqfEgxccSMUxWLfZINOX60uo_medium.webp","\/storage\/images\/resized\/voXLqlsvTwv5p3iMQ8Dhs95nqB4AXOG7Taj7G4ra_medium.webp","\/storage\/images\/resized\/GDnYOu1UpMMfMMRV6Aqle4H0YLLsraeD9IP9qScG_medium.webp","\/storage\/images\/resized\/MjH1ITP7lMYGxeqUZfkt2BnVLgjkk413jwBV97XX_medium.webp"],"datasets":[{"label":"","data":[2,1,1,1,1,1,1,1,1,1],"backgroundColor":["#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6"],"percentage":[16.67,8.33,8.33,8.33,8.33,8.33,8.33,8.33,8.33,8.33],"barThickness":13}]},"options":{"indexAxis":"y","maintainAspectRatio":false,"scales":{"y":{"ticks":{"precision":0,"autoSkip":false,"font":{"family":"Montserrat"},"color":"#000000"}},"x":{"ticks":{"stepSize":null,"precision":0,"font":{"family":"Montserrat"},"color":"#000000"}}},"plugins":{"legend":{"position":"top","labels":{"font":{"family":"Montserrat"},"color":"#000000"}},"title":{"display":true,"text":"Journals","font":{"size":24,"family":"Montserrat","weight":600},"color":"#000000"}}}},"publishers":{"type":"bar","data":{"show":true,"labels":["Springer Nature","Frontiers Media S.A.","Elsevier","American Society for Microbiology","Taylor & Francis","Multidisciplinary Digital Publishing Institute (MDPI)"],"ids":[8,208,17,142,18,202],"codes":[0,0,0,0,0,0],"imageUrls":["\/storage\/images\/resized\/voXLqlsvTwv5p3iMQ8Dhs95nqB4AXOG7Taj7G4ra_medium.webp","\/storage\/images\/resized\/4QWA67eqfcfyOiA8Wk7YnqroHFqQbTsmDJUYTCTg_medium.webp","\/storage\/images\/resized\/GDnYOu1UpMMfMMRV6Aqle4H0YLLsraeD9IP9qScG_medium.webp","\/storage\/images\/resized\/VPE7q24PXoHr5SS2SqfEgxccSMUxWLfZINOX60uo_medium.webp","\/storage\/images\/resized\/5YZtvLvkPZuc2JHOaZsjCvGSHFCuC3drUwN3YAc5_medium.webp","\/storage\/images\/resized\/MjH1ITP7lMYGxeqUZfkt2BnVLgjkk413jwBV97XX_medium.webp"],"datasets":[{"label":"","data":[3,2,2,2,1,1],"backgroundColor":["#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6"],"percentage":[25,16.67,16.67,16.67,8.33,8.33],"barThickness":13}]},"options":{"indexAxis":"y","maintainAspectRatio":false,"scales":{"y":{"ticks":{"precision":0,"autoSkip":false,"font":{"family":"Montserrat"},"color":"#000000"}},"x":{"ticks":{"stepSize":null,"precision":0,"font":{"family":"Montserrat"},"color":"#000000"}}},"plugins":{"legend":{"position":"top","labels":{"font":{"family":"Montserrat"},"color":"#000000"}},"title":{"display":true,"text":"Publishers","font":{"size":24,"family":"Montserrat","weight":600},"color":"#000000"}}}}}
Metrics
Cite this
GOST |
RIS |
BibTex
Cite this
GOST
Copy
Pobeguts O. V. et al. Propionate Induces Virulent Properties of Crohn’s Disease-Associated Escherichia coli // Frontiers in Microbiology. 2020. Vol. 11.
GOST all authors (up to 50)
Copy
Pobeguts O. V., Ladygina V. G., Evsyutina D. V., Eremeev A. V., Zubov A. I., Matyushkina D. S., Scherbakov P. L., Rakitina D. V., Fisunov G. Y. Propionate Induces Virulent Properties of Crohn’s Disease-Associated Escherichia coli // Frontiers in Microbiology. 2020. Vol. 11.
Cite this
RIS
Copy
TY - JOUR
DO - 10.3389/fmicb.2020.01460
UR - https://doi.org/10.3389%2Ffmicb.2020.01460
TI - Propionate Induces Virulent Properties of Crohn’s Disease-Associated Escherichia coli
T2 - Frontiers in Microbiology
AU - Pobeguts, Olga V
AU - Ladygina, Valentina G.
AU - Evsyutina, Daria V
AU - Eremeev, Artem V
AU - Zubov, Aleksandr I
AU - Matyushkina, Daria S
AU - Scherbakov, Peter L
AU - Rakitina, Daria V
AU - Fisunov, Gleb Y
PY - 2020
DA - 2020/07/08 00:00:00
PB - Frontiers Media S.A.
VL - 11
SN - 1664-302X
ER -
Cite this
BibTex
Copy
@article{2020_Pobeguts,
author = {Olga V Pobeguts and Valentina G. Ladygina and Daria V Evsyutina and Artem V Eremeev and Aleksandr I Zubov and Daria S Matyushkina and Peter L Scherbakov and Daria V Rakitina and Gleb Y Fisunov},
title = {Propionate Induces Virulent Properties of Crohn’s Disease-Associated Escherichia coli},
journal = {Frontiers in Microbiology},
year = {2020},
volume = {11},
publisher = {Frontiers Media S.A.},
month = {jul},
url = {https://doi.org/10.3389%2Ffmicb.2020.01460},
doi = {10.3389/fmicb.2020.01460}
}